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ChemicalBook >> CAS DataBase List >>15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Structure
15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER structure
CAS No.
130273-87-9
Chemical Name:
15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
Synonyms
17-phenyl trinor PGF2α-iPr;JGZRPRSJSQLFBO-DYZSFVSISA-N;15(R)-Bimatoprost isopropyl ester;15-epi Bimatoprost isopropyl ester;17-phenyl trinor PGF2α isopropyl ester;Bimatoprost Acid 15-Epi Isopropyl Ester;15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester;15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;BIMATOPROST ISOPROPYL ESTER/7-[(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3R)-3-HYDROXY-5-PHENYL-1-PENTEN-1-;9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
CBNumber:
CB3350896
Molecular Formula:
C26H38O5
Molecular Weight:
430.58
MDL Number:
MFCD05863953
MOL File:
130273-87-9.mol
Last updated:2025-04-17 18:22:24
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15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Properties

storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);69.67(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);69.67(Max Conc. mM)
PBS (pH 7.2):1.0(Max Conc. mg/mL);2.32(Max Conc. mM)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H360-H336
Precautionary statements  P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16825 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester ≥98% 130273-87-9 1mg $73 2024-03-01 Buy
Cayman Chemical 16825 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester ≥98% 130273-87-9 5mg $324 2024-03-01 Buy
Cayman Chemical 16825 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester ≥98% 130273-87-9 10mg $575 2024-03-01 Buy
Cayman Chemical 16825 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester ≥98% 130273-87-9 50mg $2505 2024-03-01 Buy
AK Scientific 1210AH 15(R)-17-PhenyltrinorprostaglandinF2alphaisopropylester 130273-87-9 50mg $2887 2021-12-16 Buy
Product number Packaging Price Buy
16825 1mg $73 Buy
16825 5mg $324 Buy
16825 10mg $575 Buy
16825 50mg $2505 Buy
1210AH 50mg $2887 Buy

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Chemical Properties,Uses,Production

Description

15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

Uses

15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

References

[1] Resul, et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J. Med. Chem. 36(2), 243-248 (1993).

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1990 58
Shanghai Fuyi Biological Technology Co., Ltd. 18096642264 sales@foreversyn.com China 492 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 13675144456 sean.lv@synzest.com China 11438 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
sgtlifesciences pvt ltd 		58
TargetMol Chemicals Inc. 		58
Shanghai Hongye Biotechnology Co. Ltd 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
Shanghai Fuyi Biological Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bimatoprost isopropyl ester pictures 2024-10-28 Bimatoprost isopropyl ester
130273-87-9
 US $183.00-1430.00 / mg 10g TargetMol Chemicals Inc.

130273-87-9(15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER)Related Search:

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-Bimatoprost isopropyl ester JGZRPRSJSQLFBO-DYZSFVSISA-N 15-epi Bimatoprost isopropyl ester 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER BIMATOPROST ISOPROPYL ESTER/7-[(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3R)-3-HYDROXY-5-PHENYL-1-PENTEN-1- Bimatoprost Isopropyl Ester/7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-Hydroxy-5-Phenyl-1-Penten-1-Yl]Cyclopentyl]-(5Z)-5-Heptenoic Acid 1-Methylethyl Ester Bimatoprost Acid 15-Epi Isopropyl Ester 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)- Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate 17-phenyl trinor PGF2α isopropyl ester 17-phenyl trinor PGF2α-iPr Propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(E,3R)-3-hydroxy-5-phenylpent-1- enyl]cyclopentyl]hept-5-enoate 130273-87-9