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ChemicalBook >> CAS DataBase List >>2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide Structure
2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide structure
CAS No.
206549-55-5
Chemical Name:
2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide
Synonyms
MMP9 Inhibitor I,MMP 9 Inhibitor I;MMP-9 Inhibitor I (Matrix Metalloproteinase-9 Inhibitor I);2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide;Benzamide, 5-[(diethylamino)methyl]-N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-3-methyl-
CBNumber:
CB33777418
Molecular Formula:
C27H33N3O5S
Molecular Weight:
511.63
MDL Number:
MOL File:
206549-55-5.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide Properties

Density 1.250±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/ml
form A solid
pka 8.23±0.42(Predicted)
color White to off-white

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15942 MMP-9 Inhibitor I ≥95% 206549-55-5 500μg $160 2026-04-30 Buy
ChemScene CS-0064904 MMP-9-IN-9 99.26% 206549-55-5 500??g $157 2026-06-04 Buy
ChemScene CS-0064904 MMP-9-IN-9 99.26% 206549-55-5 1mg $251 2026-06-04 Buy
ChemScene CS-0064904 MMP-9-IN-9 99.26% 206549-55-5 5mg $628 2026-06-04 Buy
ChemScene CS-0064904 MMP-9-IN-9 99.26% 206549-55-5 10mg $1005 2026-06-04 Buy
Product number Packaging Price Buy
15942 500μg $160 Buy
CS-0064904 500??g $157 Buy
CS-0064904 1mg $251 Buy
CS-0064904 5mg $628 Buy
CS-0064904 10mg $1005 Buy

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide Chemical Properties, Uses, Production

Description

MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).1 It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM).2 MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

Uses

MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects[1].

Definition

ChEBI: MMP9 inhibitor I is a hydroxamic acid that is N-hydroxy-3-methylbenzamide in which the the hydrogens at positions 2 and 5 have been replaced by benzyl[(4-methoxyphenyl)sulfonyl]amino and (diethylamino)methyl groups, respectively. It is a cell-permeable, potent, selective, and reversible inhibitor of matrix metallopeptidase-9 (MMP-9, EC 3.4.24.35). It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor. It is a hydroxamic acid, a tertiary amino compound, a sulfonamide and an aromatic ether.

IC 50

MMP-9: 5 nM (IC50); MMP-1: 1050 nM (IC50); MMP-13: 113 nM (IC50)

References

1. Levin, J.I., Chen, J., Du, M., et al. The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P11 groups Bioorg. Med. Chem. Lett. 11(16),2189-2192(2001).
2. Lee, E.-J., Moon, P.-G., Baek, M.-C., et al. Comparison of the effects of matrix metalloproteinase inhibitors on TNF-α release from activated microglia and TNF-α converting enzyme activity Biomol. Ther. (Seoul) 22(5),414-419(2014).

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide Suppliers

Global Suppliers ( 11)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29676 58
Chengdu Peter-like Biotechnology Co., Ltd. 028-81700200 13308200041 2851167782@qq.com China 10763 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58

View Latest Price from 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MMP-9 Inhibitor I pictures 2026-07-27 MMP-9 Inhibitor I
206549-55-5
 $118.00 10g TargetMol Chemicals Inc.

206549-55-5 (2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide) Related Search:

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2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide MMP9 Inhibitor I,MMP 9 Inhibitor I Benzamide, 5-[(diethylamino)methyl]-N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-3-methyl- MMP-9 Inhibitor I (Matrix Metalloproteinase-9 Inhibitor I) 206549-55-5