5-Bromo-2-ethoxy-4-pyridineboronic acid
- CAS No.
- 612845-46-2
- Chemical Name:
- 5-Bromo-2-ethoxy-4-pyridineboronic acid
- Synonyms
- 5-Bromo-2-ethoxy-4-pyridineboronic acid;5-BROMO-2-ETHOXYPYRIDINE-4-BORONIC ACID;5-BROMO-2-ETHOXYPYRIDIN-4-YLBORONIC ACID;(5-bromo-2-ethoxypyridin-4-yl)boronicaci;(5-Bromo-2-ethoxy-4-pyridyl)boronic acid;(3-Bromo-5-ethoxypyridin-4-yl)boronic acid;(5-Bromo-2-ethoxy-4-pyridinyl)-boronic acid;Boronic acid, (5-broMo-2-ethoxy-4-pyridinyl)- (9CI);5-Bromo-2-ethoxypyridine-4-boronicacid (contains varying amounts of Anhydride)
- CBNumber:
- CB3436356
- Molecular Formula:
- C7H9BBrNO3
- Molecular Weight:
- 245.87
- MDL Number:
- MFCD07783887
- MOL File:
- 612845-46-2.mol
- MSDS File:
- SDS
| Melting point | 103-105 °C |
|---|---|
| Boiling point | 374.8±52.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 6.88±0.58(Predicted) |
| InChI | 1S/C7H9BBrNO3/c1-2-13-7-3-5(8(11)12)6(9)4-10-7/h3-4,11-12H,2H2,1H3 |
| InChIKey | RLPXRCAGOQMYBN-UHFFFAOYSA-N |
| SMILES | CCOc1cc(B(O)O)c(Br)cn1 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
5-Bromo-2-ethoxy-4-pyridineboronic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 091157 | (5-Bromo-2-ethoxypyridin-4-yl)boronic acid | 612845-46-2 | 250.00mg | $22 | 2026-05-18 | Buy |
| Matrix Scientific | 091157 | (5-Bromo-2-ethoxypyridin-4-yl)boronic acid | 612845-46-2 | 1.00g | $74 | 2026-05-18 | Buy |
| Matrix Scientific | 091157 | (5-Bromo-2-ethoxypyridin-4-yl)boronic acid | 612845-46-2 | 5.00g | $233 | 2026-05-18 | Buy |
| aablocks | AA003BUW | 5-Bromo-2-ethoxypyridine-4-boronic acid 98% | 612845-46-2 | 250mg | $16 | 2026-05-28 | Buy |
| aablocks | AA003BUW | 5-Bromo-2-ethoxypyridine-4-boronic acid 97% | 612845-46-2 | 1g | $52 | 2026-05-28 | Buy |
5-Bromo-2-ethoxy-4-pyridineboronic acid Chemical Properties, Uses, Production
Application
5-Bromo-2-ethoxypyridine-4-boronic acid is an organic intermediate that can be used in coupling reactions such as Suzuki, and is mainly used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Synthesis
LDA (2.0 M in heptane-THF-ethylbenzene, 2.0 mL, 4.0 mmol) was added dropwise to a solution of 5-bromo-2-methoxypyridine (9) (727 mg, 3.9 mmol) in anhydrous THF (10 mL) at -78 C. The reaction mixture was stirred at -78 C for 1 h, then TIPB (1.5 g, 7.8 mmol) was added dropwise. The mixture was stirred at -78 C for 1 h, then quenched with H2O (10 mL) and allowed to warm to 20 C overnight. Post-treatment of the reaction solution (the aqueous layer was then acidified to pH 4 with 48% aqueous HBr to precipitate) gave the product 3-bromo-6-methoxy-4-pyridinylboronic acid. 5-Bromo-2-ethoxyarsenyl-4-boronic acid was synthesized with reference to the method described above from the following materials: a solution of 5-bromo-2-ethoxypyridine (10) (261 mg, 1.3 mmol), THF (10 mL), and LDA (2.0 M heptane-THF-ethylbenzene, 0.8 mL, 1.5 mmol). The product was a white solid (74 mg, 23%).
5-Bromo-2-ethoxy-4-pyridineboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-ethoxy-4-pyridineboronic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| SINO High Goal Chemical Technology Co., Ltd. | 021-57646680 18306277365 | sunkai@chembiobanksh.com | China | 2039 | 55 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
