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(-)-BICUCULLINE METHOBROMIDE

(-)-BICUCULLINE METHOBROMIDE Structure
(-)-BICUCULLINE METHOBROMIDE structure
CAS No.
73604-30-5
Chemical Name:
(-)-BICUCULLINE METHOBROMIDE
Synonyms
Bicuculineracemic;Bicuculinemethoiodide;(-）Bicucullinemethobromide;l-Bicuculline methobromide;(-)-BICUCULLINE METHOBROMIDE;(-)-BICUCULLINE 1(S),9(R) METHBROMIDE;( ) Bicuculline methobromide,()Bicuculline methobromide;(R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq;(6R)-6-[(5R)-6,6-diMethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-iuM-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one broMide;[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
CBNumber:
CB2461919
Molecular Formula:
C21H20NO6.Br
Molecular Weight:
462.29
MDL Number:
MFCD00055149
MOL File:
73604-30-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:35:47
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(-)-BICUCULLINE METHOBROMIDE Properties

storage temp. 2-8°C
solubility aqueous base: unstable
form solid
color white
Water Solubility Soluble in water (50mM)
Sensitive Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Environment (GHS09)
GHS06,GHS09
Signal word  Warning
Hazard statements  H301-H311-H330-H400
Precautionary statements  P301+P310a-P304+P340-P320-P330-P405-P501a
Safety Statements  24/25
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III

(-)-BICUCULLINE METHOBROMIDE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 254755 (-)-Bicuculline methobromide Asreported 73604-30-5 10mg $353 2026-06-03 Buy
Usbiological 254755 (-)-Bicuculline methobromide Asreported 73604-30-5 50mg $805 2026-06-03 Buy
ChemScene CS-0020423 (-)-Bicuculline methobromide 99.94% 73604-30-5 5mg $135 2026-06-04 Buy
ChemScene CS-0020423 (-)-Bicuculline methobromide 99.94% 73604-30-5 10mg $211 2026-06-04 Buy
ApexBio Technology B6207 (-)-Bicuculline methobromide 73604-30-5 10mg $264 2026-05-06 Buy
Product number Packaging Price Buy
254755 10mg $353 Buy
254755 50mg $805 Buy
CS-0020423 5mg $135 Buy
CS-0020423 10mg $211 Buy
B6207 10mg $264 Buy

(-)-BICUCULLINE METHOBROMIDE Chemical Properties, Uses, Production

Uses

(-)-Bicuculline methobromide is an N-methylated derivative of the GABAAantagonist bicuculline.

Biological Activity

Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

in vivo

(-)-Bicuculline methobromide can be used in animal modeling to create epilepsy models and is capable of crossing the blood-brain barrier[3].

1. Induction of epilepsy[3]
Background
(-)-Bisculline methoromide can inhibit the synthesis and release of GABA, and weaken GABA's inhibition of neuronal activity in the SN reticular region (SNr), leading to epilepsy.
Specific Mmodeling Methods
Rat: Sprague-Dawley (SD) male or female 2 weeks old
Administration: 12.5, 25, 50 or 100 ng/0.25 μL inject into SN or corpus striatum through bilateral catheter implantation
Note
(1) Dissolve (-)-Bicuculine methoromide in distilled water and administer at a volume of 0.25 μL.
(2) Simultaneously administer bilateral infusions at a rate of 0.25 μ L/min, and after the infusion is completed, insert the catheter in situ for an additional minute to prevent drug reflux.
(3) Due to the short-lived effect of (-) - Bicuculine methoromide in SN, rats were tested 5 minutes after completing the infusion.
Modeling Indicators
Behavioral observation: Shortened the latency period of epileptic seizures, causing stereotyped behaviors such as excessive sniffing or licking, chewing movements, head twitching, and slow or occasional circling.
Correlated Product(s): Muscimol (HY-N2313)
Opposite Product(s): /

Animal Model:Rat L5-SNL model[2]
Dosage:0.6 nmol/rat
Administration:Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:Attenuated the antiallodynic effect of Neurotropin.

storage

Room temperature

(-)-BICUCULLINE METHOBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-BICUCULLINE METHOBROMIDE Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Ascent Scientific 60
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
MedBioPharmaceutical Technology Inc 58
Energy Chemical 58
cjbscvictory 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

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[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINDINIUM BROMIDE [R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM BROMIDE (-)-BICUCULLINE 1(S),9(R) METHBROMIDE (-)-BICUCULLINE METHOBROMIDE Bicuculineracemic (R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq Bicuculinemethoiodide [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (6R)-6-[(5R)-6,6-diMethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-iuM-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one broMide l-Bicuculline methobromide (-）Bicucullinemethobromide ( ) Bicuculline methobromide,()Bicuculline methobromide 1,3-Dioxolo[4,5-g]isoquinolinium, 5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-, bromide (1:1), (5R)- 73604-30-5 GABA GABA/Glycine receptor