MMP-8 INHIBITOR I
- CAS No.
- 236403-25-1
- Chemical Name:
- MMP-8 INHIBITOR I
- Synonyms
- MMP 8-I;MMP-8 INHIBITOR I;MMP-8 Inhibitor I (Matrix Metalloproteinase-8 Inhibitor I);(3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE];3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-
- CBNumber:
- CB4710190
- Molecular Formula:
- C17H18N2O5S
- Molecular Weight:
- 362.4
- MDL Number:
- MFCD02683950
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Light Yellow |
| InChI | InChI=1S/C17H18N2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m1/s1 |
| InChIKey | PPELJLBDXLMTEW-MRXNPFEDSA-N |
| SMILES | C1C2=C(C=CC=C2)C[C@H](C(NO)=O)N1S(C1=CC=C(OC)C=C1)(=O)=O |
MMP-8 INHIBITOR I price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21852 | MMP-8 Inhibitor I ≥95% | 236403-25-1 | 1mg | $222 | 2026-04-30 | Buy |
| TRC | TRC-M425440-50MG | MMP 8-I | 236403-25-1 | 50mg | $906 | 2026-06-03 | Buy |
| TRC | TRC-M425440-10MG | MMP 8-I | 236403-25-1 | 10mg | $202 | 2026-06-03 | Buy |
| TRC | TRC-M425440-100MG | MMP 8-I | 236403-25-1 | 100mg | $1489 | 2026-06-03 | Buy |
| ChemScene | CS-0095345 | MMP-8 inhibitor-1 99.70% | 236403-25-1 | 1mg | $141 | 2026-06-04 | Buy |
MMP-8 INHIBITOR I Chemical Properties, Uses, Production
Description
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.
Uses
MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells.
in vivo
MMP-8 inhibitor-1 (compound 21) (100 mg/kg, orally) has not significant oral bioavailability, with maximal plasma levels (Cmax) of only 2.3 mg/mL[1].
IC 50
MMP-8
References
[1] HANS MATTER. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure–activity relationship[J]. Bioorganic & Medicinal Chemistry, 2002, 10 11: Pages 3529-3544. DOI: 10.1016/s0968-0896(02)00215-8
[2] MCNULTY A, WEINBERG B J, GUILAK F. Inhibition of Matrix Metalloproteinases Enhances In Vitro Repair of the Meniscus[C]//38 1. 2009: 0. DOI: 10.1007/s11999-008-0596-6
[3] GERALD W PRAGER. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.[J]. Blood, 2004, 103 3: 955-962. DOI: 10.1182/blood-2003-07-2214
[4] QISHAN CHEN. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.[J]. Mediators of Inflammation, 2013: 928315. DOI: 10.1155/2013/928315
[5] JULIE DECOCK. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.[J]. Breast Cancer Research: BCR, 2015: 38. DOI: 10.1186/s13058-015-0545-8
[6] MUGE SARPER. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.[J]. Breast Cancer Research: BCR, 2017: 33. DOI: 10.1186/s13058-017-0822-9
MMP-8 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19904 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29676 | 58 |
| Shanghai Easy CDMO Co.,Ltd | Info@easycdmo.com 13564957716 | Info@easycdmo.com | China | 9999 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40048 | 58 |
