4-Aminophenyl-1-phenethylpiperidine
- CAS No.
- 21409-26-7
- Chemical Name:
- 4-Aminophenyl-1-phenethylpiperidine
- Synonyms
- 4-ANPP;Fentanyl Related Compound E;TBC-5487;4-ANPP (CRM);4-ANPP solution;Depropionylfentanyl;Fentanyl Impurity D;Fentanyl Citrate Impurity D;Fentanyl Citrate EP Impurity D;Fentanyl Related CoMpound E CII
- CBNumber:
- CB3506659
- Molecular Formula:
- C19H24N2
- Molecular Weight:
- 280.41
- MDL Number:
- MFCD00179023
- MOL File:
- 21409-26-7.mol
- MSDS File:
- SDS
| Melting point | 94-96°C |
|---|---|
| Boiling point | 172-176 °C(Press: 0.15 Torr) |
| Density | 1.075±0.06 g/cm3(Predicted) |
| Flash point | 9°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility |
Acetonitrile: Soluble DMSO: Soluble Methanol: Soluble |
| pka | 9.03±0.10(Predicted) |
| form | Off-white solid. |
| Major Application | pharmaceutical |
| InChI | 1S/C19H24N2/c1-3-7-17(8-4-1)11-14-21-15-12-19(13-16-21)20-18-9-5-2-6-10-18/h1-10,19-20H,11-16H2 |
| InChIKey | ZCMDXDQUYIWEKB-UHFFFAOYSA-N |
| SMILES | N2(CCC(CC2)Nc3ccccc3)CCc1ccccc1 |
| FDA UNII | Q88EHD0U8G |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P280-P301+P330+P331+P310-P302+P352+P310-P304+P340+P310 | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-37/39-46 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 1 Dermal Acute Tox. 1 Inhalation Acute Tox. 1 Oral |
|||||||||
| DEA Controlled Substances | CSCN: 8333 CSA SCH: Schedule II NARC: No |
|||||||||
| NFPA 704 |
|
4-Aminophenyl-1-phenethylpiperidine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR8974 | Fentanyl Related Compound E certified reference material, pharmaceutical secondary standard | 21409-26-7 | 20mg | $457 | 2026-04-30 | Buy |
| Sigma-Aldrich | A-139 | 4-ANPP solution 100?μg/mL in methanol, certified reference material, ampule of 0.5?mL, Cerilliant? | 21409-26-7 | 0.5ml | $136 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1269957 | Fentanyl Related Compound E United States Pharmacopeia (USP) Reference Standard | 21409-26-7 | 10mg | $1340 | 2026-04-30 | Buy |
| Cayman Chemical | 39715 | 4-ANPP ≥95% | 21409-26-7 | 25mg | $641 | 2026-04-30 | Buy |
| Cayman Chemical | 39715 | 4-ANPP ≥95% | 21409-26-7 | 50mg | $961 | 2026-04-30 | Buy |
4-Aminophenyl-1-phenethylpiperidine Chemical Properties, Uses, Production
Description
4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. It has also been found as an impurity in illicit fentanyl preparations. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Description
4-ANPP (CRM) (Item No. 22700) is a certified reference material that is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl (Item Nos. 22659 | 14719 | ISO60197) from N-phenethyl-4-piperidone (NPP; ). As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl (Item Nos. ISO00128 | ISO60128), butyryl fentanyl (Item Nos. 14728 | 19734), furanyl fentanyl (Item Nos. 18705 | 19633), acrylfentanyl , and fentanyl. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical Properties
Pale Yellow Solid
Uses
A 3H-Fentanyl (F274990) metabolite
References
[1] R B LABROO. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.[J]. Drug Metabolism and Disposition, 1997, 25 9: 1072-1080.
[2] A. B. MELENT’EV O. N D S S Kataev. Identification and analytical properties of acetyl fentanyl metabolites[J]. Journal of Analytical Chemistry, 2015, 70 2: 240-248. DOI: 10.1134/s1061934815020124
[3] ANDREA E. STEUER. Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS)[J]. Drug Testing and Analysis, 2016, 9 7: 1085-1092. DOI: 10.1002/dta.2111
[4] MüLLER M, WUBBOLTS M. Biotransformation Methods for Preparing Chiral Drugs and Drug Intermediates[C]. 2006: 0. DOI: 10.1002/9783527609437.ch4
[5] IRA S. LURIE . Profiling of illicit fentanyl using UHPLC–MS/MS[J]. Forensic science international, 2012, 220 1: Pages 191-196. DOI: 10.1016/j.forsciint.2012.02.024
[6] SHIMPEI WATANABE. In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.[J]. AAPS Journal, 2017, 19 4: 1102-1122. DOI: 10.1208/s12248-017-0070-z
4-Aminophenyl-1-phenethylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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