Z-YVAD-CMK (trifluoroacetate salt)
- CAS No.
- Chemical Name:
- Z-YVAD-CMK (trifluoroacetate salt)
- Synonyms
- Z-YVAD-CMK (trifluoroacetate salt)
- CBNumber:
- CB35540856
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Z-YVAD-CMK (trifluoroacetate salt) price More Price(2)
Z-YVAD-CMK (trifluoroacetate salt) Chemical Properties, Uses, Production
Description
Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3.1,2 It reduces IL-1β and IL-18 secretion in isolated mouse peritoneal macrophages stimulated by cholesterol-treated recombinant pneumolysin protein (rPLY) when used at a concentration of 30 µM.1 Z-YVAD-CMK reduces caspase-3 activation by the EGF-like domain of tenascin-C in detached human smooth muscle cells (hSMCs) in vitro.2 It also decreases cell death induced by the EGF-like domain of tenascin-C by 50% when used at a concentration of 100 µM in hSMCs and completely inhibits cell death at concentrations ranging from 200 to 400 µM.WARNING This product is not for human or veterinary use.
References
[1] SHEREEN SHOMA. Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.[J]. Infection and Immunity, 2008: 1547-1557. DOI: 10.1128/iai.01269-07
[2] KURT WALLNER. EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2004, 24 8: 1416-1421. DOI: 10.1161/01.atv.0000134299.89599.53
Z-YVAD-CMK (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Z-YVAD-CMK (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
