JAK1 ANTIBODY

Source

Rabbit

Reactivity

Human;Mouse

Background

Members of the Janus family of tyrosine kinases are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats, Shc, insulin receptor substrates, and focal adhesion kinase, typically contain SH2 or other phospho-tyrosine-binding domains.

References

[1] Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322.
[2] Darnell, J.E. (1997) Science 277, 1630-5.
[3] VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
[4] Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
[5] Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.

Raw materials

Preparation Products