P18IN011
- CAS No.
- 77408-67-4
- Chemical Name:
- P18IN011
- Synonyms
- P18IN011;P18IN011,P-18IN011;P18IN011, 10 mM in DMSO;P18IN011 - CAS 77408-67-4 - Calbiochem;1,2-benzoxazol-3-yl 4-acetamidobenzene-1-sulfonate;Benzenesulfonic acid, 4-(acetylamino)-, 1,2-benzisoxazol-3-yl ester
- CBNumber:
- CB34813971
- Molecular Formula:
- C15H12N2O5S
- Molecular Weight:
- 332.33
- MDL Number:
- MOL File:
- 77408-67-4.mol
- MSDS File:
- SDS
| Melting point | 143-144 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
|---|---|
| Boiling point | 609.3±51.0 °C(Predicted) |
| Density | 1.468±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 50mg/mL |
| pka | 13.85±0.70(Predicted) |
| form | solid |
| color | white |
| InChI | 1S/C15H12N2O5S/c1-10(18)16-11-6-8-12(9-7-11)23(19,20)22-15-13-4-2-3-5-14(13)21-17-15/h2-9H,1H3,(H,16,18) |
| InChIKey | SIXNKGXJEIVCDH-UHFFFAOYSA-N |
| SMILES | [S](=O)(=O)(Oc2n[o]c3c2cccc3)c1ccc(cc1)NC(=O)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
P18IN011 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.38094 | P18IN011 - CAS 77408-67-4 - Calbiochem | 77408-67-4 | 25mg | $168 | 2025-07-31 | Buy |
| Biosynth | CDA40867 | 1,2-Benzoxazol-3-yl 4-acetamidobenzene-1-sulfonate | 77408-67-4 | 50mg | $434 | 2026-06-04 | Buy |
| Biosynth | CDA40867 | 1,2-Benzoxazol-3-yl 4-acetamidobenzene-1-sulfonate | 77408-67-4 | 0.5g | $1309.8 | 2026-06-04 | Buy |
| Ambeed | A1258513 | P18IN011 95% | 77408-67-4 | 50mg | $219 | 2026-06-05 | Buy |
| Ambeed | A1258513 | P18IN011 95% | 77408-67-4 | 100mg | $318 | 2026-06-05 | Buy |
P18IN011 Chemical Properties, Uses, Production
Uses
A cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED50 of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Biological Activity
Cell permeable: yes', 'Primary Target
p18', 'Reversible: yes
P18IN011 Preparation Products And Raw materials
Raw materials
Preparation Products
P18IN011 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11432 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
