des-His1-[Glu9]-Glucagon (1-29)
- CAS No.
- 110121-11-4
- Chemical Name:
- des-His1-[Glu9]-Glucagon (1-29)
- Synonyms
- des-His1-[Glu9]-Glucagon (1-29)
- CBNumber:
- CB35590028
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- TDS File:
- TDS
des-His1-[Glu9]-Glucagon (1-29) Chemical Properties, Uses, Production
Uses
[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].
in vivo
[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1].
| Animal Model: | New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1] |
| Dosage: | 3.6-4.0 μg/kg |
| Administration: | i.v.; single dosage |
| Result: | Suppressed hyperglycemic response of glucagon. |
| Animal Model: | Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1] |
| Dosage: | 1 mg/kg |
| Administration: | Intravenously administration through the tail vein; single dosage |
| Result: | Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min. |
References
[1] Unson CG, et al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov-Dec;10(6):1171-7. DOI:10.1016/0196-9781(89)90010-7
des-His1-[Glu9]-Glucagon (1-29) Preparation Products And Raw materials
Raw materials
Preparation Products
des-His1-[Glu9]-Glucagon (1-29) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2436 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
| Fuan Bio | 15002819872 | 2845971812@qq.com | China | 2103 | 58 |
