LPEPZBJOKDYZAD-ZEJCXXMWSA-N
- CAS No.
- 1185071-99-1
- Chemical Name:
- LPEPZBJOKDYZAD-ZEJCXXMWSA-N
- Synonyms
- LPEPZBJOKDYZAD-ZEJCXXMWSA-N
- CBNumber:
- CB33574989
- Molecular Formula:
- C14H6D4F3NO2
- Molecular Weight:
- 285.254556712
- MDL Number:
- MOL File:
- 1185071-99-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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| Signal word | Warning | |||||||||
| NFPA 704 |
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LPEPZBJOKDYZAD-ZEJCXXMWSA-N price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33272 | Flufenamic Acid-d4 ≥99%deuteratedforms(d1-d4) | 1185071-99-1 | 500μg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 33272 | Flufenamic Acid-d4 ≥99%deuteratedforms(d1-d4) | 1185071-99-1 | 1mg | $329 | 2026-04-30 | Buy |
| Biosynth | KXB07199 | Flufenamic acid-d4 | 1185071-99-1 | 5mg | $1431.15 | 2026-06-04 | Buy |
| Biosynth | KXB07199 | Flufenamic acid-d4 | 1185071-99-1 | 10mg | $1991.1 | 2026-06-04 | Buy |
| Biosynth | KXB07199 | Flufenamic acid-d4 | 1185071-99-1 | 25mg | $3733.5 | 2026-06-04 | Buy |
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Chemical Properties, Uses, Production
Uses
Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
Biological Activity
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 μM for human COX-1 and COX-2, respectively).1 Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner.2 It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 μM, respectively.3 Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1).4 It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.5
References
1.Warner, T.D., Giuliano, F., Vojnovic, I., et al.Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysisProc. Nat. Acad. Sci. USA96(13)7563-7568(1999) 2.Paik, J.H., Ju, J.H., Lee, J.Y., et al.Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathwaysJ. Biol. Chem.275(36)28173-28179(2000) 3.Kankaanranta, H., and Moilanen, E.Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytesMol. Pharmacol.47(5)1006-1013(1995) 4.Guinamard, R., Simard, C., and Del Negro, C.Flufenamic acid as an ion channel modulatorPharmacol. Ther.138(2)272-284(2013) 5.Pongkorpsakol, P., Satitsri, S., Wongkrasant, P., et al.Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activationEur. J. Pharmacol.79894-104(2017)
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016; 18162595016 | 3287908757@qq.com | China | 9111 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8301 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 17717235263 | offer.de@lgcgroup.com | China | 38135 | 58 |
