Coptisine chloride
- CAS No.
- 6020-18-4
- Chemical Name:
- Coptisine chloride
- Synonyms
- Q-100696;NSC-119754;Coptisine Hcl;Coptisin chloride;Coptisine choride;COPTISINE CHLORIDE;Coptisin chloride-RM;COPTISINE CHLORIDE(P);Coptisine Hydrochloride;Coptisine chloride (Standard)
- CBNumber:
- CB0718668
- Molecular Formula:
- C19H14ClNO4
- Molecular Weight:
- 355.77
- MDL Number:
- MFCD00016676
- MOL File:
- 6020-18-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >258°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| color | Orange to Dark Orange |
| Stability | Hygroscopic |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChI | InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1 |
| InChIKey | LUXPUVKJHVUJAV-UHFFFAOYSA-M |
| SMILES | C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-] |
| FDA UNII | 4RSB8UY88E |
| UNSPSC Code | 12352205 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H373-H301-H330-H311 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P314-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 2 Oral |
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| NFPA 704 |
|
Coptisine chloride price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00314 | Coptisine Chloride ≥98% (HPLC) | 6020-18-4 | 25MG | $449 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL89524 | Coptisine chloride phyproof? Reference Substance | 6020-18-4 | 10MG | $399 | 2026-04-30 | Buy |
| Sigma-Aldrich | SMB00314 | Coptisine Chloride ≥98% (HPLC) | 6020-18-4 | 100MG | $1370 | 2023-06-20 | Buy |
| TCI Chemical | C3719 | Coptisine Chloride | 6020-18-4 | 25MG | $145 | 2026-04-30 | Buy |
| Cayman Chemical | 28424 | Coptisine (chloride) ≥98% | 6020-18-4 | 10mg | $134 | 2026-04-30 | Buy |
Coptisine chloride Chemical Properties,Uses,Production
Chemical Properties
Orange Brown Solid
Uses
Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.
in vivo
Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].
IC 50
IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)
Coptisine chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Tancheng Biological Technology Co., Ltd | 0311-84309789 13833149888 | tanchengchem@163.com | China | 36 | 58 |
| SiChuan HHTC Biological Technology Co., LTD | 15982498737 18380486776 | 12787973@qq.com | China | 448 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
View Lastest Price from Coptisine chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Coptisine chloride
6020-18-4
|
$95.00-293.00 | 99.42% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Coptisine chloride
6020-18-4
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2019-07-06 | Coptisine chloride
6020-18-4
|
$1.00 | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Coptisine chloride
6020-18-4
- $95.00-293.00
- 99.42%
- TargetMol Chemicals Inc.
-
- Coptisine chloride
6020-18-4
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Coptisine chloride
6020-18-4
- $1.00
- 99%
- Career Henan Chemical Co
