GNE-8324
- CAS No.
- 1698901-76-6
- Chemical Name:
- GNE-8324
- Synonyms
- GNE8324;GNE 8324;GNE-8324;GNE-8324; GNE 8324; GNE8324;4H,6H-Cyclopenta[4,5]thiazolo[3,2-a]pyrimidin-4-one, 2-[[ethyl(4-fluorophenyl)amino]methyl]-7,8-dihydro-;10-{[ethyl(4-fluorophenyl)amino]methyl}-7-thia-1,9-diazatricyclo[6.4.0.02,?]dodeca-2(6),8,10-trien-12-one
- CBNumber:
- CB35582377
- Molecular Formula:
- C18H18FN3OS
- Molecular Weight:
- 343.42
- MDL Number:
- MFCD33029243
- MOL File:
- 1698901-76-6.mol
GNE-8324 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611954 | GNE-8324 >98% | 1698901-76-6 | 10mg | $912.9 | 2021-12-16 | Buy |
| ChemScene | CS-0028635 | GNE-8324 | 1698901-76-6 | 25mg | $950 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611954 | GNE-8324 >98% | 1698901-76-6 | 25mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611954 | GNE-8324 >98% | 1698901-76-6 | 100mg | $2839 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611955 | GNE-8324 >98% | 1698901-76-6 | 10mg | $3282.7 | 2021-12-16 | Buy |
GNE-8324 Chemical Properties,Uses,Production
Description
GNE-8324 is a potent and selective NMDA receptor PAM.
Uses
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons[1].
in vitro
This study showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity in vitro and in vivo._x000D_ _x000D_ Reference: Front Pharmacol. 2022 Jan 4;12:796179. https://pubmed.ncbi.nlm.nih.gov/35058780/
target
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.
References
[1] Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000. DOI:10.1038/s41467-018-06512-7
GNE-8324 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-8324 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7996 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 10026 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
