1-Methanesulfonyl-piperazine
- CAS No.
- 55276-43-2
- Chemical Name:
- 1-Methanesulfonyl-piperazine
- Synonyms
- 1-(METHYLSULFONYL)PIPERAZINE;AKOS B003961;1-mesylpiperazine;TIMTEC-BB SBB007001;ART-CHEM-BB B003961;ART-CHEM-BB B022241;IFLAB-BB F2124-0764;CHEMBRDG-BB 3003961;1-METHYLSULPHONYLPIPERAZINE;1-Methanesulfonyl-piperzaine
- CBNumber:
- CB3368178
- Molecular Formula:
- C5H12N2O2S
- Molecular Weight:
- 164.23
- MDL Number:
- MFCD02153225
- MOL File:
- 55276-43-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 99 °C |
|---|---|
| Boiling point | 280.6±50.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 7.78±0.10(Predicted) |
| form | Solid |
| color | White to Almost white |
| Water Solubility | Slightly soluble in water. |
| CAS DataBase Reference | 55276-43-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-24/25-23 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-Methanesulfonyl-piperazine price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2437 | 1-(Methylsulfonyl)piperazine >98.0%(GC) | 55276-43-2 | 5g | $71 | 2026-04-30 | Buy |
| Usbiological | 283742 | 1-(Methylsulfonyl)piperazine Asreported | 55276-43-2 | 5g | $333 | 2026-06-03 | Buy |
| Usbiological | 283742 | 1-(Methylsulfonyl)piperazine Asreported | 55276-43-2 | 10g | $453 | 2026-06-03 | Buy |
| Usbiological | 283742 | 1-(Methylsulfonyl)piperazine Asreported | 55276-43-2 | 25g | $638 | 2026-06-03 | Buy |
| Usbiological | 283742 | 1-(Methylsulfonyl)piperazine Asreported | 55276-43-2 | 50g | $857 | 2026-06-03 | Buy |
1-Methanesulfonyl-piperazine Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
1-(Methylsulfonyl)piperazine is employed as a intermediate for pharmaceutical and chemical research.
Synthesis
164331-38-8
55276-43-2
Step 2: Synthesis of 1-(methylsulfonyl)piperazine A mixture of tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate (1.0 g, 3.79 mmol) with trifluoroacetic acid (TFA, 0.86 g, 7.58 mmol) in dichloromethane (CH2Cl2, 10 mL) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to afford 1-(methylsulfonyl)piperazine as a yellow oil (0.5 g, 80.52% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.50-3.47 (m, 4H), 3.33-3.28 (m, 4H), 2.92 (s, 3H); ESI-MS m/z: 165 ([M + H]+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 375 - 379
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 23
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 152
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2004/85425, 2004, A1. Location in patent: Page 98
1-Methanesulfonyl-piperazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Pleikon Chemical Technology Co., Ltd | 021-54321516 17717324060 | 2719672468@qq.com | China | 2228 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Lastest Price from 1-Methanesulfonyl-piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 1-METHANESULFONYL-PIPERAZINE
55276-43-2
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2021-11-06 | 1-METHANESULFONYL-PIPERAZINE
55276-43-2
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2021-11-05 | 1-METHANESULFONYL-PIPERAZINE
55276-43-2
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 1-METHANESULFONYL-PIPERAZINE
55276-43-2
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-METHANESULFONYL-PIPERAZINE
55276-43-2
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 1-METHANESULFONYL-PIPERAZINE
55276-43-2
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
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