Tubulysin E
- CAS No.
- 309935-58-8
- Chemical Name:
- Tubulysin E
- Synonyms
- Tubulysin E;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-α-methyl-, (αS,γR)-
- CBNumber:
- CB35821203
- Molecular Formula:
- C42H63N5O9S
- Molecular Weight:
- 814.05
- MDL Number:
- MFCD32197331
- MOL File:
- 309935-58-8.mol
| Boiling point | 948.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.51±0.23(Predicted) |
| FDA UNII | SXT0V84S0H |
Tubulysin E Chemical Properties, Uses, Production
Uses
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].
Definition
ChEBI: Tubulysin E is a butyrate ester.
References
[1] Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. DOI:10.1002/anie.200906828
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041
Tubulysin E Preparation Products And Raw materials
Raw materials
Preparation Products
Tubulysin E Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| SHAANXI?DIDEU?MEDICHEM CO.LTD | 17691182729 17392216275 | 1073@dideu.com | China | 9993 | 58 |
| Shanghai Joyheal Pharmaceutical Co., Ltd. | 18168068961 | info@Yucarepharma.com | China | 108 | 58 |
