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2-Chloro-4-methylpyrimidine

2-Chloro-4-methylpyrimidine structure

CAS No.: 13036-57-2

Chemical Name:: 2-Chloro-4-methylpyrimidine

Synonyms: chloro-4-MethylpyriMidine;2-CHLORO-4-METHYLPYRIMIDINE;2-Chloro-6-methylpyrimidine;2-Chloro-4-methyl-1,3-diazine;Pyrimidine, 2-chloro-4-methyl-;2-CHLORO-4-METHYLPYRIMIDINE 98%;2-Chloro-4-methylpyrimidine >2-Chloro-4-methylpyrimidine ISO 9001：2015 REACH;Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI)

CBNumber:: CB6434803

Molecular Formula:: C5H5ClN2

Molecular Weight:: 128.56

MDL Number:: MFCD00054434

MOL File:: 13036-57-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:52

Product description	Number	Pack Size	Price
2-Chloro-4-methylpyrimidine 97%	741116	1g	$69
2-Chloro-4-methylpyrimidine >98.0%(GC)	C2631	5g	$34
2-Chloro-4-methylpyrimidine >98.0%(GC)	C2631	25g	$124
2-Chloro-4-methylpyrimidine	C369530	25g	$195
2-Chloro-4-methylpyrimidine	C5028-62	1g	$389
More product size

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2-Chloro-4-methylpyrimidine Properties

Melting point	35-36°C
Boiling point	94°C/17mmHg(lit.)
Density	1.234±0.06 g/cm3(Predicted)
Flash point	98℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform
pka	-0.93±0.20(Predicted)
form	Solid
color	Pale Yellow to Beige
Sensitive	Moisture Sensitive
Stability	Toxic
InChI	InChI=1S/C5H5ClN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3
InChIKey	BHAKRVSCGILCEW-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC(C)=N1
CAS DataBase Reference	13036-57-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

Hazard Codes

Xi,Xn

Risk Statements

22-41-37/38

Safety Statements

26-39

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Chloro-4-methylpyrimidine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	741116	2-Chloro-4-methylpyrimidine 97%	13036-57-2	1g	$69	2023-01-07	Buy
TCI Chemical	C2631	2-Chloro-4-methylpyrimidine >98.0%(GC)	13036-57-2	5g	$34	2026-03-19	Buy
TCI Chemical	C2631	2-Chloro-4-methylpyrimidine >98.0%(GC)	13036-57-2	25g	$124	2026-03-19	Buy
TRC	C369530	2-Chloro-4-methylpyrimidine	13036-57-2	25g	$195	2021-12-16	Buy
Usbiological	C5028-62	2-Chloro-4-methylpyrimidine	13036-57-2	1g	$389	2021-12-16	Buy

Product number	Packaging	Price	Buy
741116	1g	$69	Buy
C2631	5g	$34	Buy
C2631	25g	$124	Buy
C369530	25g	$195	Buy
C5028-62	1g	$389	Buy

2-Chloro-4-methylpyrimidine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.

Application

2-chloro-4-methylpyrimidine could be used to synthesis 4-Methyl-2-vinylpyrimidine which is a intermediate of pyrimidinyl trans-cyclopropane carboxylic acid (rac-1)[1].

Synthesis

5424-21-5

13036-57-2

Step A: Synthesis of 2-chloro-4-methylpyrimidine To a vigorously stirred slurry containing 50.0 g (0.31 mol) of 2,6-dichloro-4-methylpyrimidine, 250 mL of ethanol (EtOH), and 250 mL of water, 41 g (0.63 mol) of zinc powder and 0.78 g (3.08 mmol) of iodine were sequentially added. The reaction mixture was heated to reflux at 70°C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to remove ethanol and subsequently extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to remove solvent. The residue was purified by silica gel column chromatography using a hexane/DCM solvent mixture as eluent, resulting in 20.6 g (53% yield) of 2-chloro-4-methylpyrimidine as a white solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 400 MHz) δ 8.59 (d, 1H, J=4.9 Hz), 7.44 (d, 1H, J=4.9 Hz), and 3.29 (s, 3H), and ESIMS: 129.11 (M+H+).

