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4-Fluorobenzyl bromide

4-Fluorobenzyl bromide structure

CAS No.: 459-46-1

Chemical Name:: 4-Fluorobenzyl bromide

Synonyms: 1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE;A-BROMO-4-FLUOROTOLUENE

CBNumber:: CB3471414

Molecular Formula:: C7H6BrF

Molecular Weight:: 189.02

MDL Number:: MFCD00000359

MOL File:: 459-46-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:33:09

Product description	Number	Pack Size	Price
4-Fluorobenzyl bromide 97%	209538	5g	$45.4
4-Fluorobenzyl bromide 97%	209538	25g	$122
4-Fluorobenzyl Bromide >97.0%(GC)	F0214	5g	$28
4-Fluorobenzyl Bromide >97.0%(GC)	F0214	25g	$77
4-Fluorobenzyl bromide 98%	1700-B-08	500g	$186
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4-Fluorobenzyl bromide Properties

Boiling point	85 °C15 mm Hg(lit.)
Density	1.517 g/mL at 25 °C(lit.)
refractive index	n20/D 1.547(lit.)
Flash point	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Chloroform
form	Liquid
Specific Gravity	1.517
color	Clear colorless to yellow
Sensitive	Lachrymatory
BRN	636507
InChI	1S/C7H6BrF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2
InChIKey	NVNPLEPBDPJYRZ-UHFFFAOYSA-N
SMILES	Fc1ccc(CBr)cc1
CAS DataBase Reference	459-46-1(CAS DataBase Reference)
FDA UNII	GKL3GW5GWH
NIST Chemistry Reference	«alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System	4-Fluorobenzyl bromide (459-46-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

34-36

Safety Statements

26-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

Hazard Note

Corrosive/Lachrymatory

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29039990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	0
3		0

4-Fluorobenzyl bromide price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	209538	4-Fluorobenzyl bromide 97%	459-46-1	5g	$45.4	2026-04-30	Buy
Sigma-Aldrich	209538	4-Fluorobenzyl bromide 97%	459-46-1	25g	$122	2026-04-30	Buy
TCI Chemical	F0214	4-Fluorobenzyl Bromide >97.0%(GC)	459-46-1	5g	$28	2026-04-30	Buy
TCI Chemical	F0214	4-Fluorobenzyl Bromide >97.0%(GC)	459-46-1	25g	$77	2026-04-30	Buy
SynQuest Laboratories	1700-B-08	4-Fluorobenzyl bromide 98%	459-46-1	500g	$186	2026-05-22	Buy

Product number	Packaging	Price	Buy
209538	5g	$45.4	Buy
209538	25g	$122	Buy
F0214	5g	$28	Buy
F0214	25g	$77	Buy
1700-B-08	500g	$186	Buy

4-Fluorobenzyl bromide Chemical Properties,Uses,Production

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

Uses

4-Fluorobenzyl bromide was used in the preparation of:

3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
8-bromo 9-(4-fluorobenzyl) adenine
8-bromo 3-(4-fluorobenzyl) adenine

Synthesis

459-56-3

459-46-1

GENERAL METHOD: Benzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, the target product 4-fluorobenzyl bromide was obtained in quantitative yield by conventional post-processing steps.

References

[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309
[3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Chem, 2018, vol. 4, # 1, p. 124 - 137

4-Fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

4-Fluorobenzyl alcohol p-Fluorotoluene Phosphorus tribromide Benzene

Preparation Products

4-Fluorobenzyl alcohol 2-IODOBENZAMIDE (4-FLUORO-BENZYL)-METHYL-AMINE 1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE N,N-Bis(2-chloroethyl)-p-fluorobenzylamine

1-[(4-fluorophenyl)methyl]imidazole 4-(4-Fluoro-benzyloxy)-benzonitrile 1-[(4-fluorophenyl)methyl]pyrrolidin-3-ol

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4-Fluorobenzyl bromide Suppliers

Global( 428)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5231	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58

View Lastest Price from 4-Fluorobenzyl bromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	4-Fluorobenzyl bromide 459-46-1	$10.00	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	4-Fluorobenzyl Bromide 459-46-1	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Fluorobenzyl bromide 459-46-1	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd

4-Fluorobenzyl bromide
459-46-1
$10.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

4-Fluorobenzyl Bromide
459-46-1
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Fluorobenzyl bromide
459-46-1
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

4-Fluorobenzyl bromide Spectrum

4-Fluorobenzyl bromide(459-46-1)MS 4-Fluorobenzyl bromide(459-46-1)¹HNMR 4-Fluorobenzyl bromide(459-46-1)IR1 4-Fluorobenzyl bromide(459-46-1)Raman

459-46-1(4-Fluorobenzyl bromide)Related Search:

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Allyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene Rocuronium bromide [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate

Diethylstilbestrol 4-n-Propoxyphenylacetylene 1,2-Bis(bromomethyl)benzene 9-BROMOFLUORENE 2-(Trifluoromethyl)benzyl bromide

1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE Bromine Methyl bromide

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P-FLUOROBENZYL BROMIDE 4-Fluoro-1-(bromomethyl)benzene α-Bromo-4-fluorotoluene 4-Fluorobenzyl bromi BroMobenzene of fluoride Of fluoride broMide 1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene Toluene, α-broMo-p-fluoro- (6CI,7CI,8CI) The fluorine broMine benzyl ALPHA-BROMO-P-FLUOROTOLUENE ALPHA-BROMO-4-FLUOROTOLUENE 4-FLUOROBENZYL BROMIDE 1-(bromomethyl)-4-fluoro-benzen Benzene, 1-(bromomethyl)-4-fluoro- Toluene, alpha-bromo-p-fluoro- 4-fluoro(bromomethyl)benzene 1-bromo-3-fluorotoluene à-bromo-4-fluorotoluene 4-Fluorobenzyl bromide 90% 4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide 4-FLUOROBENZYL BROMIDE 98% (GC) 4-Fluorobenzylbromide,97% α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene 4-Fluorobenzyl bromide ,98% 4-FLUOROBBENZYL BROMIDE A-BROMO-4-FLUOROTOLUENE 4-FluorobenzylBromide> 4-Fluorobenzyl bromide, 98%, for synthesis 4-Fluorobenzyl bromide ISO 9001：2015 REACH α-Bromo-p-fluorotoluene 1-(BROMOMETHYL)-4-FLUOROBENZENE 459-46-1 BENZYL HALIDE Building Blocks Aryl C7 Halogenated Hydrocarbons Organic Building Blocks Benzyl Fluoro-contained benzyl bromide series alkyl bromide|alkyl Fluorine Halogenated Heterocycles ,Pyrimidines Fluorinated benzene series bc0001