Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N,N'-Bis-Boc-1-guanylpyrazole

N,N'-Bis-Boc-1-guanylpyrazole

N,N'-Bis-Boc-1-guanylpyrazole Structure
N,N'-Bis-Boc-1-guanylpyrazole structure
CAS No.
152120-54-2
Chemical Name:
N,N'-Bis-Boc-1-guanylpyrazole
Synonyms
N,N'-Di-Boc-1H-pyrazole-1-carboxamidine;tert-Butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate;tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate;tert-butyl N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate;tert-Butyl (NZ)-N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate;uanyL;Boc-Pyrazol;PYRAZOL(BOC)2;PYRAZOLE(BOC)2;N,N'-Bis-boc-1-g
CBNumber:
CB3679544
Molecular Formula:
C14H22N4O4
Molecular Weight:
310.35
MDL Number:
MFCD01075122
MOL File:
152120-54-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:08
Request For Quotation

N,N'-Bis-Boc-1-guanylpyrazole Properties

Melting point 86-90 °C(lit.)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slghtly), Methanol (Slightly)
form Solid
pka 6.92±0.46(Predicted)
color White to Off-White
Water Solubility Slightly soluble in water. Soluble in methanol, and chloroform.
Major Application peptide synthesis
InChI InChI=1S/C14H22N4O4/c1-13(2,3)21-11(19)16-10(18-9-7-8-15-18)17-12(20)22-14(4,5)6/h7-9H,1-6H3,(H,16,17,19,20)
InChIKey QFNFDHNZVTWZED-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)/N=C(/NC(OC(C)(C)C)=O)\N1C=CC=N1
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29331990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

N,N'-Bis-Boc-1-guanylpyrazole price More Price(104)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 434167 N,N′-Di-Boc-1H-pyrazole-1-carboxamidine 98% 152120-54-2 1g $63.9 2026-04-30 Buy
Sigma-Aldrich 434167 N,N′-Di-Boc-1H-pyrazole-1-carboxamidine 98% 152120-54-2 5g $94.8 2026-04-30 Buy
TCI Chemical B3619 N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine >98.0%(HPLC)(T) 152120-54-2 1g $32 2026-04-30 Buy
TCI Chemical B3619 N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine >98.0%(HPLC)(T) 152120-54-2 5g $88 2026-04-30 Buy
Usbiological 264289 N,N'-Bis-Boc-1-guanylpyrazol Asreported 152120-54-2 10g $386 2026-06-03 Buy
Product number Packaging Price Buy
434167 1g $63.9 Buy
434167 5g $94.8 Buy
B3619 1g $32 Buy
B3619 5g $88 Buy
264289 10g $386 Buy

N,N'-Bis-Boc-1-guanylpyrazole Chemical Properties, Uses, Production

Uses

N,N'-Di-Boc-1H-pyrazole-1-carboxamidine is used in the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin.N,N'-Di-Boc-1H-pyrazole-1-carboxamidine (also known as Bis-Boc-pyrazolocarboxamidine,Pyrazol(BOC)2) is typically used as a guanidinylating reagent in organic synthesis.

Chemical Properties

White solid

Uses

N,N'-Di-Boc-1H-pyrazole-1-carboxamidine is used in the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin.

