CYP17A1 antibody
- CAS No.
- Chemical Name:
- CYP17A1 antibody
- Synonyms
- CYP17A1 antibody;Rabbit Polyclonal CYP17A1 Antibody
- CBNumber:
- CB35620925
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
CYP17A1 antibody price
CYP17A1 antibody Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human
Background
CYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases. In humans, CYP17A1 expression is abundantly expressed in the adrenal cortex, where it plays a central role in the androgen synthesis pathway. CYP17A1 is the primary target of abiraterone, a synthetic steroid used in the treatment of castration-resistant prostate cancer. Abiraterone is converted to the more active form D4A, which antagonizes androgen receptor signaling by inhibiting CYP17A1 and other steroidogenic enzymes. This suppresses the synthesis of 5α-dihydrotestosterone, which is a driver of castration-resistant prostate cancer cell growth.
References
[1] Missaghian, E. et al. (2009) J Endocrinol 202, 99-109.
[2] Tee, M.K. and Miller, W.L. (2013) J Biol Chem 288, 23903-13.
[3] Li, Z. et al. (2015) Nature 523, 347-51.
[4] Thoma, C. (2015) Nat Rev Urol 12, 363.
CYP17A1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
CYP17A1 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
