Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
- CAS No.
- 188781-08-0
- Chemical Name:
- Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
- Synonyms
- 2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine;Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate;Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%;2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester;2-chloro-4-methyl-5-Pyrimidinecarboxylic acid ethyl ester (9CI ACI);5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester (9CI, ACI);2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine
- CBNumber:
- CB3523447
- Molecular Formula:
- C8H9ClN2O2
- Molecular Weight:
- 200.62
- MDL Number:
- MFCD03425963
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 296121 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Asreported | 188781-08-0 | 50mg | $359 | 2026-06-03 | Buy |
| Usbiological | 296121 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Asreported | 188781-08-0 | 100mg | $496 | 2026-06-03 | Buy |
| Usbiological | 296121 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Asreported | 188781-08-0 | 250mg | $612 | 2026-06-03 | Buy |
| Usbiological | 296121 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Asreported | 188781-08-0 | 500mg | $907 | 2026-06-03 | Buy |
| Usbiological | 296121 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Asreported | 188781-08-0 | 1g | $1247 | 2026-06-03 | Buy |
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
It is an active pharmaceutical intermediates.
Synthesis
6214-64-8
188781-08-0
The general procedure for the synthesis of ethyl 4-methyl-2-chloropyrimidine-5-carboxylate from ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate was as follows: ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate (10 mmol) was dissolved in phosphorochloride (10 mL), and heated and refluxed for 30 min. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. Subsequently, residual phosphorous trichloride was removed by azeotropic distillation with dried benzene. Finally, the crude product was purified by column chromatography to afford pure ethyl 4-methyl-2-chloropyrimidine-5-carboxylate.
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2290 - 2294
[2] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 70
[3] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 314 - 323
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 726 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-17 | Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
188781-08-0
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
188781-08-0
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
188781-08-0
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
188781-08-0
- $1.00
- 98%
- Career Henan Chemical Co
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