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4-Fluorobenzyl bromide

4-Fluorobenzyl bromide Structure
4-Fluorobenzyl bromide structure
CAS No.
459-46-1
Chemical Name:
4-Fluorobenzyl bromide
Synonyms
1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE;A-BROMO-4-FLUOROTOLUENE
CBNumber:
CB3471414
Molecular Formula:
C7H6BrF
Molecular Weight:
189.02
MDL Number:
MFCD00000359
MOL File:
459-46-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:33:09
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4-Fluorobenzyl bromide Properties

Boiling point 85 °C15 mm Hg(lit.)
Density 1.517 g/mL at 25 °C(lit.)
refractive index n20/D 1.547(lit.)
Flash point >230 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Chloroform
form Liquid
Specific Gravity 1.517
color Clear colorless to yellow
Sensitive Lachrymatory
BRN 636507
InChI 1S/C7H6BrF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2
InChIKey NVNPLEPBDPJYRZ-UHFFFAOYSA-N
SMILES Fc1ccc(CBr)cc1
CAS DataBase Reference 459-46-1(CAS DataBase Reference)
FDA UNII GKL3GW5GWH
NIST Chemistry Reference «alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System 4-Fluorobenzyl bromide (459-46-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34-36
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
Hazard Note  Corrosive/Lachrymatory
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29039990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
3 0

4-Fluorobenzyl bromide price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 209538 4-Fluorobenzyl bromide 97% 459-46-1 5g $45.4 2026-04-30 Buy
Sigma-Aldrich 209538 4-Fluorobenzyl bromide 97% 459-46-1 25g $122 2026-04-30 Buy
TCI Chemical F0214 4-Fluorobenzyl Bromide >97.0%(GC) 459-46-1 5g $28 2026-04-30 Buy
TCI Chemical F0214 4-Fluorobenzyl Bromide >97.0%(GC) 459-46-1 25g $77 2026-04-30 Buy
TRC TRC-F588610-5G 4-Fluorobenzyl Bromide 459-46-1 5g $59 2026-06-03 Buy
Product number Packaging Price Buy
209538 5g $45.4 Buy
209538 25g $122 Buy
F0214 5g $28 Buy
F0214 25g $77 Buy
TRC-F588610-5G 5g $59 Buy

4-Fluorobenzyl bromide Chemical Properties, Uses, Production

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

Uses

4-Fluorobenzyl bromide was used in the preparation of:

  • 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
  • 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
  • (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
  • 8-bromo 9-(4-fluorobenzyl) adenine
  • 8-bromo 3-(4-fluorobenzyl) adenine

Synthesis

4-Fluorobenzyl alcohol

459-56-3

4-Fluorobenzyl bromide

459-46-1

GENERAL METHOD: Benzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, the target product 4-fluorobenzyl bromide was obtained in quantitative yield by conventional post-processing steps.

References

[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309
[3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Chem, 2018, vol. 4, # 1, p. 124 - 137

4-Fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

4-Fluorobenzyl alcohol p-Fluorotoluene Phosphorus tribromide Benzene

Preparation Products

4-Fluorobenzyl alcohol 2-Iodobenzamide (4-Fluoro-benzyl)-methyl-amine 1-(4-Fluoro-benzyl)-1H-pyrazol-3-ylamine N,N-Bis(2-chloroethyl)-p-fluorobenzylamine
1-[(4-fluorophenyl)methyl]imidazole 4-(4-Fluoro-benzyloxy)-benzonitrile 1-[(4-fluorophenyl)methyl]pyrrolidin-3-ol

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4-Fluorobenzyl bromide Suppliers

Global Suppliers ( 437)
Supplier Tel Email Country ProdList Advantage
Fuxin Simai Chemical Technology Co., Ltd. 13841818553 929964679@qq.com China 446 58
Huangshi Jingchi?Medicine?Co.,?Ltd 17771967576; 17771967576 234107690@qq.com China 609 58
Wuhan Nuobiguo Biotechnology Co., Ltd. 15972140806 15972140806 3850656479@qq.com China 294 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing dtftchem Technology Co., Ltd. 010-60275820 13031183356 elainezt@sina.com China 1386 62
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Supplier Advantage
Fuxin Simai Chemical Technology Co., Ltd. 58
Huangshi Jingchi?Medicine?Co.,?Ltd 58
Wuhan Nuobiguo Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Liaoning Tianhua Chemical Co., Ltd. 69
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing dtftchem Technology Co., Ltd. 62
Beijing HwrkChemical Technology Co., Ltd 55

View Latest Price from 4-Fluorobenzyl bromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Fluorobenzyl bromide pictures 2026-09-02 4-Fluorobenzyl bromide
459-46-1
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Fluorobenzyl bromide pictures 2026-05-28 4-Fluorobenzyl bromide
459-46-1
 $10.00 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
4-Fluorobenzyl Bromide pictures 2026-03-20 4-Fluorobenzyl Bromide
459-46-1
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

4-Fluorobenzyl bromide Spectrum

4-Fluorobenzyl bromide(459-46-1)MS4-Fluorobenzyl bromide(459-46-1)1HNMR4-Fluorobenzyl bromide(459-46-1)IR14-Fluorobenzyl bromide(459-46-1)Raman

459-46-1 (4-Fluorobenzyl bromide) Related Search:

Ethyl bromodifluoroacetate Fluorobenzene Ethidium bromide 4-Fluorobenzyl chloride BRETYLIUM TOSYLATE
Allyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene Rocuronium bromide [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate
Diethylstilbestrol 4-n-Propoxyphenylacetylene 1,2-Bis(bromomethyl)benzene 2-(Trifluoromethyl)benzyl bromide Bromine
9-Bromofluorene 1,2,4,5-Tetrakis(bromomethyl)benzene Methyl bromide

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P-FLUOROBENZYL BROMIDE 4-Fluoro-1-(bromomethyl)benzene α-Bromo-4-fluorotoluene 4-Fluorobenzyl bromi BroMobenzene of fluoride Of fluoride broMide 1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene Toluene, α-broMo-p-fluoro- (6CI,7CI,8CI) The fluorine broMine benzyl ALPHA-BROMO-P-FLUOROTOLUENE ALPHA-BROMO-4-FLUOROTOLUENE 4-FLUOROBENZYL BROMIDE 1-(bromomethyl)-4-fluoro-benzen Benzene, 1-(bromomethyl)-4-fluoro- Toluene, alpha-bromo-p-fluoro- 4-fluoro(bromomethyl)benzene 1-bromo-3-fluorotoluene à-bromo-4-fluorotoluene 4-Fluorobenzyl bromide 90% 4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide 4-FLUOROBENZYL BROMIDE 98% (GC) 4-Fluorobenzylbromide,97% α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene 4-Fluorobenzyl bromide ,98% 4-FLUOROBBENZYL BROMIDE A-BROMO-4-FLUOROTOLUENE 4-FluorobenzylBromide> 4-Fluorobenzyl bromide, 98%, for synthesis 4-Fluorobenzyl bromide ISO 9001：2015 REACH α-Bromo-p-fluorotoluene 1-(BROMOMETHYL)-4-FLUOROBENZENE 459-46-1 BENZYL HALIDE Building Blocks Aryl C7 Halogenated Hydrocarbons Organic Building Blocks Benzyl Fluoro-contained benzyl bromide series alkyl bromide|alkyl Fluorine Halogenated Heterocycles ,Pyrimidines Fluorinated benzene series bc0001