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ChemicalBook >> CAS DataBase List >>2-Chloro-4-methylpyrimidine

2-Chloro-4-methylpyrimidine

2-Chloro-4-methylpyrimidine Structure
2-Chloro-4-methylpyrimidine structure
CAS No.
13036-57-2
Chemical Name:
2-Chloro-4-methylpyrimidine
Synonyms
chloro-4-MethylpyriMidine;2-Chloro-6-methylpyrimidine;2-CHLORO-4-METHYLPYRIMIDINE;2-Chloro-4-methyl-1,3-diazine;Pyrimidine, 2-chloro-4-methyl-;2-CHLORO-4-METHYLPYRIMIDINE 98%;2-Chloro-4-methylpyrimidine >2-Chloro-4-methylpyrimidine ISO 9001：2015 REACH;Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI)
CBNumber:
CB6434803
Molecular Formula:
C5H5ClN2
Molecular Weight:
128.56
MDL Number:
MFCD00054434
MOL File:
13036-57-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-31 08:25:00
Request For Quotation

2-Chloro-4-methylpyrimidine Properties

Melting point 35-36°C
Boiling point 94°C/17mmHg(lit.)
Density 1.234±0.06 g/cm3(Predicted)
Flash point 98℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform
form Solid
pka -0.93±0.20(Predicted)
color Pale Yellow to Beige
Sensitive Moisture Sensitive
Stability Toxic
InChI InChI=1S/C5H5ClN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3
InChIKey BHAKRVSCGILCEW-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(C)=N1
CAS DataBase Reference 13036-57-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
Hazard Codes  Xi,Xn
Risk Statements  22-41-37/38
Safety Statements  26-39
WGK Germany  3
TSCA  N
HazardClass  IRRITANT
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

2-Chloro-4-methylpyrimidine price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 741116 2-Chloro-4-methylpyrimidine 97% 13036-57-2 1g $69 2023-01-07 Buy
TCI Chemical C2631 2-Chloro-4-methylpyrimidine >98.0%(GC) 13036-57-2 5g $34 2026-04-30 Buy
TCI Chemical C2631 2-Chloro-4-methylpyrimidine >98.0%(GC) 13036-57-2 25g $124 2026-04-30 Buy
Usbiological C5028-62 2-Chloro-4-methylpyrimidine 1g $389 2026-06-03 Buy
Usbiological 267528 2-Chloro-4-methylpyrimidine Asreported 13036-57-2 10g $333 2026-06-03 Buy
Product number Packaging Price Buy
741116 1g $69 Buy
C2631 5g $34 Buy
C2631 25g $124 Buy
C5028-62 1g $389 Buy
267528 10g $333 Buy

2-Chloro-4-methylpyrimidine Chemical Properties, Uses, Production

Chemical Properties

Pale Yellow Solid

Uses

2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.

Application

2-chloro-4-methylpyrimidine could be used to synthesis 4-Methyl-2-vinylpyrimidine which is a intermediate of pyrimidinyl trans-cyclopropane carboxylic acid (rac-1)[1].
2-Chloro-4-methylpyrimidine

Synthesis

2,4-Dichloro-6-methylpyrimidine

5424-21-5

2-Chloro-4-methylpyrimidine

13036-57-2

Step A: Synthesis of 2-chloro-4-methylpyrimidine To a vigorously stirred slurry containing 50.0 g (0.31 mol) of 2,6-dichloro-4-methylpyrimidine, 250 mL of ethanol (EtOH), and 250 mL of water, 41 g (0.63 mol) of zinc powder and 0.78 g (3.08 mmol) of iodine were sequentially added. The reaction mixture was heated to reflux at 70°C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to remove ethanol and subsequently extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to remove solvent. The residue was purified by silica gel column chromatography using a hexane/DCM solvent mixture as eluent, resulting in 20.6 g (53% yield) of 2-chloro-4-methylpyrimidine as a white solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 400 MHz) δ 8.59 (d, 1H, J=4.9 Hz), 7.44 (d, 1H, J=4.9 Hz), and 3.29 (s, 3H), and ESIMS: 129.11 (M+H+).

References

[1] M. Fray. “N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid.” Organic Process Research &Development 19 1 (2023).

