ChemicalBook >> CAS DataBase List >>TP0463518
TP0463518
- CAS No.
- 1558021-37-6
- Chemical Name:
- TP0463518
- Synonyms
- BGE-117;TP0463518;TP0463518, 10 mM in DMSO;(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine;HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-;2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]- BGE-117
- CBNumber:
- CB34656567
- Molecular Formula:
- C20H18ClN3O6
- Molecular Weight:
- 431.83
- MDL Number:
- MOL File:
- 1558021-37-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 06:32:33
| Product description | Number | Pack Size | Price |
| TP-0463518 ≥98% | 33788 | 5mg | $53 |
| TP-0463518 ≥98% | 33788 | 10mg | $98 |
| TP-0463518 ≥98% | 33788 | 25mg | $194 |
| TP-0463518 ≥98% | 33788 | 50mg | $332 |
| TP0463518 | IMC02137 | 25mg | $1345.25 |
| More product size | |||
| Boiling point | 775.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.512±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM) |
| form | A solid |
| pka | 3.63±0.10(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | V65GPE6NTB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TP0463518 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33788 | TP-0463518 ≥98% | 1558021-37-6 | 5mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 33788 | TP-0463518 ≥98% | 1558021-37-6 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 33788 | TP-0463518 ≥98% | 1558021-37-6 | 25mg | $194 | 2026-04-30 | Buy |
| Cayman Chemical | 33788 | TP-0463518 ≥98% | 1558021-37-6 | 50mg | $332 | 2026-04-30 | Buy |
| Biosynth | IMC02137 | TP0463518 | 1558021-37-6 | 25mg | $1345.25 | 2026-06-04 | Buy |
TP0463518 Chemical Properties,Uses,Production
Uses
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].
References
[1] Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144. DOI:10.1016/j.ejphar.2018.08.044
TP0463518 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7750 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
TP0463518
Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
BGE-117
HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors
2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
TP0463518, 10 mM in DMSO
(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine
Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
BGE-117
1558021-37-6
1558021-37-0
