Coptisine chloride
- CAS No.
- 6020-18-4
- Chemical Name:
- Coptisine chloride
- Synonyms
- Q-100696;NSC-119754;Coptisine Hcl;Coptisin chloride;Coptisine choride;COPTISINE CHLORIDE;Coptisin chloride-RM;COPTISINE CHLORIDE(P);Coptisine Hydrochloride;COPTISINECHLORIDE(P)(PLEASECALL)
- CBNumber:
- CB0718668
- Molecular Formula:
- C19H14ClNO4
- Molecular Weight:
- 355.77
- MDL Number:
- MFCD00016676
- MOL File:
- 6020-18-4.mol
| Melting point | >258°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| color | Orange to Dark Orange |
| Stability | Hygroscopic |
| InChI | InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1 |
| InChIKey | LUXPUVKJHVUJAV-UHFFFAOYSA-M |
| SMILES | C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-] |
| FDA UNII | 4RSB8UY88E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H373-H301-H330-H311 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P314-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Coptisine chloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00314 | Coptisine Chloride ≥98% (HPLC) | 6020-18-4 | 25MG | $431 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHL89524 | Coptisine chloride phyproof? Reference Substance | 6020-18-4 | 10MG | $372 | 2025-07-31 | Buy |
| Sigma-Aldrich | SMB00314 | Coptisine Chloride ≥98% (HPLC) | 6020-18-4 | 100MG | $1370 | 2023-06-20 | Buy |
| TCI Chemical | C3719 | Coptisine Chloride | 6020-18-4 | 25MG | $181 | 2025-07-31 | Buy |
| Cayman Chemical | 28424 | Coptisine (chloride) | 6020-18-4 | 10mg | $121 | 2024-03-01 | Buy |
Coptisine chloride Chemical Properties,Uses,Production
Chemical Properties
Orange Brown Solid
Uses
Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.
in vivo
Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].
IC 50
IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)
Coptisine chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29854 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10242 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
View Lastest Price from Coptisine chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-19 | Coptisine chloride
6020-18-4
|
US $59.00-197.00 / mg | 98.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Coptisine chloride
6020-18-4
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | Coptisine chloride
6020-18-4
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Coptisine chloride
6020-18-4
- US $59.00-197.00 / mg
- 98.89%
- TargetMol Chemicals Inc.
-
- Coptisine chloride
6020-18-4
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Coptisine chloride
6020-18-4
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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