2-Chloro-4-methylpyrimidine synthesis

5424-21-5
13036-57-2
Synthesis of 2-Chloro-4-methylpyrimidine from 2,4-Dichloro-6-methylpyrimidine

2-Chloro-4-methylpyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-Hydroxy-4-methylpyrimidine Sodium carbonate 2,4-Dichloropyrimidine 2,4-Dichloro-6-methylpyrimidine
2-Chloropyrimidine Methyllithium Methylmagnesium chloride Water ZINC

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Preparation Products

2-Chloro-4-(chloromethyl)pyrimidine 2(1H)-Pyrimidinone, 4-methyl-, hydrazone (9CI)

2-Chloro-4-methylpyrimidine Suppliers

Global Suppliers ( 399)
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 473 75
Changzhou Ucheml Medicine Co., Ltd. 0519-86058959 13775231161 sales@uchemi.cn China 301 50
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. 023-89130144 18523560356 zhyong1011@163.com China 297 58
Shandong Winner Biotechnology Co., Ltd. 15315319889 15315319889 wannaswsw@163.com China 407 58
Enki Biopharmaceuticals(Shanghai) Limited +86-21 5768 0965 +86-13916707528 yusu@enkibiopharma.com China 47 55
JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD 18668921571 liujnlz@126.com China 22 58
Hangzhou Yinghui Industrial Co.,Ltd +86-15355417531 +86-15355417531 2028755477@qq.com China 499 58
Jiangxi Hechun Pharmaceutical Technology Co., Ltd. 13033833208 3692193759@qq.com China 72 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Changzhou Ucheml Medicine Co., Ltd. 50
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. 58
Shandong Winner Biotechnology Co., Ltd. 58
Enki Biopharmaceuticals(Shanghai) Limited 55
JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD 58
Hangzhou Yinghui Industrial Co.,Ltd 58
Jiangxi Hechun Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Liaoning Tianhua Chemical Co., Ltd. 69

View Latest Price from 2-Chloro-4-methylpyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-methylpyrimidine pictures 2026-09-16 2-Chloro-4-methylpyrimidine
13036-57-2
 1kg 99.35% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-4-methylpyrimidine pictures 2026-09-03 2-Chloro-4-methylpyrimidine
13036-57-2
 99.9% 40-80kgs Zison Pharmaceutical (Shandong) Co., Ltd.
2-Chloro-4-methylpyrimidine pictures 2026-08-25 2-Chloro-4-methylpyrimidine
13036-57-2
 $50.00-500.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

2-Chloro-4-methylpyrimidine Spectrum

2-Chloro-4-methylpyrimidine(13036-57-2)1HNMR

13036-57-2 (2-Chloro-4-methylpyrimidine) Related Search:

4-Methylpyridine 2,5-Dimethylpyridine 2,6-Lutidine 2-Chloro-4-nitropyridine Chromium picolinate
2,4,6-Collidine 2-chloro-6-trichloromethylpyridine 2-(Chloromethyl)pyridine 2-Chloro-4-methyl-thiazole CRIMIDINE
2-Chloro-4,6-dimethylpyrimidine Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 2,4-Dichloro-6-methyl-5-nitropyrimidine 2-Chloro-4-(trifluoromethyl)pyrimidine 2,4-Dichloro-6-methylpyrimidine
Methyl 2-chloro-6-methylpyrimidine-4-carboxylate 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride Difluorochloromethane

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2-CHLORO-4-METHYLPYRIMIDINE Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI) 2-CHLORO-4-METHYLPYRIMIDINE 98% 2-Chloro-6-methylpyrimidine 2-Chloro-4-methyl-1,3-diazine 2-Chloro-4-methylpyrimidine > Pyrimidine, 2-chloro-4-methyl- 2-Chloro-4-methylpyrimidine ISO 9001：2015 REACH chloro-4-MethylpyriMidine 13036-57-2 130036-57-2 Aromatics Heterocycles Miscellaneous Reagents pyridine Chlorinated heterocyclic series Building Blocks C4 to C5 Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis Bases & Related Reagents Nucleotides Halides Pyrazines, Pyrimidines & Pyridazines Boronic Acid pharmacetical Nucleotides and Nucleosides PYRIMIDINE Heterocycle-Pyrimidine series Pyrimidines