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1-METHANESULFONYL-PIPERAZINE

1-METHANESULFONYL-PIPERAZINE Structure
1-METHANESULFONYL-PIPERAZINE structure
CAS No.
55276-43-2
Chemical Name:
1-METHANESULFONYL-PIPERAZINE
Synonyms
AKOS B003961;1-mesylpiperazine;CHEMBRDG-BB 3003961;ART-CHEM-BB B003961;ART-CHEM-BB B022241;IFLAB-BB F2124-0764;TIMTEC-BB SBB007001;1-METHYLSULPHONYLPIPERAZINE;1-METHANESULFONYL-PIPERAZINE;1-(METHYLSULFONYL)PIPERAZINE
CBNumber:
CB3368178
Molecular Formula:
C5H12N2O2S
Molecular Weight:
164.23
MDL Number:
MFCD02153225
MOL File:
55276-43-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:12
Product description Number Pack Size Price
1-(Methylsulfonyl)piperazine >98.0%(GC) M2437 5g $71
1-METHANESULFONYL-PIPERAZINE 98% 58323 5G $45
1-METHANESULFONYL-PIPERAZINE 98% 58323 25G $120
1-METHANESULFONYL-PIPERAZINE 98% 58323 4*25G $429
1-(Methylsulfonyl)Piperazine Hydrochloride ≥95%(NMR) 23455 1G $51.18
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1-METHANESULFONYL-PIPERAZINE Properties

Melting point 99 °C
Boiling point 280.6±50.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 7.78±0.10(Predicted)
form Solid
color White to Almost white
Water Solubility Slightly soluble in water.
CAS DataBase Reference 55276-43-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36/37/39-24/25-23
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
2 0

1-METHANESULFONYL-PIPERAZINE price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M2437 1-(Methylsulfonyl)piperazine >98.0%(GC) 55276-43-2 5g $71 2026-04-30 Buy
AstaTech 58323 1-METHANESULFONYL-PIPERAZINE 98% 55276-43-2 5G $45 2026-04-30 Buy
AstaTech 58323 1-METHANESULFONYL-PIPERAZINE 98% 55276-43-2 25G $120 2026-04-30 Buy
AstaTech 58323 1-METHANESULFONYL-PIPERAZINE 98% 55276-43-2 4*25G $429 2026-04-30 Buy
Chem-Impex 23455 1-(Methylsulfonyl)Piperazine Hydrochloride ≥95%(NMR) 55276-43-2 1G $51.18 2026-05-19 Buy
Product number Packaging Price Buy
M2437 5g $71 Buy
58323 5G $45 Buy
58323 25G $120 Buy
58323 4*25G $429 Buy
23455 1G $51.18 Buy

1-METHANESULFONYL-PIPERAZINE Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

1-(Methylsulfonyl)piperazine is employed as a intermediate for pharmaceutical and chemical research.

Synthesis

TERT-BUTYL 4-(METHYLSULFONYL)PIPERAZINE-1-CARBOXYLATE

164331-38-8

1-METHANESULFONYL-PIPERAZINE

55276-43-2

Step 2: Synthesis of 1-(methylsulfonyl)piperazine A mixture of tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate (1.0 g, 3.79 mmol) with trifluoroacetic acid (TFA, 0.86 g, 7.58 mmol) in dichloromethane (CH2Cl2, 10 mL) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to afford 1-(methylsulfonyl)piperazine as a yellow oil (0.5 g, 80.52% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.50-3.47 (m, 4H), 3.33-3.28 (m, 4H), 2.92 (s, 3H); ESI-MS m/z: 165 ([M + H]+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 375 - 379
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 23
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 152
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2004/85425, 2004, A1. Location in patent: Page 98

1-METHANESULFONYL-PIPERAZINE Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Trifluoroacetic acid Triethylamine Chloroform Piperazine
Ethyl chloroformate Methanesulfonyl chloride Isopropyl acetate Diethyl ether Ethyl acetate
Dichloromethane Methanol Sodium hydroxide Isopropyl alcohol Sodium carbonate

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Preparation Products

1-Piperazinecarbonyl chloride, 4-(methylsulfonyl)-

1-METHANESULFONYL-PIPERAZINE Suppliers

Global( 194)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3996 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 1-METHANESULFONYL-PIPERAZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-METHANESULFONYL-PIPERAZINE pictures 2025-12-24 1-METHANESULFONYL-PIPERAZINE
55276-43-2
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
1-METHANESULFONYL-PIPERAZINE pictures 2021-11-06 1-METHANESULFONYL-PIPERAZINE
55276-43-2
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
1-METHANESULFONYL-PIPERAZINE pictures 2021-11-05 1-METHANESULFONYL-PIPERAZINE
55276-43-2
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd

1-METHANESULFONYL-PIPERAZINE Spectrum

1-METHANESULFONYL-PIPERAZINE(55276-43-2)1HNMR

55276-43-2(1-METHANESULFONYL-PIPERAZINE)Related Search:

1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE H-7 DIHYDROCHLORIDE 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE 1-(8-CHLORO-5-ISOQUINOLINE-SULFONYL)PIPERAZINE 1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE DIHYDROCHLORIDE
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7-(4-[(4-CHLOROPHENYL)SULFONYL]PIPERAZINO)-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 2-NITRO-1-((4-(5-(TRIFLUOROMETHYL)(2-PYRIDYL))PIPERAZINYL)SULFONYL)BENZENE 1-((4-(3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYL))PIPERAZINYL)SULFONYL)-2-NITROBENZENE ETHYL 2-(1-[(4-CHLOROPHENYL)SULFONYL]-3-OXO-2-PIPERAZINYL)ACETATE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE
N,1-DIMETHYL-6-[4-(METHYLSULFONYL)PIPERAZINO]-3,5-DINITRO-1,4-DIHYDRO-2-PYRIDINAMINE N,N'-BIS(BENZENESULFONYL)PIPERAZINE N,N'-BIS(O-TOLUENESULFONYL)PIPERAZINE

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1-METHANESULFONYL-PIPERAZINE 1-N-METHANESULFONYLPIPERAZINE 1-(METHYLSULFONYL)PIPERAZINE 1-METHYLSULPHONYLPIPERAZINE AKOS B003961 CHEMBRDG-BB 3003961 1-METHANESULFONYL-PIPERAZINE >98% 1-(Methylsulphonyl)piperazine 98+% IFLAB-BB F2124-0764 ART-CHEM-BB B022241 ART-CHEM-BB B003961 TIMTEC-BB SBB007001 1-(methylsulfonyl)piperazine(SALTDATA: FREE) Methyl (piperazin-1-yl) sulphone Piperazine, 1-(methylsulfonyl)- 1-mesylpiperazine 1-(Methylsulfonyl)piperazine> 1-(Methylsulfonyl)piperazine,97% 1-Methanesulfonyl-piperzaine 1-Methanesulfonyl piperizine 55276-43-2 C5H12N2O2SHCl piperazines Amines and Anilines Heterocycles Buildingblock