YEZNLOUZAIOMLT-IKMBEDGYSA-N
- CAS No.
- 1246820-82-5
- Chemical Name:
- YEZNLOUZAIOMLT-IKMBEDGYSA-N
- Synonyms
- D4-Tolfenamic Acid;[2H4]-Tolfenamic Acid;YEZNLOUZAIOMLT-IKMBEDGYSA-N;Tolfenamic-d4 Acid (benzoic-3,4,5,6-d4)
- CBNumber:
- CB33393076
- Molecular Formula:
- C14H8D4ClNO2
- Molecular Weight:
- 265.728227112
- MDL Number:
- MOL File:
- 1246820-82-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
| NFPA 704 |
|
YEZNLOUZAIOMLT-IKMBEDGYSA-N price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28700 | Tolfenamic Acid-d4 ≥99%deuteratedforms(d1-d4) | 1246820-82-5 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 28700 | Tolfenamic Acid-d4 ≥99%deuteratedforms(d1-d4) | 1246820-82-5 | 5mg | $213 | 2026-04-30 | Buy |
| ChemScene | CS-0169723 | Tolfenamic acid-d4 | 1246820-82-5 | 1mg | $184 | 2026-06-04 | Buy |
| ChemScene | CS-0169723 | Tolfenamic acid-d4 | 1246820-82-5 | 5mg | $460 | 2026-06-04 | Buy |
| TRC | T535302 | TolfenamicAcid-d4 | 1246820-82-5 | 5mg | $150 | 2021-12-16 | Buy |
YEZNLOUZAIOMLT-IKMBEDGYSA-N Chemical Properties, Uses, Production
Description
Tolfenamic acid-d4 is intended for use as an internal standard for the quantification of tolfenamic acid by GC- or LC-MS. Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity. It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively). Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; ) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner. It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner. Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells. It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.
Uses
Labelled Tolfenamic Acid. Non-steroidal anti-inflammatory drugs (NSAIDs). A derivative of anthranilic acid, related structurally to Mefenamic and Flufenamic acids. Anti-inflammatory, analgesic.
References
[1] P KAY-MUGFORD. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs.[J]. American journal of veterinary research, 2000, 61 7: 802-810. DOI: 10.2460/ajvr.2000.61.802
[2] H KANKAANRANTA E M. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes.[J]. Molecular Pharmacology, 1995, 47 5: 1006-1013.
[3] D. GALANAKIS. Synthesis and Pharmacological Evaluation of Amide Conjugates of NSAIDs with L‐Cysteine Ethyl Ester, Combining Potent Antiinflammatory and Antioxidant Properties with Significantly Reduced Gastrointestinal Toxicity.[J]. ChemInform, 2004, 16 1 1. DOI: 10.1002/chin.200447168
[4] MAEN ABDELRAHIM. Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.[J]. JNCI Journal of the National Cancer Institute, 2006, 98 12: 855-868. DOI: 10.1093/jnci/djj232
[5] HYEONG-JIN KIM. Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors.[J]. Journal of Clinical Biochemistry and Nutrition, 2013, 53 1: 21-26. DOI: 10.3164/jcbn.12-78
YEZNLOUZAIOMLT-IKMBEDGYSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
YEZNLOUZAIOMLT-IKMBEDGYSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4979 | 58 |
| Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5178 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
