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(+)-Bicuculline

(+)-Bicuculline structure

CAS No.: 485-49-4

Chemical Name:: (+)-Bicuculline

Synonyms: BICUCULLINE;bicucullin;Bucuculline;NSC 3219;NSC 32192);D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline-RM

CBNumber:: CB3418662

Molecular Formula:: C20H17NO6

Molecular Weight:: 367.35

MDL Number:: MFCD00005006

MOL File:: 485-49-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-17 09:03:53

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(+)-Bicuculline Properties

Melting point	193-197 °C
alpha	D25 +130.5° (CHCl3)
Boiling point	497.92°C (rough estimate)
Density	1.3694 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	2-8°C
solubility	Benzene, Chloroform, DMSO, Ethyl Acetate
pka	4.84(at 25℃)
form	Off-white to yellow powder.
color	Pale Yellow
optical activity	[α]20/D +126±6°, c = 1% in chloroform
λmax	325nm(lit.)
Merck	14,1203
BRN	98786
InChI	1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILES	[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
CAS DataBase Reference	485-49-4(CAS DataBase Reference)
FDA UNII	Y37615DVKC
EPA Substance Registry System	Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H300+H310+H330-H400

Precautionary statements

P260-P262-P273-P280-P302+P352+P310-P304+P340+P310

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T,N,Xn

Risk Statements

23/24/25-50-36/37/38-20/21/22

Safety Statements

36/37-45-61-36-26

RIDADR

UN 1544 6.1/PG 2

WGK Germany

RTECS

LV0909840

10-23

HazardClass

6.1(b)

PackingGroup

III

HS Code

29399990

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1

Toxicity

LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93

NFPA 704

	0
4		0

(+)-Bicuculline price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	25mg	$72.5	2026-04-30	Buy
Sigma-Aldrich	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	100mg	$112	2026-04-30	Buy
TCI Chemical	B1890	(+)-Bicuculline >98.0%(HPLC)(T)	485-49-4	25mg	$66	2026-04-30	Buy
TCI Chemical	B1890	(+)-Bicuculline >98.0%(HPLC)(T)	485-49-4	100mg	$195	2026-04-30	Buy
Cayman Chemical	11727	Bicuculline ≥98%	485-49-4	50mg	$49	2026-04-30	Buy

Product number	Packaging	Price	Buy
14340	25mg	$72.5	Buy
14340	100mg	$112	Buy
B1890	25mg	$66	Buy
B1890	100mg	$195	Buy
11727	50mg	$49	Buy

(+)-Bicuculline Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

GABAA receptor antagonist.

Uses

GABAa antagonist

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

Definition

ChEBI: Bicuculline is a benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. It has a role as an agrochemical, a central nervous system stimulant, a GABA-gated chloride channel antagonist, a neurotoxin and a GABAA receptor antagonist. It is an isoquinoline alkaloid, a member of isoquinolines and a benzylisoquinoline alkaloid.

General Description

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

Biological Activity

Classical GABA A antagonist.

Biochem/physiol Actions

(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

storage

+4°C

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

(+)-Bicuculline Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-Bicuculline Suppliers

Global( 361)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Ascent Scientific	60
Nanjing Chemlin Chemical Co., Ltd	64
Chemsky（shanghai）International Co.,Ltd.	50
China DongFan Chemical Co.,LTD	66
Shandong Xiya Chemical Co., Ltd	57
Sichuan Kulinan Technology Co., Ltd	57

View Lastest Price from (+)-Bicuculline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	(+)-Bicuculline USP/EP/BP 485-49-4	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2026-07-17	Bicuculline 485-49-4	$63.00		99.93%	10g	TargetMol Chemicals Inc.
2023-02-24	(+)-Bicuculline 485-49-4		5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

(+)-Bicuculline USP/EP/BP
485-49-4
$1.10
99.9%
Dideu Industries Group Limited

Bicuculline
485-49-4
$63.00
99.93%
TargetMol Chemicals Inc.

(+)-Bicuculline
485-49-4
$0.00
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

(+)-Bicuculline Spectrum

(+)-Bicuculline(485-49-4)MS (+)-Bicuculline(485-49-4)¹HNMR (+)-Bicuculline(485-49-4)¹³CNMR (+)-Bicuculline(485-49-4)IR1 (+)-Bicuculline(485-49-4)IR2

485-49-4((+)-Bicuculline)Related Search:

Kresoxim-methyl METHYL THIOPHENE-2-CARBOXYLATE Bensulfuron methyl Methylparaben Methyl acrylate

Methyl acetate POLY(D-LACTIDE) Thiophanate-methyl Methyl Parathion-methyl

Methyl bromide (-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE,(-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H],BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H] (-)-BICUCULLINE METHIODIDE BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C],BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C]

(-)-BICUCULLINE METHOCHLORIDE,(-)-BICUCULLINE METHOCHLORIDE 1(s),9(r)-(-)-bicuculline methochloride,1(S),9(R)-(-)-Bicuculline methchloride,1(s),9(r)-(-)-bicuculline methochloride,1(S),9(R)-(-)-Bicuculline methchloride (-)-BICUCULLINE METHBROMIDE

1of4

5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( d-Bicuculline/(+)-Bicuculline D-alkali than buttoned Spirit Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one (+)-Bicuculline, 99%, a GABAA antagonist furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one NSC 3219 NSC 32192) (6R)-6-[(5S)-6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one 1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv. Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))- (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one (+)-Bicuculline,98% PLUS-BICUCULLINE (+)-BICUCULLINE 1(S),9(R) (r-(r*,s*))-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6h)-one [R-(R*,S*)]-6-(5,6,7,8-TETRAHYDRO-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)FURO[3,4-E]-1,3-BENZODIOXOL-8(6H)-ONE (+)-BICUCULINE (+)-BICUCULLINE D-BICUCULLINE BICUCULLINE, (+)-(P) (+)-Bicuculline > (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one (+)-Bicuculline USP/EP/BP (+) bicuculline DISCONTINUED, offer B382500 Bicuculline (6CI, 7CI, 8CI) (+)-Bicuculline-RM (+)-Bicuculline, GABAA antagonist (+)-Bicuculline - Bio-X ? (+)-Bicuculline 98% Bicuculline (Standard) bicucullin BICUCULLINE Bucuculline 485-49-4 C20H17NO6 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Alkaloids Intermediates & Fine Chemicals Pharmaceuticals GABA/Glycine receptor GABA