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CC-618

CC-618 Structure
CC-618 structure
CAS No.
1680204-90-3
Chemical Name:
CC-618
Synonyms
CC-618;CC618,CC-618;CC618, 10 mM in DMSO;4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-5-thiazolecarboxamide;5-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-
CBNumber:
CB34919851
Molecular Formula:
C20H15F6N3O3S2
Molecular Weight:
523.47
MDL Number:
MOL File:
1680204-90-3.mol
Last updated:2025-04-28 21:36:36
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CC-618 Properties

Density 1.466±0.06 g/cm3(Predicted)
pka 9.39±0.46(Predicted)
form Solid
color White to off-white

CC-618 Chemical Properties,Uses,Production

Description

CC618 is a potent and selective PPARβ/δ antagonist. CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. The treatment of PPARβ/δ with CC618 leads to a covalent modification of Cys249, located centrally in the PPARβ/δ ligand binding pocket, corresponding to the conversion of its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether.

Uses

CC618 is a selective peroxisome proliferator-activated receptor (PPARβ/δ) antagonist that exhibits antagonism by covalently binding to PPARβ/δ receptors[1].

References

[1] Kaupang ?, et al. Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. Eur J Med Chem. 2015 Apr 13;94:229-36. DOI:10.1016/j.ejmech.2015.03.006

CC-618 Preparation Products And Raw materials

Raw materials

Preparation Products

CC-618 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9342 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 947 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24863 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7328 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29998 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58

View Lastest Price from CC-618 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CC618 pictures 2025-04-27 CC618
1680204-90-3
 US $117.00-388.00 / mg 99.37% 10g TargetMol Chemicals Inc.
  • CC618 pictures
  • CC618
    1680204-90-3
  • US $117.00-388.00 / mg
  • 99.37%
  • TargetMol Chemicals Inc.

CC-618 Spectrum

CC-618(1680204-90-3)1HNMR
CC-618 5-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]- CC618,CC-618 CC618, 10 mM in DMSO 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-5-thiazolecarboxamide 1680204-90-3 C20H15F6N3O3S2