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MDR652

MDR652 Structure
MDR652 structure
CAS No.
1933528-96-1
Chemical Name:
MDR652
Synonyms
MDR652;MDR-652, 10 mM in DMSO;1-((2-(tert-Butyl)-4-(3-chlorophenyl)thiazol-5-yl)methyl)-3-(3-fluoro-4-(hydroxymethyl)phenyl)urea;Urea, N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]-;Inhibitor,Transient receptor potential channels,neuropathic,MDR-652,analgesic,TRP Channel,TRPV1,activity,pain,hTRPV1,MDR 652,inhibit,ligand,MDR652
CBNumber:
CB36127944
Molecular Formula:
C22H23ClFN3O2S
Molecular Weight:
447.95
MDL Number:
MOL File:
1933528-96-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:48:43
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MDR652 Properties

Boiling point 600.1±55.0 °C(Predicted)
Density 1.330±0.06 g/cm3(Predicted)
pka 12.25±0.46(Predicted)
form Solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338

MDR652 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth ICD52896 MDR-652 1933528-96-1 25mg $1112.25 2026-06-04 Buy
Biosynth ICD52896 MDR-652 1933528-96-1 50mg $1548 2026-06-04 Buy
Biosynth ICD52896 MDR-652 1933528-96-1 100mg $2476 2026-06-04 Buy
ChemScene CS-0128723 MDR-652 98.08% 1933528-96-1 5mg $184 2026-06-04 Buy
ChemScene CS-0128723 MDR-652 98.08% 1933528-96-1 10mg $271 2026-06-04 Buy
Product number Packaging Price Buy
ICD52896 25mg $1112.25 Buy
ICD52896 50mg $1548 Buy
ICD52896 100mg $2476 Buy
CS-0128723 5mg $184 Buy
CS-0128723 10mg $271 Buy

MDR652 Chemical Properties, Uses, Production

Uses

MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity[1].

in vivo

MDR-652 (0.5 and 5 mg/kg) displays a dose-dependent decrease of body temperature, supporting that MDR-652 displays TRPV1 agonism in the intact animal[1].
MDR-652 (5-10 mg/kg; i.p. and s.c.) blocks the neuropathic pain completely, indicating 100% maximum possible effect (MPE) [1].
MDR-652 has a promising topical pharmacokinetic profile[1].
MDR-652 has no significant toxicity. In a single-dose toxicity study, the LD50 of MDR-652 is higher than 200 and 2000 mg/kg in i.p. and p.o. administration, respectively[1].

Animal Model:ICR mouse[1]
Dosage:0.5 and 5 mg/kg
Administration:Administered intraperitoneally; 7 hours
Result:Decreased body temperature in a dose-dependent manner.
Animal Model:Rats with spinal nerve ligation (SNL) model[1]
Dosage:1, 2, 5, and 10 mg/kg
Administration:Administered intraperitoneally and subcutaneously; 24 hours
Result:The i.p. administration exhibited an excellent and dose dependent analgesic profile with an ED50 of 0.5-2 mg/kg.
The subcutaneous injection (sc) also displayed an excellent analgesic outcome with maximum effect at 30 min after administration.

IC 50

hTRPV1: 11.4 nM (Ki); rTRPV1: 23.8 nM (Ki); hTRPV1: 5.05 nM (EC50); rTRPV1: 93 nM (EC50)

References

[1] Jihyae Ann, et al. Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. J Med Chem. 2020 Jan 9;63(1):418-424. DOI:10.1021/acs.jmedchem.9b01046

MDR652 Preparation Products And Raw materials

Raw materials

Preparation Products

MDR652 Suppliers

Global Suppliers ( 44)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Fujian boshi pharmaceutical technology co. LTD 0595-22008920; 18120708884 393612455@qq.com China 257 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
BOC Sciences 65
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Fujian boshi pharmaceutical technology co. LTD 58
TargetMol Chemicals Inc. 58
InvivoChem 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Latest Price from MDR652 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MDR-652 pictures 2026-05-11 MDR-652
1933528-96-1
 $58.00-139.00 99.96% 10g TargetMol Chemicals Inc.
  • MDR-652 pictures
  • MDR-652
    1933528-96-1
  • $58.00-139.00
  • 99.96%
  • TargetMol Chemicals Inc.

MDR652 Spectrum

MDR652(1933528-96-1)1HNMR

1933528-96-1 (MDR652) Related Search:

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MDR652 Urea, N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]- 1-((2-(tert-Butyl)-4-(3-chlorophenyl)thiazol-5-yl)methyl)-3-(3-fluoro-4-(hydroxymethyl)phenyl)urea Inhibitor,Transient receptor potential channels,neuropathic,MDR-652,analgesic,TRP Channel,TRPV1,activity,pain,hTRPV1,MDR 652,inhibit,ligand,MDR652 MDR-652, 10 mM in DMSO 1933528-96-1 C22H23ClFN3O2S