| Company Name: |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
|
| Tel: |
17702719238 18971495150; |
| Email: |
sales@sun-shinechem.com |
| Products Intro: |
Product Name:JHU-083
CAS:1998725-11-3
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
|
JHU-083 manufacturers
- JHU-083
-
- $1460.00 / 25mg
-
2025-10-27
- CAS:1998725-11-3
- Min. Order:
- Purity: 99.53%
- Supply Ability: 10g
|
| | JHU-083 Basic information |
| | JHU-083 Chemical Properties |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | DMSO: 100 mg/mL (320.14 mM) | | form | Solid | | color | Light yellow to yellow |
| | JHU-083 Usage And Synthesis |
| Uses | JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2]. | | in vivo | JHU-083 (1.82 mg/kg; PO; every other day for 12 days) ameliorates social avoidance behavior and anhedonia-like behavior induced by CSDS[1].
JHU-083 (1.82 mg/kg, PO) attenuates CSDS-induced increase in glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but not in the cerebellum. JHU-083 treatment suppresses the CSDS-induced upregulation of IL-1β and TNF-α expression[1].
| Animal Model: | Male 7-to 8-week-old C57BL/6J (C57) mice (25-30?g) with chronic social defeat stress (CSDS)[1] | | Dosage: | 1.82?mg/kg | | Administration: | PO; every other day for 12 days | | Result: | Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
|
| | References | [1] Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. DOI:10.1038/s41386-018-0177-7
[2] Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. DOI:10.1073/pnas.1812909115 |
| | JHU-083 Preparation Products And Raw materials |
|