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE

152120-61-1

N,N'-BIS-BOC-1-GUANYLPYRAZOLE

152120-54-2

Step F-2: Synthesis of tert-butyl (tert-butoxycarbonyliminopyrazol-1-yl - methyl) carbamate [Compound (H) N-Boc-1H-pyrazole-1-carboxamidine (50 g) prepared in step BI was dissolved in tetrahydrofuran (100 ml) and slowly added to a suspension of 60% sodium hydride (9.99 g) in tetrahydrofuran (100 ml) over a period of 1 h. The temperature of the reaction was maintained at -5°C to 0°C. After 30 minutes of continuous stirring at this temperature, a solution of tetrahydrofuran (100 ml) of di-tert-butyl dicarbonate (57.1 g) was added dropwise, keeping the temperature constant. Subsequently tetrahydrofuran (250 ml) was added and the reaction mixture was heated and stirred at reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, the reaction was quenched by the addition of acetic acid (20.4 ml) and concentrated under reduced pressure to about 150 ml. 5% aqueous sodium bicarbonate solution (500 ml) was added to the concentrate and extracted with ethyl acetate (500 ml). The organic layer was washed with water (150 ml) and concentrated under reduced pressure to about 75 ml. Hexane (200 ml) was added to the residue and inoculated with crystals, which were stirred under cooling in an ice bath for 40 min. The crystals were collected by filtration, washed with hexane (50 ml) and dried under reduced pressure to give N,N'-di-BOC-1H-1 -guanidinopyrazole (54.47 g, 73.8% yield). 1H NMR (CDCl3, 500MHz): δ 1.49 (9H, s), 1.55 (9H, s), 6.41 (1H, dd, J = 1.5, 2.7Hz), 7.62 (1H, dd, J = 0.7, 1.5Hz), 8.30 (1H, dd, J = 0.7, 2.7Hz), 8.93 (1H, brs). 13C NMR (CDCl3, 125MHz): δ 28.1, 28.2, 81.4, 83.4, 109.8, 129.0, 139.2, 142.8, 149.4, 157.4.

References

[1] Patent: WO2008/126943, 2008, A2. Location in patent: Page/Page column 79-80
[2] Synthesis, 2004, # 10, p. 1655 - 1663
[3] Tetrahedron Letters, 1993, vol. 34, # 21, p. 3389 - 3392
[4] Synthetic Communications, 1993, vol. 23, # 21, p. 3055 - 3060

N,N'-Bis-Boc-1-guanylpyrazole Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 1H-Pyrazole-1-carboxamidine hydrochloride N-(tert-Butoxycarbonyl)-1 H-pyrazole-1-carboxamidine Tetrahydrofuran Sodium hydride

Preparation Products

N,N'-Bis-Boc-1-guanylpyrazole Suppliers

Global Suppliers ( 297)
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Sphinx Scientific Laboratory(Tianjin) Co.,Ltd 022-66211289-818 13652044576 zhangxin@sphinxpharm.com China 136 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 15269103900 suchangzhou@shiningpharm.com China 384 58
Shandong Zircon Biotechnology Co., LTD 18105366931 18348401771 sdgs66880531@163.com China 196 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Sphinx Scientific Laboratory(Tianjin) Co.,Ltd 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 58
Shandong Zircon Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Beijing HwrkChemical Technology Co., Ltd 55

Related articles

View Latest Price from N,N'-Bis-Boc-1-guanylpyrazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N'-Bis-Boc-1-Guanylpyrazol pictures 2026-07-22 N,N'-Bis-Boc-1-Guanylpyrazol
152120-54-2
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
N,N'-BIS-BOC-1-GUANYLPYRAZOLE pictures 2025-04-04 N,N'-BIS-BOC-1-GUANYLPYRAZOLE
152120-54-2
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
N,N 2021-07-13 N,N"-BIS-BOC-1-GUANYLPYRAZOLE
152120-54-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

N,N'-Bis-Boc-1-guanylpyrazole Spectrum

N,N'-BIS-BOC-1-GUANYLPYRAZOLE(152120-54-2)1HNMRN,N'-BIS-BOC-1-GUANYLPYRAZOLE(152120-54-2)FT-IR

152120-54-2 (N,N'-Bis-Boc-1-guanylpyrazole) Related Search:

Aminoguanidine Sulfate tert-butyl ((1R,2R)-2-(hydroxymethyl)cyclopentyl)carbamate (1R,2R)-trans-N-Boc-2-Aminocyclohexanol tert-butyl ((1R,2S)-2-(aminomethyl)cyclopentyl)carbamate N,N'-Bis(tert-butoxycarbonyl)-N-(3-picolyl)-1H-pyrazole-1-carboxamidine
N,N'-Bis(tert-butoxycarbonyl)-N-tetrahydrofurfuryl-1H-pyrazole-1-carboxamidine N,N'-Bis(tert-butoxycarbonyl)-N-benzyl-1H-pyrazole-1-carboxamidine N,N'-Bis-Boc-1-guanylpyrazole

