3,4-Difluorobenzenesulfonamide
- CAS No.
- 108966-71-8
- Chemical Name:
- 3,4-Difluorobenzenesulfonamide
- Synonyms
- BUTTPARK 21\07-17;3,4-Difluorobenzenesulfonamide;3,4-DIFLUOROBENZENESULPHONAMIDE;Benzenesulfonamide, 3,4-difluoro-;3,4-Difluorobenzenesulfonamide>Benzenesulfonamide, 3,4-difluoro- (9CI);3,4-DIFLUOROBENZENESULFONAMIDE ISO 9001：2015 REACH
- CBNumber:
- CB3397332
- Molecular Formula:
- C6H5F2NO2S
- Molecular Weight:
- 193.17
- MDL Number:
- MFCD00728800
- MOL File:
- 108966-71-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 89-93 °C (lit.) |
|---|---|
| Boiling point | 314.4±52.0 °C(Predicted) |
| Density | 1.523±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 9.79±0.60(Predicted) |
| color | White to Almost white |
| InChI | 1S/C6H5F2NO2S/c7-5-2-1-4(3-6(5)8)12(9,10)11/h1-3H,(H2,9,10,11) |
| InChIKey | VFVVRYNJTGHAIE-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1ccc(F)c(F)c1 |
| CAS DataBase Reference | 108966-71-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2935909099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3,4-Difluorobenzenesulfonamide price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559571 | 3,4-Difluorobenzenesulfonamide 97% | 108966-71-8 | 1g | $54.1 | 2023-06-20 | Buy |
| TCI Chemical | D4892 | 3,4-Difluorobenzenesulfonamide >98.0%(GC) | 108966-71-8 | 1g | $30 | 2025-07-31 | Buy |
| TCI Chemical | D4892 | 3,4-Difluorobenzenesulfonamide >98.0%(GC) | 108966-71-8 | 5g | $92 | 2025-07-31 | Buy |
| Apolloscientific | PC7245 | 3,4-Difluorobenzenesulphonamide ≥95% | 108966-71-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC7245 | 3,4-Difluorobenzenesulphonamide ≥95% | 108966-71-8 | 5g | $32 | 2026-06-04 | Buy |
3,4-Difluorobenzenesulfonamide Chemical Properties, Uses, Production
Uses
3,4-Difluorobenzenesulfonamide is an amide derivative that can be used as an organic intermediate.
Synthesis
145758-05-0
108966-71-8
Step 2: Synthesis of 3,4-difluorobenzenesulfonamide (a-3); A solution of anhydrous dichloromethane (1.5 L) of crude 3,4-difluorobenzene-1-sulfonyl chloride (a-2) (200 g, 0.92 mol) was vented with ammonia (NH3) at -30 °C. After 10 minutes of venting, formation of a white viscous substance was observed. After 30 minutes of reaction, thin layer chromatography (TLC) analysis (unfolding agent ratio of ethyl acetate: petroleum ether = 1:2) showed completion of the reaction. Subsequently, the reaction mixture was concentrated under vacuum to give the crude product. The crude product was purified by column chromatography (eluent gradient of ethyl acetate: petroleum ether = 1:5 to 1:2, and finally pure ethyl acetate) to afford the pure 3,4-difluorobenzenesulfonamide (a-3) (170 g, yield ca. 92.8%) as a white solid, which could be used in the subsequent reaction without further purification.1H NMR (400 MHz, DMSO-d6): δ 7.82 (t , J=Hz, 1H), 7.67 (m, 2H), 7.52 (s, 1H).
References
[1] Patent: WO2008/75152, 2008, A1. Location in patent: Page/Page column 33; 34
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 19, p. 3975 - 3984
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 10, p. 3098 - 3105
3,4-Difluorobenzenesulfonamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
View Latest Price from 3,4-Difluorobenzenesulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3,4-DIFLUOROBENZENESULFONAMIDE
108966-71-8
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3,4-DIFLUOROBENZENESULFONAMIDE
108966-71-8
- $9.80
- ≥99%
- Career Henan Chemical Co
108966-71-8 (3,4-Difluorobenzenesulfonamide) Related Search:
1of4
