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(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine structure

CAS No.: 67496-29-1

Chemical Name:: (6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine

Synonyms: (6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine;(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine - [B90242]

CBNumber:: CB33890535

Molecular Formula:: C8H8BrNO2

Molecular Weight:: 230.05862

MDL Number:

MOL File:: 67496-29-1.mol

MSDS File:: SDS

Last updated:2026-05-28 06:21:03

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(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine Properties

storage temp.	2-8°C(protect from light)
Appearance	Light yellow to yellow Viscous Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	303893	(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine	67496-29-1	250.00mg	$58	2026-05-19	Buy
Matrix Scientific	303893	(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine	67496-29-1	1.00g	$95	2026-05-19	Buy
Matrix Scientific	303893	(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine	67496-29-1	5.00g	$450	2026-05-19	Buy
Synthonix	B90242	(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine 97%	67496-29-1	100mg	$51	2026-05-06	Buy
Synthonix	B90242	(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine 97%	67496-29-1	250mg	$60	2026-05-06	Buy

Product number	Packaging	Price	Buy
303893	250.00mg	$58	Buy
303893	1.00g	$95	Buy
303893	5.00g	$450	Buy
B90242	100mg	$51	Buy
B90242	250mg	$60	Buy

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine Chemical Properties, Uses, Production

Synthesis

6-BROMO-1,3-BENZODIOXOLE-5-CARBALDEHYDE OXIME

65417-74-5

67496-29-1

General procedure for the synthesis of (6-bromo-benzo[d][1,3]dioxol-5-yl)methanamine from the compound (CAS: 65417-74-5): hydrochloric acid (2 N, 35.3 mL; 70.7 mmol, 10 eq.) was added to a tetrahydrofuran (THF, 80 mL) solution of hydroxylamine (7 mmol, 1 eq.), followed by zinc powder ( 4.62 g, 70.7 mmol, 10 equiv). The reaction mixture was stirred vigorously under reflux conditions until the reaction was complete. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through a pad of diatomaceous earth and concentrated under reduced pressure to remove THF. The aqueous layer was extracted with ethyl acetate (EtOAc, 30 mL), followed by adjusting the pH of the aqueous layer to >10 by addition of saturated aqueous ammonia solution, and then extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, dried with anhydrous potassium carbonate (K2CO3), filtered and the solvent evaporated to give the crude product. The crude product was purified by silica gel fast column chromatography (eluent: ethyl acetate/2% triethylamine) to afford 2-bromo-4,5-dimethoxybenzylamine (7) (1.43 g, 83% yield) as a white powder.1H NMR (300 MHz, CDCl3) δ (ppm): 6.98 (s, 1H), 6.89 (s, 1H), 3.85-3.81 (m, 8H). 8H). 13C NMR (75 MHz, CDCl3) δ (ppm): 148.5, 148.4, 134.2, 115.6, 113.2, 112.0, 56.2, 56.0, 46.6.

References

[1] Synlett, 1999, # 4, p. 501 - 503
[2] Tetrahedron Asymmetry, 2006, vol. 17, # 4, p. 642 - 657
[3] Heterocycles, 2014, vol. 88, # 1, p. 807 - 815
[4] Journal of Organometallic Chemistry, 1985, vol. 281, p. 389 - 396
[5] Organic Letters, 2018, vol. 20, # 2, p. 441 - 444

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine synthesis

Synthesis of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine from 6-Bromo-1,3-benzodioxole-5-carbaldehyde oxime

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine Preparation Products And Raw materials

Raw materials

6-Bromo-1,3-benzodioxole-5-carbaldehyde oxime Water Tetrahydrofuran Hydrochloric acid ZINC

Preparation Products

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine Suppliers

Global Suppliers ( 13)

Supplier	Tel	Email	Country	ProdList	Advantage
LABTER PHARMATECH(BEIJING) CO.,LTD	010-56330744 18310155299	sales@labter.com.cn	China	19999	55
Shanghai Jizhi Biochemical Technology Co. Ltd.	021-4009004166/18616739031 18616739031	3007523370@qq.com	China	40000	58
Henan Alpha Chemical Co., Ltd.	0371-55055611 18137792234	3957071458@qq.com	China	9921	58
Taizhou Nanfeng Pharmaceutical Research Institute	nanfengpharma@126.co 18616377689	nanfengpharma@126.com	China	20008	58
Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	54996	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	690231469@qq.com	China	8000	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
Bide Pharmatech Ltd.	400-6005915	sales@picasso-e.com	China	39645	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 17801761073	Gsiyu@solarbio.com	China	50748	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-025-66113011 15955137747	cb5@aikonchem.com	China	10354	58

Supplier	Advantage
LABTER PHARMATECH(BEIJING) CO.,LTD	55
Shanghai Jizhi Biochemical Technology Co. Ltd.	58
Henan Alpha Chemical Co., Ltd.	58
Taizhou Nanfeng Pharmaceutical Research Institute	58
Shanghai Haohong Pharmaceutical Co., Ltd.	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	58
Bide Pharmatech Ltd.	58
Bide Pharmatech Ltd.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine Spectrum

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine(67496-29-1)¹HNMR

67496-29-1 ((6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine) Related Search:

[(6-bromo-1,3-benzodioxol-5-yl)methyl]amine hydrochloride CHEMBRDG-BB 9071914 N-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)ethanamine 1,3-Benzodioxole-5-methanamine, 4-bromo- (6-Bromo-1,3-benzodioxol-5-yl)methyl]hydrazine hydrochloride

(4-Bromobenzo[d][1,3]dioxol-5-yl)methanamine hydrochloride

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(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine (6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine - [B90242] 67496-29-1