UK-101
- CAS No.
- 1000313-40-5
- Chemical Name:
- UK-101
- Synonyms
- UK-101;UK101,UK 101;Heptanamide, N-[(1S)-2-[[(1S)-1-[[(2S)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxiranyl]carbonyl]-3-methylbutyl]amino]-1-methyl-2-oxoethyl]-
- CBNumber:
- CB35867267
- Molecular Formula:
- C25H48N2O5Si
- Molecular Weight:
- 484.74
- MDL Number:
- MFCD34469255
- MOL File:
- 1000313-40-5.mol
- MSDS File:
- SDS
UK-101 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066567 | UK-101 99.58% | 1000313-40-5 | 1mg | $314 | 2026-06-04 | Buy |
| ChemScene | CS-0066567 | UK-101 99.58% | 1000313-40-5 | 5mg | $585 | 2026-06-04 | Buy |
| ChemScene | CS-0066567 | UK-101 99.58% | 1000313-40-5 | 10mg | $942 | 2026-06-04 | Buy |
| ChemScene | CS-0066567 | UK-101 99.58% | 1000313-40-5 | 25mg | $1896 | 2026-06-04 | Buy |
| ChemScene | CS-0066567 | UK-101 99.58% | 1000313-40-5 | 50mg | $3087 | 2026-06-04 | Buy |
UK-101 Chemical Properties, Uses, Production
Description
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor. UK-101 induces cell apoptosis and can be used for the study of prostate cancer.
Uses
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC50 value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC50=15 μM) and β5 subunit (IC50=1 μM), respectivey[1]. UK-101 induces cell apoptosis and can be used for the study of prostate cancer[2].
in vivo
UK-101 (intraperitoneal injection; 1-3 mg/kg; twice a week; 3 weeks) decreases tumor volume as a dose-dependent manner, it significantly decreases tumor volume at a dose of 3 mg/kg. Additionally, UK-101-treated mice is suffering less systemic toxicity and the weights of mice treated with UK-101 remains steady over the 3-week treatment period[2].
| Animal Model: | Subcutaneously implanted PC-3 cells in 6-week-old male BALB/c athymic nude mice[2] |
| Dosage: | 1 mg/kg; 3 mg/kg |
| Administration: | Intraperitoneal injection; twice a week; 3 weeks |
| Result: | Inhibited tumour growth in the prostate cancer mouse xenograft model. |
References
[1] de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem.2014Jul 24;57(14):6197-209. DOI:10.1021/jm500716s
[2] Wehenkel M, et al. A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice. Br J Cancer.2012Jun 26;107(1):53-62. DOI:10.1038/bjc.2012.243
UK-101 Preparation Products And Raw materials
Raw materials
Preparation Products
UK-101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
