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Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate Structure
Betamethasone 17,21-dipropionate structure
CAS No.
5593-20-4
Chemical Name:
Betamethasone 17,21-dipropionate
Synonyms
BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;Betamethasonediproprionate;Betamethasone dipropionate for system suitability;S 3440;Psorion;Maxivate
CBNumber:
CB3676725
Molecular Formula:
C28H37FO7
Molecular Weight:
504.6
MDL Number:
MFCD00072035
MOL File:
5593-20-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Betamethasone 17,21-dipropionate Properties

Melting point 178 °C
alpha D26 +65.7° (dioxane)
Boiling point 603.2±55.0 °C(Predicted)
Density 1.1481 (estimate)
refractive index 69 ° (C=1, Dioxane)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
pka 12.87±0.70(Predicted)
form Solid
color White to Pale Yellow
Merck 1180
Major Application pharmaceutical (small molecule)
InChIKey CIWBQSYVNNPZIQ-JCOVECCMSA-N
SMILES C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS DataBase Reference 5593-20-4(CAS DataBase Reference)
FDA UNII 826Y60901U
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H360FD-H373
Precautionary statements  P202-P260-P280-P308+P313-P405-P501
target organs Liver,Kidney,Endocrine system
Safety Statements  22-24/25
WGK Germany  2
RTECS  TU4058000
HS Code  29372290
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B
STOT RE 2
Toxicity LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82

Betamethasone 17,21-dipropionate price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001925 Betamethasone dipropionate for system suitability A European Pharmacopoeia (EP) Reference Standard 5593-20-4 10 mg $235 2026-04-30 Buy
Sigma-Aldrich Y0001416 Betamethasone dipropionate for peak identification European Pharmacopoeia (EP) Reference Standard 5593-20-4 10 mg $254 2026-04-30 Buy
Sigma-Aldrich B1152 Betamethasone 17,21-dipropionate ≥97.0% 5593-20-4 1g $304 2026-04-30 Buy
Sigma-Aldrich B1040000 Betamethasone dipropionate European Pharmacopoeia (EP) Reference Standard 5593-20-4 200 mg $254 2026-04-30 Buy
Sigma-Aldrich 1067704 Betamethasone dipropionate 5593-20-4 125mg $360 2026-04-30 Buy
Product number Packaging Price Buy
Y0001925 10 mg $235 Buy
Y0001416 10 mg $254 Buy
B1152 1g $304 Buy
B1040000 200 mg $254 Buy
1067704 125mg $360 Buy

Betamethasone 17,21-dipropionate Chemical Properties,Uses,Production

Chemical Properties

Betamethasone 17,21-dipropionate is Pale Yellow Foam

Originator

Betnovate,Glaxo,UK,1961

Uses

Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

Uses

antiviral

Uses

Cortico Steroids

Definition

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Manufacturing Process

A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'- ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid (20 ml), containing 2 drops of water, was allowed to stand at room temperature for 5 hours. Dilution of the mixture with water gave a white solid (457 mg) which, after being filtered off and dried, was recrystallized from acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α- propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg), MP 117°C (decomposition).

brand name

Alphatrex (Savage); Diprolene (Schering).

Therapeutic Function

Glucocorticoid

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.

Betamethasone 17,21-dipropionate synthesis

52092-14-5
5593-20-4
Synthesis of Betamethasone 17,21-dipropionate from (11β,16β)-9-BroMo-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione

Betamethasone 17,21-dipropionate Preparation Products And Raw materials

Raw materials

Acetic acid Propionyl chloride Triamcinolone

Preparation Products

9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate Betamethasone

Betamethasone 17,21-dipropionate Suppliers

Global( 442)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Wald Chemical Co., Ltd. 0531-88773586 13210588999 304264064@qq.com China 192 58
Shandong Yuhe Pharmaceutical Technology Co., LTD 15263077727 1436425847@qq.com China 296 58
Wuhan Zenuo Biopharmaceutical Technology Co., Ltd 027-87781970 15172508891 1505560767@qq.com China 132 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Jinan Wald Chemical Co., Ltd. 58
Shandong Yuhe Pharmaceutical Technology Co., LTD 58
Wuhan Zenuo Biopharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chembest Research Laboratories Limited 61
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Pure Chemistry Scientific Inc. 62

