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6-Phenyl-3(2H)-pyridazinone

6-Phenyl-3(2H)-pyridazinone structure

CAS No.: 2166-31-6

Chemical Name:: 6-Phenyl-3(2H)-pyridazinone

Synonyms: 6-phenylpyridazin-3(2H)-one;IFLAB-BB F0921-7014;3-Phenyl-6-pyridazinone;6-Phenyl-2H-pyridazin-3-one;3-phenyl-1H-pyridazin-6-one;6-Phenyl-3(2H)-pyridazinone;3-Hydroxy-6-phenylpyridazine;3(2H)-Pyridazinone, 6-phenyl-;6-Phenyl-3(2H)-pyridazinone>6-Phenyl-3(2H)-pyridazinone

CBNumber:: CB3468980

Molecular Formula:: C10H8N2O

Molecular Weight:: 172.18

MDL Number:: MFCD00114953

MOL File:: 2166-31-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:04

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6-Phenyl-3(2H)-pyridazinone Properties

Melting point	201-204 °C(lit.)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	11.05±0.40(Predicted)
color	White to Light yellow
λmax	249nm(HCl aq.)(lit.)
InChI	InChI=1S/C10H8N2O/c13-10-7-6-9(11-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)
InChIKey	IJUIPRDMWWBTTQ-UHFFFAOYSA-N
SMILES	C1(=O)NN=C(C2=CC=CC=C2)C=C1
FDA UNII	4XCL934PMP
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

2933998090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
1		0

6-Phenyl-3(2H)-pyridazinone price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	510602	6-Phenyl-3(2H)-pyridazinone 98%	2166-31-6	5g	$243	2023-01-07	Buy
TCI Chemical	P2060	6-Phenyl-3(2H)-pyridazinone >98.0%(GC)	2166-31-6	1g	$109	2026-04-30	Buy
TCI Chemical	P2060	6-Phenyl-3(2H)-pyridazinone >98.0%(GC)	2166-31-6	5g	$432	2024-03-01	Buy
Apolloscientific	OR14974	6-Phenylpyridazin-3(2H)-one >98%	2166-31-6	250mg	$21	2026-06-04	Buy
Apolloscientific	OR14974	6-Phenylpyridazin-3(2H)-one >98%	2166-31-6	1g	$24	2026-06-04	Buy

Product number	Packaging	Price	Buy
510602	5g	$243	Buy
P2060	1g	$109	Buy
P2060	5g	$432	Buy
OR14974	250mg	$21	Buy
OR14974	1g	$24	Buy

6-Phenyl-3(2H)-pyridazinone Chemical Properties, Uses, Production

Uses

6-Phenylpyridazin-3(2H)-one is a reagent in the preparation of cyclase activator Runcaciguat, a compound used in the treatment of kidney disease and non-proliferative diabetic retinopathy.

General Description

6-Phenyl-3(2H)-pyridazinone is a pyridazinone derivative that can be prepared from 4,5- dihydro-6-phenyl-3(2H)-pyridazinone. It is reported to be a weak positive inotropic agent. 6-Phenyl-3(2H)-pyridazinone forms the core of compounds that show a potential antiplatelet activity.

Synthesis

98-86-2

298-12-4

2166-31-6

The reaction of 19.6 g (162.95 mmol) acetophenone and 5 g (54.32 mmol) oxaloacetic acid monohydrate was stirred at 100 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to 40 °C, followed by the addition of 20 mL of water and 4 mL of ammonia. The mixture was extracted twice with 50 mL of dichloromethane. To the resulting aqueous phase, 2.64 mL (53.32 mmol) of hydrazine monohydrate was added, and the reaction was continued with stirring of the mixture at 100 °C for 2 hours. At the end of the reaction, the reaction solution was cooled to room temperature. The precipitated crystals were collected by filtration, washed with water and dried in a vacuum oven at 50 °C overnight. Finally, 4.3 g (24.97 mmol, 15% yield) of 6-phenyl-3-pyridazinone was obtained as colorless crystals.LC-MS (Method 7): Rt = 1.39 min; m/z = 173 (M + H)+. 1H-NMR (400 MHz, DMSO-d6, δ/ppm): 13.2 (s, 1H), 8.04 (d, 1H), 7.86 (d, 2H), 7.53-7.41 (m, 3H), 7.00 (d, 1H).