References

[1] M. Fray. “N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid.” Organic Process Research &Development 19 1 (2023).

2-Chloro-4-methylpyrimidine synthesis

Synthesis of 2-Chloro-4-methylpyrimidine from 2,4-Dichloro-6-methylpyrimidine

2-Chloro-4-methylpyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-HYDROXY-4-METHYLPYRIMIDINE Sodium carbonate 2,4-Dichloropyrimidine 2,4-Dichloro-6-methylpyrimidine

2-Chloropyrimidine Methyllithium Methylmagnesium chloride Water ZINC

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Preparation Products

2-Chloro-4-(chloromethyl)pyrimidine 2(1H)-Pyrimidinone, 4-methyl-, hydrazone (9CI)

2-Chloro-4-methylpyrimidine Suppliers

Global( 393)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	yusu@enkibiopharma.com	China	53	58
ANHUI CHICO CHEMICAL CO., LTD.	+8613057662806	kirsten@chicopharm.com	China	2396	58
Zison Pharmaceutical (Shandong) Co., Ltd.	+86-0086-531-88259693 +86-18660188356	tracy.li@zisonpharm.com	China	88	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5974	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
Enki Biopharmaceuticals (Shanghai) Limited	58
ANHUI CHICO CHEMICAL CO., LTD.	58
Zison Pharmaceutical (Shandong) Co., Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 2-Chloro-4-methylpyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-29	2-Chloro-4-methylpyrimidine 13036-57-2	US $0.00-0.00 / kg	1kg	99.35%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-15	2-Chloro-4-methylpyrimidine 13036-57-2	US $0.00 / kg	0.1kg	99.9%	40-80kgs	Zison Pharmaceutical (Shandong) Co., Ltd.
2025-11-18	2-Chloro-4-methylpyrimidine 13036-57-2	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited

2-Chloro-4-methylpyrimidine
13036-57-2
US $0.00-0.00 / kg
99.35%
WUHAN FORTUNA CHEMICAL CO., LTD

2-Chloro-4-methylpyrimidine
13036-57-2
US $0.00 / kg
99.9%
Zison Pharmaceutical (Shandong) Co., Ltd.

2-Chloro-4-methylpyrimidine
13036-57-2
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Chloro-4-methylpyrimidine Spectrum

2-Chloro-4-methylpyrimidine(13036-57-2)¹HNMR

13036-57-2(2-Chloro-4-methylpyrimidine)Related Search:

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2,4-Dichloro-6-methyl-5-nitropyrimidine 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONYL CHLORIDE 2-Chloro-4-(trifluoromethyl)pyrimidine CRIMIDINE 2-Chloro-4,6-dimethylpyrimidine

2,4-Dichloro-6-methylpyrimidine METHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE,Methyl 2-chloro-4-methylpyrimidine-6-carboxylate, HPLC +97% Difluorochloromethane

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chloro-4-MethylpyriMidine 2-CHLORO-4-METHYLPYRIMIDINE Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI) 2-CHLORO-4-METHYLPYRIMIDINE 98% 2-Chloro-6-methylpyrimidine 2-Chloro-4-methyl-1,3-diazine 2-Chloro-4-methylpyrimidine > Pyrimidine, 2-chloro-4-methyl- 2-Chloro-4-methylpyrimidine ISO 9001：2015 REACH 13036-57-2 130036-57-2 Aromatics Heterocycles Miscellaneous Reagents pyridine Chlorinated heterocyclic series Building Blocks C4 to C5 Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis Bases & Related Reagents Nucleotides Halides Pyrazines, Pyrimidines & Pyridazines Boronic Acid pharmacetical Nucleotides and Nucleosides PYRIMIDINE Heterocycle-Pyrimidine series Pyrimidines