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D-AP5

D-AP5 structure

CAS No.: 79055-68-8

Chemical Name:: D-AP5

Synonyms: EIF4G2;D-AP5;IF4G2;D-APV;(R)-AP-5;Emasol L10;Emasol L 10;Emasol L-10;D-AP5(mM/ml);D-AP5 ，E1246

CBNumber:: CB3371309

Molecular Formula:: C5H12NO5P

Molecular Weight:: 197.13

MDL Number:: MFCD00078839

MOL File:: 79055-68-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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D-AP5 Properties

Melting point	approximate 233℃
Boiling point	482.1±55.0 °C(Predicted)
Density	1.529±0.06 g/cm3(Predicted)
RTECS	RD2513000
storage temp.	Store at RT
solubility	Soluble to 100 mM in sterile
form	White solid
pka	2.46±0.10(Predicted)
color	White
Water Solubility	Soluble in water (100mM)
Sensitive	Light Sensitive
InChI	1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
InChIKey	VOROEQBFPPIACJ-SCSAIBSYSA-N
SMILES	N[C@H](CCCP(O)(O)=O)C(O)=O
FDA UNII	CD39X2NL7F
UNSPSC Code	12352106
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

D-AP5 price More Price(80)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A8054	D(?)-2-Amino-5-phosphonopentanoic acid NMDA receptor antagonist	79055-68-8	1mg	$99.2	2026-04-30	Buy
Sigma-Aldrich	165304	D-(–)-2-Amino-5-phosphonopentanoic Acid	79055-68-8	5mg	$193	2026-04-30	Buy
Cayman Chemical	14539	D-AP5 ≥95%	79055-68-8	5mg	$83	2026-04-30	Buy
Cayman Chemical	14539	D-AP5 ≥95%	79055-68-8	10mg	$141	2026-04-30	Buy
Cayman Chemical	14539	D-AP5 ≥95%	79055-68-8	50mg	$578	2026-04-30	Buy

Product number	Packaging	Price	Buy
A8054	1mg	$99.2	Buy
165304	5mg	$193	Buy
14539	5mg	$83	Buy
14539	10mg	$141	Buy
14539	50mg	$578	Buy

D-AP5 Chemical Properties, Uses, Production

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (K_d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

References

[1] MORRIS R G. Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5.[J]. Journal of Neuroscience, 1989, 9 9: 3040-3057.

D-AP5 Preparation Products And Raw materials

Raw materials

Preparation Products

D-AP5 Suppliers

Global Suppliers ( 182)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai ChuangYan Chemical Technology Co., Ltd.	021-11111111 11111111111	546919421@qq.com	China	3789	55
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Ascent Scientific	60
Syntechem Co.,Ltd	57
Dalian Meilun Biotech Co., Ltd.	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Guangzhou Isun Pharmaceutical Co., Ltd	55
TargetMol Chemicals Inc.	58
Bide Pharmatech Ltd.	60
Shanghai ChuangYan Chemical Technology Co., Ltd.	55
Shanghai Macklin Biochemical Co.,Ltd.	55

View Latest Price from D-AP5 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	D-AP5 79055-68-8	$30.00-64.00		99.94%	10g	TargetMol Chemicals Inc.
	2026-07-27	D-AP5 79055-68-8	$30.00-64.00		99.94%	10g	TargetMol Chemicals Inc.

D-AP5
79055-68-8
$30.00-64.00
99.94%
TargetMol Chemicals Inc.

D-AP5
79055-68-8
$30.00-64.00
99.94%
TargetMol Chemicals Inc.

D-AP5 Spectrum

D-AP5(79055-68-8)¹HNMR

79055-68-8 (D-AP5) Related Search:

12AP ANTI-IGM MU-CHAIN, RAT AP CONJ ANTI-IGG H AND L CHAIN, GOAT AP CONJ ANTI-IMMUNOGLOBULIN A, HUMAN, AP D-AP5

ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ ANTI-IGG, HUMAN AP CONJ ANTI-IGG, MOUSE AP CONJ ANTI-IGG(H+L), HUMAN AP CONJ,ANTI-IGG H AND L CHAIN, HUMAN AP CONJ ANTI-IGG(H+L), RABBIT AP CONJ,ANTI-IGG H AND L CHAIN, RABBIT AP CONJ

ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP ANTI-IGG H AND L CHAIN, HORSE AP CONJ 16-(9-Anthroyloxy)palmitic acid DL-2-Amino-5-phosphonopentanoic acid 5-Phosphonopentanoic acid

4-Aminobutylphosphonic acid ANTI-IMMUNOGLOBULIN G, CAT, F(AB')2, AP ANTI-IGM MU-CHAIN, HUMAN AP CONJ

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D-AP5 D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID D(-)-2-Amino-5-phosphonovaleric acid hydrate D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5) D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid (R)-2-aMino-5-phosphonopentanoic acid (2R)-2-aMMonio-5-phosphonatopentanoate Anti-EIF4G2, N-Terminal antibody produced in rabbit Death associated protein 5 EIF4G2 Eukaryotic translation initiation factor 4 γ 2 IF4G2 D(-)-2-Amino-5-phosphonovaleric acid (D-AP5) (2R)-2-Amino-5-phosphonovaleric acid (R)-2-Amino-5-phosphonovaleric acid (R)-5-Phosphono-2-aminovaleric acid (R)-AP-5 D-APV D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee) D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC 5-Phosphono-D-norvaline D(-)-2-AMINO-5-PHOSPHONOVALERIC ACID (D-AP5);5-PHOSPHONO-D-NORVALINE D-Norvaline, 5-phosphono- Emasol L 10 Emasol L10 Emasol L-10 (-)-2-Amino-5-phosphonovaleric acid D-APV|||D-2-Amino-5-phosphonovaleric acid D-AP5(mM/ml) D-AP5, NMDA glutamate site antagonist D-AP5 (mM/ml), NMDA glutamate site antagonist D-AP5, 10 mM in DMSO D(?)-2-Amino-5-phosphonopentanoic acid D-AP5 ，E1246 D-AP5 (Synonyms: D-APV 79055-68-8 C5H12NO5P Glutamate Glutamate receptor