JHU-083
- CAS No.
- 1998725-11-3
- Chemical Name:
- JHU-083
- Synonyms
- T15613;JHU-083;JHU-083 ，S8891;JHU083;JHU 083
- CBNumber:
- CB34668069
- Molecular Formula:
- C14H24N4O4
- Molecular Weight:
- 312.37
- MDL Number:
- MOL File:
- 1998725-11-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
JHU-083 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40642 | JHU083 ≥98% | 1998725-11-3 | 500μg | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 40642 | JHU083 ≥98% | 1998725-11-3 | 1mg | $283 | 2026-04-30 | Buy |
| Biosynth | YED72511 | JHU-083 | 1998725-11-3 | 5mg | $1315.6 | 2026-06-05 | Buy |
| Biosynth | YED72511 | JHU-083 | 1998725-11-3 | 10mg | $2104.9 | 2026-06-05 | Buy |
| Biosynth | YED72511 | JHU-083 | 1998725-11-3 | 25mg | $3946.75 | 2026-06-05 | Buy |
JHU-083 Chemical Properties, Uses, Production
Uses
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].
in vivo
JHU-083 (1.82 mg/kg; PO; every other day for 12 days) ameliorates social avoidance behavior and anhedonia-like behavior induced by CSDS[1].
JHU-083 (1.82 mg/kg, PO) attenuates CSDS-induced increase in glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but not in the cerebellum. JHU-083 treatment suppresses the CSDS-induced upregulation of IL-1β and TNF-α expression[1].
| Animal Model: | Male 7-to 8-week-old C57BL/6J (C57) mice (25-30g) with chronic social defeat stress (CSDS)[1] |
| Dosage: | 1.82mg/kg |
| Administration: | PO; every other day for 12 days |
| Result: | Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS. |
References
[1] Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. DOI:10.1038/s41386-018-0177-7
[2] Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. DOI:10.1073/pnas.1812909115
JHU-083 Preparation Products And Raw materials
JHU-083 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Shanghai Maruhua Science and Technology Co. Ltd. | 18721745940 | sales2@api-chem.com | China | 1968 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
