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ChemicalBook >> CAS DataBase List >>3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Structure
3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride structure
CAS No.
1173023-36-3
Chemical Name:
3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride
Synonyms
L-745,870 HYDROCHLORIDE;L-745870 hydrochloride, 10 mM in DMSO;3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride;3-((4-(4-chlorophenyl)azine-1-yl)methyl)-1H-pyridinebenzo[2,3-b]pyridinehydrochloride;L745870,dopamine,L 745870,inhibit,penetration,receptor,Human,brain,Inhibitor,neuroleptics,L-745870,Dopamine Receptor,L 745870 hydrochloride,L745870 hydrochloride
CBNumber:
CB3387546
Molecular Formula:
C18H20Cl2N4
Molecular Weight:
363.28
MDL Number:
MFCD01529971
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:01
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3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Properties

storage temp. Store at -20°C
solubility H2O: 0.2 mg/mL
form solid
color white
Water Solubility H2O: 0.2mg/mL
ethanol: 1.4mg/mL
0.1 M HCl: 5.5mg/mL
InChI 1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H
InChIKey GFFJYISJZJIKAF-UHFFFAOYSA-N
SMILES Cl.Clc1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
FDA UNII X2UD7T27FU
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L131 L-745,870 hydrochloride 1173023-36-3 5mg $352 2026-04-30 Buy
Sigma-Aldrich L131 L-745,870 hydrochloride 1173023-36-3 25mg $1010 2026-04-30 Buy
Biosynth YWB02336 L-745870 Hydrochloride 1173023-36-3 25mg $801.75 2026-06-05 Buy
Biosynth YWB02336 L-745870 Hydrochloride 1173023-36-3 50mg $1283.5 2026-06-05 Buy
Biosynth YWB02336 L-745870 Hydrochloride 1173023-36-3 100mg $1785 2026-06-05 Buy
Product number Packaging Price Buy
L131 5mg $352 Buy
L131 25mg $1010 Buy
YWB02336 25mg $801.75 Buy
YWB02336 50mg $1283.5 Buy
YWB02336 100mg $1785 Buy

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Chemical Properties, Uses, Production

Uses

L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors[1][2][3].

Biological Activity

Selective D4 dopamine receptor antagonist.

in vivo

L-745870 has good pharmacokinetic properties (20-60% oral bioavailability and plasma t1/2 2.1-2.8 hours) in both rat and monkey, and excellent brain penetration with high brain to plasma ratios in rat[1].
Following oral administration to squirrel monkeys, L745870 (10 mg/kg p.o.) induces mild sedation and extrapyramidal motor symptoms, notably bradykinesia, became apparent at 30 mg/kg. Lower doses of L-745870 has no observable behavioural effects in monkeys[1].

IC 50

Human D4 Receptor: 4.3 nM (Ki); D2 Receptor: 960 nM (Ki); D3 Receptor: 2300 mM (Ki)

References

[1] Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8. DOI:10.1016/s0165-6147(97)01066-3
[2] Patel S, et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47. PMID:9353380
[3] Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2. DOI:10.1021/jm9600712

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9790 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Supplier Advantage
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Zhejiang Huida Biotech Co., LTD 58
cjbscvictory 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58

View Latest Price from 3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-745870 hydrochloride pictures 2026-07-15 L-745870 hydrochloride
1173023-36-3
 $34.00-113.00 99.58% 10g TargetMol Chemicals Inc.
L-745870 hydrochloride pictures 2026-07-15 L-745870 hydrochloride
1173023-36-3
 $34.00-113.00 99.58% 10g TargetMol Chemicals Inc.

3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride Spectrum

3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE(1173023-36-3)1HNMR

1173023-36-3 (3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride) Related Search:

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Bromocriptine mesylate

1of2

L-745,870 HYDROCHLORIDE L745870,dopamine,L 745870,inhibit,penetration,receptor,Human,brain,Inhibitor,neuroleptics,L-745870,Dopamine Receptor,L 745870 hydrochloride,L745870 hydrochloride L-745870 hydrochloride, 10 mM in DMSO 3-((4-(4-chlorophenyl)azine-1-yl)methyl)-1H-pyridinebenzo[2,3-b]pyridinehydrochloride 3-([4-(4-Chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo(2,3-b)pyridine hydrochloride 1173023-36-3 C18H19ClN4HCl