1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
- CAS No.
- 2270879-17-7
- Chemical Name:
- 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
- Synonyms
- NVP-RXI570;BRM/BRG1 ATP Inhibitor-1 (BRM014);BRM/BRG1 ATP Inhibitor-1, 10 mM in DMSO;1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea;3-[3-(difluoromethyl)-1,2-thiazol-5-yl]-1-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea;Urea, N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-;BRM/BRG1 ATP Inhibitor 1,Epigenetic Reader Domain,ATPase inhibitor,BRM/BRG-1 ATP Inhibitor-1,anticancer,BRM/BRG1 ATP Inhibitor-1,(BRG1)/SMARCA4,dual inhibitor,Inhibitor,inhibit,(BRM)/SMARCA2,BRM/BRG1 ATP Inhibitor1
- CBNumber:
- CB35832995
- Molecular Formula:
- C11H9F3N4O2S
- Molecular Weight:
- 318.27
- MDL Number:
- MOL File:
- 2270879-17-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 333.4±42.0 °C(Predicted) |
|---|---|
| Density | 1.659±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 11.76±0.70(Predicted) |
| color | White to off-white |
| InChI | 1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20) |
| InChIKey | CKYCAIAVJIFWPE-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3545 | NVP-RXI570 ≥98% (HPLC) | 2270879-17-7 | 5MG | $109 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3545 | NVP-RXI570 ≥98% (HPLC) | 2270879-17-7 | 25MG | $439 | 2026-04-30 | Buy |
| Cayman Chemical | 36138 | BRM/BRG1 ATP Inhibitor 1 ≥98% | 2270879-17-7 | 500μg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 36138 | BRM/BRG1 ATP Inhibitor 1 ≥98% | 2270879-17-7 | 1mg | $164 | 2026-04-30 | Buy |
| Cayman Chemical | 36138 | BRM/BRG1 ATP Inhibitor 1 ≥98% | 2270879-17-7 | 5mg | $382 | 2026-04-30 | Buy |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Chemical Properties, Uses, Production
Uses
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 μM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity[1].
Biological Activity
NVP-RXI570 is an orally active, potent, and selective allosteric dual inhibitor of BRM ((SMARCA2) and BRG1 (SMARCA4) th at th at downregulates BRM-dependent gene expression. NVP-RXI570 exhibits antiproliferative activity in a BRG1 mutant-lung-tumor xenograft model.
in vivo
BRM/BRG1 ATP Inhibitor-1 (compound 14) (oral administration, 7.5 or 20 mg/kg, everyday, 3 weeks) can inhibit tumor growth and inhibit KRT80 expression in a dose-dependent manner[1].
| Animal Model: | Female athymic nude mice with RERF-LC-AI tumor xenografts[1] |
| Dosage: | 7.5 mg/kg, 20 mg/kg |
| Administration: | Oral administration; everyday; 3 weeks |
| Result: | Inhibited tumor growth by 21% and 55% at doses of 7.5 mg/kg and 20 mg/kg, respectively. Inhibited KRT80 expression by up to 90% at 20 mg/kg for 7 hours after administration. |
References
[1] Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172 DOI:10.1021/acs.jmedchem.8b01318
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| Shanghai ruichang pharmaceutical technology co., LTD | 18621054990 | maychemicals@sina.com | China | 673 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
View Latest Price from 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-22 | 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
2270879-17-7
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-14 | BRM/BRG1 ATP Inhibitor-1
2270879-17-7
|
$179.00-683.00 | 99.62% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-14 | BRM/BRG1 ATP Inhibitor-1
2270879-17-7
|
$179.00-683.00 | 99.62% | 10g | TargetMol Chemicals Inc. |
-
- 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
2270879-17-7
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- BRM/BRG1 ATP Inhibitor-1
2270879-17-7
- $179.00-683.00
- 99.62%
- TargetMol Chemicals Inc.
-
- BRM/BRG1 ATP Inhibitor-1
2270879-17-7
- $179.00-683.00
- 99.62%
- TargetMol Chemicals Inc.
