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L-4-Benzoylphenylalanine

L-4-Benzoylphenylalanine structure

CAS No.: 104504-45-2

Chemical Name:: L-4-Benzoylphenylalanine

Synonyms: (S)-2-aMino-3-(4-benzoylphenyl)propanoic acid;(2S)-2-aMino-3-(4-benzoylphenyl)propanoic acid;4-BENZOYL-L-PHENYLALANINE;H-BPA-OH;H-PHE(4-BZ)-OH;P-BENZOYL-L-PHENYLALANINE;Al660-1;L-Bpa-OH;H-4-Bz-Phe-Oh;H-P-BZ-PHE-OH

CBNumber:: CB3686238

Molecular Formula:: C16H15NO3

Molecular Weight:: 269.3

MDL Number:: MFCD00238102

MOL File:: 104504-45-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:08

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L-4-Benzoylphenylalanine Properties

Boiling point	467.6±40.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMF: insol; DMSO: insol; Ethanol: insol; PBS (pH 7.2): insol
form	A solid
pka	2.16±0.10(Predicted)
color	White to light yellow
InChI	InChI=1S/C16H15NO3/c17-14(16(19)20)10-11-6-8-13(9-7-11)15(18)12-4-2-1-3-5-12/h1-9,14H,10,17H2,(H,19,20)/t14-/m0/s1
InChIKey	TVIDEEHSOPHZBR-AWEZNQCLSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(C(=O)C2=CC=CC=C2)C=C1)N
FDA UNII	9RU6KQ9WYD

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H227

Precautionary statements

P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235

Safety Statements

24/25

HS Code

29225090

NFPA 704

	1
0		0

L-4-Benzoylphenylalanine price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	36168	p-Benzoyl-L-phenylalanine ≥95%	104504-45-2	500mg	$36	2026-04-30	Buy
Cayman Chemical	36168	p-Benzoyl-L-phenylalanine ≥95%	104504-45-2	1g	$68	2026-04-30	Buy
Cayman Chemical	36168	p-Benzoyl-L-phenylalanine ≥95%	104504-45-2	5g	$227	2026-04-30	Buy
Usbiological	264983	4-Benzoyl-L-phenylalanine Asreported	104504-45-2	500mg	$333	2026-06-03	Buy
Usbiological	264983	4-Benzoyl-L-phenylalanine Asreported	104504-45-2	1g	$542	2026-06-03	Buy

Product number	Packaging	Price	Buy
36168	500mg	$36	Buy
36168	1g	$68	Buy
36168	5g	$227	Buy
264983	500mg	$333	Buy
264983	1g	$542	Buy

L-4-Benzoylphenylalanine Chemical Properties, Uses, Production

Chemical Properties

Off-white solid

Uses

4-Benzoyl-L-phenylalanine is a photoreactive amino acid which can easily be incorporated into a peptide by solid-phase synthesis and finds application as phtolabel. It is an important raw material as well as an intermediate in organic synthesis.

Synthesis

63-91-2

98-88-4

104504-45-2

The general procedure for the synthesis of (S)-2-amino-3-(4-benzoylphenyl)propionic acid from L-phenylalanine and benzoyl chloride was as follows: in a reaction tube fitted with a screw cap and polytetrafluoroethylene (PTFE)-faced rubber lining, L-phenylalanine (16.5 mg, 0.1 mmol) was added followed by trifluoromethanesulfonic acid (0.5 mL). After the solution was homogenized, benzoyl chloride (8 eq.) was added slowly at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the mixture was poured into a mixture of cold water and ethyl acetate. The organic layer was separated, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated and the residue was purified by silica gel column chromatography (eluent ratio ethyl acetate:methanol:water=8:1:0.5) to give a colorless amorphous product (7.5 mg, 28% yield, 98% enantiomeric excess value). The structure of the product was confirmed by 1H-NMR (CD3OD): δ 7.76 (d, 2H, J=8.6 Hz, Ar), 7.75 (d, 2H, J=8.6 Hz, Ar), 7.64 (t, 1H, J=7.4 Hz, Ar), 7.52 (t, 2H, J=7.4 Hz, Ar), 7.47 (d, 2H, J=8.0 Hz, Ar ), 3.83(m, 1H, Hα), 3.35(m, 1H, Hβ), 3.09(m, 1H, Hβ).

