SANGUINARINE
- CAS No.
- 2447-54-3
- Chemical Name:
- SANGUINARINE
- Synonyms
- 13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium;C06162;Sangrovit;sanguirine;SANGUINARIN;SANGUINARINE;Free sanguinarine;Sanguinarine (8CI);PSEUDOCHELERYTHRINE;SANGUINARINE, 40+% BY UV
- CBNumber:
- CB3395590
- Molecular Formula:
- C20H14NO4
- Molecular Weight:
- 332.33
- MDL Number:
- MFCD00064925
- MOL File:
- 2447-54-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Sanguinarine Asreported | 289405 | 5mg | $356 |
| Sanguinarine Asreported | 289405 | 10mg | $492 |
| Sanguinarine Asreported | 289405 | 25mg | $666 |
| Sanguinarine Asreported | 289405 | 50mg | $902 |
| Sanguinarine Asreported | 289405 | 100mg | $1238 |
| More product size | |||
| Melting point | 205-215°C |
|---|---|
| Boiling point | 483.53°C (rough estimate) |
| Density | 1.3463 (rough estimate) |
| refractive index | 1.5180 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| color | White |
| LogP | -0.653 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | AV9VK043SS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Risk Statements | 25 |
| Safety Statements | 13-45 |
| RIDADR | 1544 |
| Toxicity | LD50 oral in rat: 1660mg/kg |
SANGUINARINE price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 289405 | Sanguinarine Asreported | 2447-54-3 | 5mg | $356 | 2026-06-03 | Buy |
| Usbiological | 289405 | Sanguinarine Asreported | 2447-54-3 | 10mg | $492 | 2026-06-03 | Buy |
| Usbiological | 289405 | Sanguinarine Asreported | 2447-54-3 | 25mg | $666 | 2026-06-03 | Buy |
| Usbiological | 289405 | Sanguinarine Asreported | 2447-54-3 | 50mg | $902 | 2026-06-03 | Buy |
| Usbiological | 289405 | Sanguinarine Asreported | 2447-54-3 | 100mg | $1238 | 2026-06-03 | Buy |
SANGUINARINE Chemical Properties,Uses,Production
Description
Sanguinarine, a DNA intercalator extracted from the bloodroot plant of the poppy family, was used by Native Americans for warts and as a blood purifier. In modern use, although banned by the FDA for its association with epidemic dropsy and other toxic effects, it has shown potential as a treatment for cancer, with modes of action including inhibition of metastasis and angiogenesis, and promotion of apoptosis. It also has anti-inflammatory, anti-oxidant, and anti-microbial properties, and several applications in veterinary medicine.
Sources
https://en.wikipedia.org/wiki/Sanguinarine
https://pubchem.ncbi.nlm.nih.gov/compound/sanguinarine#section=Human-Metabolite-Information
https://www.essense-of-life.com/healthtopics/A-513/Sanguinarine-Health-Topic.html
https://www.caymanchem.com/product/16951
https://www.sciencedirect.com/topics/nursing-and-health-professions/sanguinarine
Description
A naphthoisoquinoline alkaloid, this base occurs in the roots of Chelidonium majus L., Glaucium fimbrilligerum and Sanguinaria canadensis L. The alkaloid was stated by Schmidt, Konig and Tietz to crystallize from EtOH or AcOEt as colourless needles, m.p. 213°C but this low melting point was found to be due to the presence of chelerythrine as an impurity. Once this is removed as the pseudocyanide, the base crystallizes from Et20 and has the above melting point or 242-3°C on slow heating. Obtained from EtOH it forms the alcoholate, m.p. 195-7°C. The hydrochloride forms long, slender, bloodred needles. On distillation with Zn dust, the alkaloid furnishes a-naphthaphenanthridine and the structure given above has been further confirmed by synthesis.
Chemical Properties
Soluble in methanol, ethanol solution, insoluble in petroleum ether, chloroform. Derived from the rooted whole herb of Boraginaceae.
Uses
Sanguinarium induces HO-1 expression thus inhibiting MMP-9 and COX-2 expression in TPA-induced breast cancer cells.
Definition
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadendid. Limited available evidence indicates that it may be used to prevent and treat UV-induced skin damage. Specifically, topical application of sanguinarine on the skin of SKH-1 hairless mice before or after UVB irradiation resulted in significantly lower UVB-mediated skin edema, skin hyperplasia and infiltration of leukocytes, and markers of oxidative stress (e.g., H2O2).
References
Dana., Mag. Pharm., 23, 125 (1829)
Bruchhausen, Bersch., Ber., 63, 2520 (1930)
Spath, Kuffner., ibid, 64, 370, 1123, 2034 (1931)
Synthesis:
Dyke, Moon, Sainsbury., Tetrahedron Lett., 3933 (1968)
SANGUINARINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213306 +86-18374838656 | info@staherb.cn | China | 987 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Zhuoer Chemical Co., Ltd | 02120970332; | sales@zhuoerchem.com | China | 2901 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712779 +86-13289823923 | 1090@dideu.com | China | 8651 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
Related articles
- The Duality of Sanguinarine: Anticancer Potential, Carcinogenic Controversy and Clinical Outlook
- Sanguinarine is an alkaloid found in many medicinal plants. It has diverse biological activities, including modulation of nucl....
- Apr 1,2025
View Lastest Price from SANGUINARINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-15 | Sanguinarine
2447-54-3
|
$94.00-258.00 | 98.42% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-12 | Plumepoppy Extract
2447-54-3
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
 |
2023-02-24 | Sanguinarine
2447-54-3
|
20mg | ≥98%(HPLC | 100 g | Shanghai Standard Technology Co., Ltd. |
-
- Sanguinarine
2447-54-3
- $94.00-258.00
- 98.42%
- TargetMol Chemicals Inc.
-
- Plumepoppy Extract
2447-54-3
- $0.00
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Sanguinarine
2447-54-3
- $0.00
- ≥98%(HPLC
- Shanghai Standard Technology Co., Ltd.
