| Company Name: |
InvivoChem |
| Tel: |
+1-708-310-1919 +1-13798911105 |
| Email: |
sales@invivochem.cn |
GNE-8324 manufacturers
- GNE-8324
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- $737.00
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2026-07-27
- CAS:1698901-76-6
- Purity: 99.40%
- Supply Ability: 10g
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| | GNE-8324 Basic information |
| Product Name: | GNE-8324 | | Synonyms: | GNE 8324;GNE8324;GNE-8324;GNE-8324; GNE 8324; GNE8324;4H,6H-Cyclopenta[4,5]thiazolo[3,2-a]pyrimidin-4-one, 2-[[ethyl(4-fluorophenyl)amino]methyl]-7,8-dihydro-;10-{[ethyl(4-fluorophenyl)amino]methyl}-7-thia-1,9-diazatricyclo[6.4.0.02,?]dodeca-2(6),8,10-trien-12-one | | CAS: | 1698901-76-6 | | MF: | C18H18FN3OS | | MW: | 343.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1698901-76-6.mol |  |
| | GNE-8324 Chemical Properties |
| form | Solid | | color | White to off-white |
| | GNE-8324 Usage And Synthesis |
| Description | GNE-8324 is a potent and selective NMDA receptor PAM. | | Uses | GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons[1]. | | in vitro | This study showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity in vitro and in vivo._x000D_
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Reference: Front Pharmacol. 2022 Jan 4;12:796179. https://pubmed.ncbi.nlm.nih.gov/35058780/ | | target | GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons. | | References | [1] Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000. DOI:10.1038/s41467-018-06512-7 |
| | GNE-8324 Preparation Products And Raw materials |
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