storage

Store at +4°C

References

[1] Molecules, 2013, vol. 18, # 7, p. 8393 - 8401
[2] Heterocycles, 2013, vol. 87, # 10, p. 2119 - 2126

L-4-Benzoylphenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine Benzoyl chloride

Preparation Products

L-4-Benzoylphenylalanine Suppliers

Global Suppliers ( 136)

Supplier	Tel	Email	Country	ProdList	Advantage
Amatek Scientific Co. Ltd.	0512-56316828 4008675858	sales@amateksci.com	China	9848	55
Nanjing Derno Pharmaceutical Technology Co., Ltd.	02585057128;025-86957866 13952093866	sales@dernopharm.com	China	943	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Suzhou haiyu Biochem Industrial Co., LTD	512-68097639 18013585858	744942877@qq.com	China	915	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
ChemPep, Inc.	+1 (888) 615-9178 / (561) 791-8787	service@chempep.com	United States	2138	57

Supplier	Advantage
Amatek Scientific Co. Ltd.	55
Nanjing Derno Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Shanghai HC Biotech Co., Ltd	55
Alfa Aesar	84
Beijing HwrkChemical Technology Co., Ltd	55
Suzhou haiyu Biochem Industrial Co., LTD	62
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
ChemPep, Inc.	57

View Latest Price from L-4-Benzoylphenylalanine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-15	4-Benzoyl-L-phenylalanine 104504-45-2	$29.00		98.01%	10g	TargetMol Chemicals Inc.
	2019-07-06	L-4-BENZOYLPHENYLALANINE 104504-45-2	$1.00	1kg	98%	100KG	Career Henan Chemical Co

4-Benzoyl-L-phenylalanine
104504-45-2
$29.00
98.01%
TargetMol Chemicals Inc.

L-4-BENZOYLPHENYLALANINE
104504-45-2
$1.00
98%
Career Henan Chemical Co

L-4-Benzoylphenylalanine Spectrum

L-4-BENZOYLPHENYLALANINE(104504-45-2)¹HNMR

104504-45-2 (L-4-Benzoylphenylalanine) Related Search:

4-Methylphenyl-L-alanine L-Phe(4-COCH3) H-Phe(4-Cl)-OMe.HCl 4-Amino-L-phenylalanine hydrochloride L-4-Cyanophenylalanine

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(S)-2-aMino-3-(4-benzoylphenyl)propanoic acid p-benzoyl-L-phenylanaline H-4-Bz-Phe-Oh H-Bpa-OH H-Phe(4-Bz)-OH L-4-BENZOYLPHENYLALANINE 1G H-Bpa-OH H-Phe(4-Bz) 4-Benzoyl-L-phenylalanine≥ 99% (HPLC, Chiral purity) H-L-Phe(4-Bz)-OH L-Bpa-OH P-BENZOYL-L-PHENYLALANINE P-BZ-PHENYLALANINE L-P-BENZOYLPHENYLALANINE H-PHE(P-BZ)-OH H-PHE(4-BZO)-OH H-P-BZ-PHE-OH H-BPA-OH 4-Benzoylphenylalanine Al660-1 4-Benzoyl-L-phenylalanine，98% L-Phenylalanine, 4-benzoyl- (S)-2-Amino-3-(4-benzoylphenyl)propanoicaci (S) 2-Amino-3- (4-benzoylphenyl) propionic acid (R)-3-amino-3-(3-(p-tolyloxy)phenyl)propanoic acid (2S)-2-aMino-3-(4-benzoylphenyl)propanoic acid 4-BENZOYL-L-PHENYLALANINE H-PHE(4-BZ)-OH L-4-Benzoylphenylalanine 104504-45-2 Phenylalanine analogs and other aromatic alpha amino acids Amino Acid Derivatives Amino Acids proteins Chiral Compound a-amino