Related articles

View Lastest Price from Betamethasone 17,21-dipropionate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Betamethasone dipropionate pictures 2026-09-11 Betamethasone dipropionate
5593-20-4
 1kg 97%-103%; USP 100kg WUHAN FORTUNA CHEMICAL CO., LTD
Betamethasone Dipropionate pictures 2026-09-01 Betamethasone Dipropionate
5593-20-4
 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd
Betamethasone 17,21-dipropionate pictures 2026-08-21 Betamethasone 17,21-dipropionate
5593-20-4
 $1.00-10.00 2kg 99% 300tons Hebei Dangtong Import and export Co LTD

Betamethasone 17,21-dipropionate Spectrum

Betamethasone 17,21-dipropionate(5593-20-4)MSBetamethasone 17,21-dipropionate(5593-20-4)1HNMRBetamethasone 17,21-dipropionate(5593-20-4)13CNMRBetamethasone 17,21-dipropionate(5593-20-4)IR1Betamethasone 17,21-dipropionate(5593-20-4)IR2

5593-20-4(Betamethasone 17,21-dipropionate)Related Search:

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BetaMethasone dipropionat BETAMETHASONE 17,21-DI-PROPIONATE BETAMETHASONE 17-ALPHA,21-DIPROPIONATE 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17,21-DIPROPIONATE 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17,21-DIPROPIONATE 9--Fluoro-16--methyl-11,17,21-trihydroxy-1,4-pregnadiene-3,20-dione17,21-dipropionate BETANMETHASONE DIPROPIONATE BETAMETHASONEDIPROPIONATE,MICRONIZEDPOWDER,USP Diprophos Maxivate Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)- Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17,21-dipropionate (7CI, 8CI) Psorion Rinderon DP S 3440 Sch 11460 β-Methasone 17,21-dipropionate 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17,21-Dipropionate 17,21-Di(propionyloxy)-9-fluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate propionic acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-3-keto-10,13,16-trimethyl-17-(2-propionyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester Betamethasone 17,21-dipropionate,9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate Betamethasone Dipropionate (125 mg) Betamethasone 17,21- Betamethasone 17 propanoic acid [2-[(8R,9S,10R,11S,13S,14R,16S,17R)-8-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(1-oxopropoxy)-6,7,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester Betamethasone 17,21-dipropionate, ≥97.0% 9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate Betamethasone dipropionate for peak identification 17,21 betaMethasone dipropionate ester diproderm diprolene diprosis diprosone 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) Betanmethasone Dipronate Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-,(11Beta,16Beta)- (11-beta,16-beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate Betamethaasone Dipropionate Betamethasone 17,21-dipropionate(5593-20-4) Betamethasone dipropionate for peak identification CRS Betamethasone 17,21-Dipropionate > Betamethasone dipropionate CRS Diprolene AF Betamethasone dipropionate for system suitability A (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate Betamethasone dipropionate solution in Acetonitrile, 100μg/mL Anhydrous Beclometasone Dipropionate Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)- Betamethasone 17,21-dipropionate USP/EP/BP Betamethasone 17,21-dipropionat 99% High Purity Raw Powder Betamethason 17, 21-Dipropionate CAS 5593-20-4 Betamethasone dipropionate (B1040000)Q: What is Betamethasone dipropionate (B1040000) Q: What is the CAS Number of Betamethasone dipropionate (B1040000) Betamethasone dipropionate for peak identification (Y0001416) Betamethasone dipropionate for system suitability A (Y0001925) Betamethasone DipropionateQ: What is Betamethasone Dipropionate Q: What is the CAS Number of Betamethasone Dipropionate Q: What is the storage condition of Betamethasone Dipropionate Betamethasone Dipropionate (1067704)