References

[1] Patent: US2011/34450, 2011, A1. Location in patent: Page/Page column 103
[2] Patent: US2012/28971, 2012, A1. Location in patent: Page/Page column 24-25
[3] Synthesis, 1993, # 3, p. 334 - 342
[4] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2553 - 2560
[5] Letters in Drug Design and Discovery, 2013, vol. 10, # 6, p. 507 - 514

6-Phenyl-3(2H)-pyridazinone Preparation Products And Raw materials

Raw materials

Glycolic acid Acetophenone Glyoxylic acid Hydrazine hydrate Ammonia

Preparation Products

3,5-Dichloro-6-phenylpyridazine 3-(6-oxo-3-phenylpyridazin-1(6H)-yl)propanoic acid (6-Oxo-3-phenylpyridazin-1(6H)-yl)acetic acid 4-Amino-6-phenyl-3(2H)-pyridazinone

6-Phenyl-3(2H)-pyridazinone Suppliers

Global Suppliers ( 134)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianyuan Natural Product Co.,Ltd.	028-85012281 13808177790	xianlihong8888@163.com	China	45	62
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
Cantotech Chemicals, Ltd.	86-0755-86635001	cantotech@126.com	China	4554	55

Supplier	Advantage
Tianyuan Natural Product Co.,Ltd.	62
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Jia Xing Isenchem Co.,Ltd	66
Tetranov Biopharm	64
Shanghai Hanhong Scientific Co.,Ltd.	64
China DongFan Chemical Co.,LTD	66
Shanghai T&W Pharmaceutical Co., Ltd.	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
Cantotech Chemicals, Ltd.	55

View Latest Price from 6-Phenyl-3(2H)-pyridazinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	6-PHENYL-3(2H)-PYRIDAZINONE 2166-31-6	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-01-04	3-phenyl-1H-pyridazin-6-one 2166-31-6		1g	98%minHPLC	100kgs/month	Shanghai Rlavie Technology Co ltd
2019-07-10	6-PHENYL-3(2H)-PYRIDAZINONE 2166-31-6	$1.00	1KG	98%	150KG	Career Henan Chemical Co

6-PHENYL-3(2H)-PYRIDAZINONE
2166-31-6
$1.10
99.00%
Dideu Industries Group Limited

3-phenyl-1H-pyridazin-6-one
2166-31-6
98%minHPLC
Shanghai Rlavie Technology Co ltd

6-PHENYL-3(2H)-PYRIDAZINONE
2166-31-6
$1.00
98%
Career Henan Chemical Co

6-Phenyl-3(2H)-pyridazinone Spectrum

6-PHENYL-3(2H)-PYRIDAZINONE(2166-31-6)¹HNMR 6-PHENYL-3(2H)-PYRIDAZINONE(2166-31-6)IR

2166-31-6 (6-Phenyl-3(2H)-pyridazinone) Related Search:

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6-Phenyl-2,3-dihydropyridazine-3-one 3-phenyl-1H-pyridazin-6-one 3-Phenyl-6-pyridazinone 2,3-Dihydro-3-oxo-6-phenylpyridazine, (6-Oxo-1,6-dihydropyridazin-3-yl)benzene 6-Phenyl-3(2H)-pyridazinone 8-(2-hydroxypropan-2-yl)-2-furo[2,3-h][1]benzopyranone JR-8471, 6-Phenyl-3-(2H)-pyridazinone, 97% IFLAB-BB F0921-7014 6-Phenyl-2H-pyridazin-3-one 6-Phenyl-3(2H)-pyridazinone> 3(2H)-Pyridazinone, 6-phenyl- 3-Hydroxy-6-phenylpyridazine 6-PHENYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH 6-phenylpyridazin-3(2H)-one 6-Phenyl-3(2H)-pyridazinone 2166-31-6 Pyridazines Heterocyclic Building Blocks Building Blocks Building Blocks Heterocyclic Building Blocks Pyridazines