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4-Amino-L-phenylalanine

4-Amino-L-phenylalanine Structure
4-Amino-L-phenylalanine structure
CAS No.
943-80-6
Chemical Name:
4-Amino-L-phenylalanine
Synonyms
(S)-2-AMINO-3-(4-AMINOPHENYL)PROPANOIC ACID;p-Aminophenylalanine;4-Amino-L;4-Amino-Phe;L-4-AMINOPHE;4-Amino-L-Phe;L-4-NH2-Phe-OH;4-Amino-Phe-OH;H-PHE(4-NH2)-OH;H-PHE(4'-NH2)-OH
CBNumber:
CB1722156
Molecular Formula:
C9H12N2O2
Molecular Weight:
180.2
MDL Number:
MFCD00069927
MOL File:
943-80-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:44:08
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4-Amino-L-phenylalanine Properties

Melting point 265 °C (decomp)
Boiling point 383.5±32.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol (Slightly, Sonicated), Water (Slightly, Sonicated)
form Solid
pka 2.14±0.10(Predicted)
color Pale Beige to Beige
Water Solubility Soluble in water.
Sensitive Air Sensitive
CAS DataBase Reference 943-80-6(CAS DataBase Reference)
FDA UNII 1567B560CH

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  2922498590
NFPA 704
0
0 0

4-Amino-L-phenylalanine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 232813 4-Amino-L-phenylalanine 99+% (HPLC) ≥99%(HPLC) 1g $170 2026-06-03 Buy
Usbiological 232813 4-Amino-L-phenylalanine 99+% (HPLC) ≥99%(HPLC) 5g $245 2026-06-03 Buy
Usbiological 232813 4-Amino-L-phenylalanine 99+% (HPLC) ≥99%(HPLC) 25g $588 2026-06-03 Buy
Usbiological 232813 4-Amino-L-phenylalanine 99+% (HPLC) ≥99%(HPLC) 100g $1361 2026-06-03 Buy
TRC TRC-A622376-25G p-Amino-L-phenylalanine 943-80-6 25g $1528 2026-06-03 Buy
Product number Packaging Price Buy
232813 1g $170 Buy
232813 5g $245 Buy
232813 25g $588 Buy
232813 100g $1361 Buy
TRC-A622376-25G 25g $1528 Buy

4-Amino-L-phenylalanine Chemical Properties, Uses, Production

Chemical Properties

Off-white crystalline powder

Uses

It finds its application in the purification of peptide synthetases involved in pristinamycin I biosynthesis.

Definition

ChEBI: 4-amino-L-phenylalanine is the L-enantiomer of 4-aminophenylalanine. It is an enantiomer of a 4-amino-D-phenylalanine. It is a tautomer of a 4-amino-L-phenylalanine zwitterion.

Synthesis

4-Nitro-3-phenyl-L-alanine

949-99-5

4-Amino-L-phenylalanine

943-80-6

A mixed solution of concentrated HNO3 (60%) and concentrated H2SO4 (1.4:1.1 v/v) was prepared and cooled to 10°C. A portion of the mixed solution (3.5 mL) was slowly added dropwise to a solution of L-phenylalanine (4.139 g, 25.1 mmol) in H2SO4 (98%, 12.5 mL) with stirring. The reaction mixture was kept stirred at 10 °C for 2.5 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted with NH4OH to 5. The resulting light yellow precipitate was collected by filtration, washed sequentially with a small amount of water and CH3CN, and dried to give 4-nitro-L-phenylalanine as a yellow powder (4.748 g, 90% yield). 4-Nitro-L-phenylalanine (2.006 g, 9.54 mmol) was suspended in water (35 mL), 0.2 g of 5% palladium-barium sulfate catalyst was added, and the hydrogenation reaction was carried out for 3 h at room temperature. The reaction solution was filtered through a diatomaceous earth pad and the filtrate was concentrated to give a light brown residue. The residue was washed with CH3CN to give a light brown solid (1.460 g, 85% yield) which was used directly in the next step of the reaction. 4-Amino-L-phenylalanine derivative (0.060 g, 0.33 mmol) was dissolved in 6N HCl (4 mL) and aqueous sodium nitrate solution (0.030 g/0.5 mL) was slowly added at 0 °C. The reaction mixture was stirred at the same temperature for 40 min and then diluted with 6N HCl (0.25 mL). Subsequently, aqueous sodium azide solution (0.033 g/0.75 mL) was added at 0 °C. The reaction mixture was stirred at 0 °C for 5 min and then warmed up to room temperature to continue the reaction for 1 h. The reaction mixture was then concentrated and the reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was concentrated and the residue was reprecipitated by CH3CN to give a pure colorless amorphous solid (0.0435 g, 64% yield). The analytical and spectroscopic data of the product were in agreement with literature reports [10].

