Metoclopramide-d3
- CAS No.
- 1216522-89-2
- Chemical Name:
- Metoclopramide-d3
- Synonyms
- Metoclopramide-d3;[2H3]-Metoclopramide;4-AMino-5-chloro-N-[2-(diethylaMino)ethyl]-2-(Methoxy-d3)benzaMide;4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(trideuteriomethoxy)benzamide;Metoclopramide D3Q: What is Metoclopramide D3 Q: What is the CAS Number of Metoclopramide D3 Q: What is the storage condition of Metoclopramide D3 Q: What are the applications of Metoclopramide D3
- CBNumber:
- CB3473786
- Molecular Formula:
- C14H19ClD3N3O2
- Molecular Weight:
- 302.81
- MDL Number:
- MFCD08063630
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Metoclopramide-d3 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28885 | Metoclopramide-d3 ≥99%deuteratedforms(d1-d3) | 1216522-89-2 | 500μg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 28885 | Metoclopramide-d3 ≥99%deuteratedforms(d1-d3) | 1216522-89-2 | 1mg | $127 | 2026-04-30 | Buy |
| Usbiological | M3580 | Metoclopramide-O-methyl-d3 | 1216522-89-2 | 5mg | $761 | 2026-06-03 | Buy |
| TRC | TRC-M338687-5MG | Metoclopramide-d3 >95%(HPLC) | 1216522-89-2 | 5mg | $278 | 2026-06-03 | Buy |
| TRC | TRC-M338687-50MG | Metoclopramide-d3 >95%(HPLC) | 1216522-89-2 | 50mg | $2000 | 2026-06-03 | Buy |
Metoclopramide-d3 Chemical Properties,Uses,Production
Description
Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide by GC- or LC-MS. Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.
Chemical Properties
White Crystalline Solid
Uses
Labelled dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.
References
[1] Y. HIROKAWA. Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist.[J]. Chemical & pharmaceutical bulletin, 2002, 110 1: 941-959. DOI: 10.1248/cpb.50.941
[2] JRG-MICHAEL CHEMNITIUS . INDIRECT PARASYMPATHOMIMETIC ACTIVITY OF METOCLOPRAMIDE: REVERSIBLE INHIBITION OF CHOLINESTERASES FROM HUMAN CENTRAL NERVOUS SYSTEM AND BLOOD[J]. Pharmacological research, 1996, 34 1: Pages 65-72. DOI: 10.1006/phrs.1996.9999
[3] R. D. YOUSSEFYEH. Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides[J]. Journal of Medicinal Chemistry, 1992, 35 5: 895-903. DOI: 10.1021/jm00083a014
[4] C A ALTAR. Dopamine neurochemical profile of atypical antipsychotics resembles that of D-1 antagonists.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1988, 338 2: 162-168. DOI: 10.1007/bf00174864
Metoclopramide-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TOSUN PHARM | 020-66392521-118 18922260391 | 3004261881@qq.com | China | 7994 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Guangzhou Austine Biotechnology Co., LTD | 15918640830 13268843209 | 1947181658@qq.com | China | 9032 | 58 |
