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CP-544439

CP-544439 Structure
CP-544439 structure
CAS No.
230954-09-3
Chemical Name:
CP-544439
Synonyms
CP-544439;UNII-516DO4KL5R;CP 544439,CP544439;2H-Pyran-4-carboxamide, 4-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]tetrahydro-N-hydroxy-
CBNumber:
CB34919684
Molecular Formula:
C18H19FN2O6S
Molecular Weight:
410.42
MDL Number:
MFCD34567141
MOL File:
230954-09-3.mol
Last updated:2025-04-18 09:52:07
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CP-544439 Properties

FDA UNII 516DO4KL5R

CP-544439 Chemical Properties,Uses,Production

Uses

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].

in vivo

In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1].

IC 50

MMP-13: 0.75 nM (IC50); MMP-12: 0.24 nM (IC50); MMP-1: 420 nM (IC50); MMP-2: 1.6 nM (IC50); MMP-3: 16 nM (IC50); MMP-8: 1.4 nM (IC50); MMP-9: 12 nM (IC50); MMP-14: 7.4 nM (IC50)

References

[1] Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profil DOI:10.1124/dmd.108.022566
[2] Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. DOI:10.1016/j.bmcl.2004.04.083

CP-544439 Preparation Products And Raw materials

Raw materials

Preparation Products

CP-544439 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19965 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from CP-544439 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP-544439 pictures 2024-11-11 CP-544439
230954-09-3
 US $293.00-987.00 / mg 98.11% 10g TargetMol Chemicals Inc.
  • CP-544439 pictures
  • CP-544439
    230954-09-3
  • US $293.00-987.00 / mg
  • 98.11%
  • TargetMol Chemicals Inc.
CP-544439 2H-Pyran-4-carboxamide, 4-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]tetrahydro-N-hydroxy- UNII-516DO4KL5R CP 544439,CP544439 230954-09-3 C18H19FN2O6S