IC 50

Human Endogenous Metabolite

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 466 - 470
[2] Molecules, 2013, vol. 18, # 7, p. 8393 - 8401
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 80,83
[4] Chemistry Letters, 1998, # 7, p. 704 - 706
[5] Chemistry Letters, 1998, # 6, p. 537 - 538

4-Amino-L-phenylalanine Preparation Products And Raw materials

Raw materials

4-Nitro-3-phenyl-L-alanine Hydrogen

Preparation Products

Boc-Tyr(3,5-Br2)-OH

4-Amino-L-phenylalanine Suppliers

Global Suppliers ( 237)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Shanghai HC Biotech Co., Ltd 55
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Suzhou haiyu Biochem Industrial Co., LTD 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66

View Latest Price from 4-Amino-L-phenylalanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-L-phenylalanine pictures 2025-12-24 4-Amino-L-phenylalanine
943-80-6
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
4-Amino-L-phenylalanine pictures 2021-07-13 4-Amino-L-phenylalanine
943-80-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-Amino-L-phenylalanine pictures 2019-07-06 4-Amino-L-phenylalanine
943-80-6
 $8.00 1kg 99% 10MT Career Henan Chemical Co

4-Amino-L-phenylalanine Spectrum

4-Amino-L-phenylalanine(943-80-6)1HNMR

943-80-6 (4-Amino-L-phenylalanine) Related Search:

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L-4-Chlorophenylalanine L-4-Fluorophenylalanine 4-Nitro-3-phenyl-L-alanine O-Methyl-L-tyrosine L-4-Benzoylphenylalanine
L-Phe(4-COCH3) L-4-Aminomethylphe 4-Bromo-L-phenylalanine

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4-Amino-Phe L-4-NH2-Phe-OH 4-AMINO-L-PHENYLALANINE 99% L-2-Amino-3-(4-amino-phenyl)-propionic acid H-L-Phe(4-NH2)-OH 4-Amino-L-Phe Aminophenyalanine (2S)-2-amino-3-(4-aminophenyl)propionic acid (2S)-2-azanyl-3-(4-azanylphenyl)propanoic acid 4-Amino-L-phenylalan L-4-NH2-Phe-OH 4-AMino-L-Phenylalanine para-Aminophenylalanine Phenylalanine, 4-amino- L-4-AMINOPHE L-4-AMINOPHENYLALANINE L-4-AMINOPHENYLALANINE DIHYDROCHLORIDE H-PHE(P-NH2)-OH 2HCL H-PHE(4-NH2)-OH H-PHE(4-NH2)-OH 2HCL H-P-AMINO-L-PHE-OH L-P-AMINOPHENYLALANINE 2HCL 4-AMINO-PHENYLALANINE 4-AMINO-L-PHENYLALANINE P-AMINO-L-PHENYLALANINE H-PHE(4'-NH2)-OH 4-Amino-L-phenylalanine≥ 99% (HPLC) π-Amino-L-phenylalanine 4-Amino-Phe-OH (2R)-2-amino-3-(4-aminophenyl)propanoic acid 4-amino-pyenylalanine 4-Amino-L L-Phenylalanine, 4-amino- 4-Amino-L-phenylalanine,95% 4-Amino-L-phenylalanine USP/EP/BP Melphalan Impurity 28 (S)-2-AMINO-3-(4-AMINOPHENYL)PROPANOIC ACID p-Aminophenylalanine 943-80-6 C9H12N2O2 Carboxylic acid Amines Phenylalanine [Phe, F] a-amino Phenylalanine analogs and other aromatic alpha amino acids Unusual Amino Acids Amino Acids 13C, 2H, 15N Chiral Compound Amino Acids