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| | 1-METHANESULFONYL-PIPERAZINE Basic information |
| | 1-METHANESULFONYL-PIPERAZINE Chemical Properties |
| Melting point | 99 °C | | Boiling point | 280.6±50.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 7.78±0.10(Predicted) | | form | Solid | | color | White to Almost white | | Water Solubility | Slightly soluble in water. | | CAS DataBase Reference | 55276-43-2(CAS DataBase Reference) |
| | 1-METHANESULFONYL-PIPERAZINE Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 1-(Methylsulfonyl)piperazine is employed as a intermediate for pharmaceutical and chemical research. | | Synthesis | Step 2: Synthesis of 1-(methylsulfonyl)piperazine
A mixture of tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate (1.0 g, 3.79 mmol) with trifluoroacetic acid (TFA, 0.86 g, 7.58 mmol) in dichloromethane (CH2Cl2, 10 mL) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to afford 1-(methylsulfonyl)piperazine as a yellow oil (0.5 g, 80.52% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.50-3.47 (m, 4H), 3.33-3.28 (m, 4H), 2.92 (s, 3H); ESI-MS m/z: 165 ([M + H]+). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 375 - 379
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 23
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 152
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2004/85425, 2004, A1. Location in patent: Page 98 |
| | 1-METHANESULFONYL-PIPERAZINE Preparation Products And Raw materials |
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