1of2

N,N''-Bis-(tert-butoxycarbonyl)-1-guanylpyrazole N,N'-DiBoc-1H-Pyrazole Guanidine N,N-Bis-(t-butyloxycarbonyl)-1-guanylpyrazole, N,N-Di-Boc-1H-pyrazole-1-carboxamidine N,N'-BIS-(T-BUTYL-OXYCARBONYL)-1-GUANYLPYRAZOLE N,N'-BIS-(TERT-BUTYLOXYCARBONYL)-1-GUANYLPYRAZOLE PYRAZOLE(BOC)2 PYRAZOL(BOC)2 N,N''-bis-Boc-1-guanylpyrazole [Pyrazole(Boc)] (NZ)-N-[[[(2-methylpropan-2-yl)oxy-oxometh N,N'-Di-Boc-1H-pyrazole-1-carboxamidine 98% N,N''-Bis-(tert-butoxycarbonyl)-1-guanylpyr 1H-Pyrazole-1-carboxamidine, N,N'-Bis-BOC protected 97% 1-[N,N'-Bis(tert-butoxycarbonyl)amidino]pyrazole Boc-Pyrazol N,N'-Di-Boc-1H-pyrazole-1-carboxamide N,N'-Bis-Boc-1-Guanylpyrazol Bis-Boc-pyrazolocarboxamidine 1H-Pyrazole-1-carboxamidine, N,N'-Bis-BOC protected N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboximidamide Pyrazol(Boc)2 N,N'-Bis-Boc-1-Guanylpyrazole Tert-butyl (1H-pyrazol-1-yl) MethanediylidenedicarbaMate N,N'-Di-Boc-1H-pyrazole-1-carboxaMidine, 98+% N,N'-Di-Boc-1H-pyrazole-1-carboxamidine 1-[N,N'-bis(tert-butoxycarbonyl)amidino]pyrazole 1-[N,N'-(Di-Boc)amidino]pyrazole Pyrazol(Boc)2 N,N'-Bis-Boc-1-Guanylpyrazol tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazol-1-ylMethylene]-, 1,1-diMethylethyl ester tert-butyl N-[(tert-butoxy)carbonyl]-N-[(1H-pyrazol-1-yl)carbonyl]carbaMate N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboximidamide, 1-[N,N'-Bis(tert-butoxycarbonyl)carbamimidoyl]-1H-pyrazole tert-Butyl (((tert-butoxycarbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate, 95+% N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine > N,N'-Bis-boc-1-g uanyL N,N'-Bis-boc-1-guanyL 1-[N,N'-(Di-Boc)amidino]pyrazole 1-[N,N'-Bis(tert-butoxycarbonyl N,N'-Di-Boc-1H-pyrazole-1-carboximidamide tert-butyl -N-[[(2-methylpropan-2-yl)oxycarbonylamino]-pyrazol-1-ylmethylidene]carbamate 152120-54-2 N,N'-BIS-BOC-1-GUANYLPYRAZOLE tert-butyl (NZ)-N-[[(2-methylpropan-2-yl)oxycarbonylamino]-pyrazol-1-ylmethylidene]carbamate Zanamivir / ranimivir intermediate N. N '- Di Boc-1H-1-Guanylpyrazole Pyrazol(Boc)2N,N'-Bis-Boc-1-Guanylpyrazol N,N'-Di-Boc-pyrazole-1-carboxamidine Laninamivir Impurity 4 N,N′-Di-Boc-1H-pyrazole-1-carboxamidine N,N′-Di-Boc-1H-pyrazole-1-carboxamidine, CAS 152120-54-2 N,N'-Di-Boc-1H-pyrazole-1-carboxamidine tert-Butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate tert-Butyl (NZ)-N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate tert-butyl N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate N,N'-Bis-Boc-1-guanylpyrazole 1,3-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 152120-54-2 C14H22N4O4 Specialty Synthesis Peptide Synthesis Guanidine Protection/Guanidinylation