L-Alanine methyl ester hydrochloride
- CAS No.
- 2491-20-5
- Chemical Name:
- L-Alanine methyl ester hydrochloride
- Synonyms
- METHYL L-ALANINATE HYDROCHLORIDE;ALANINE METHYL ESTER HYDROCHLORIDE;ALA-OME.HCL;ALANINE-OME HCL;L-Ala-OMe.HCL;L-ALANINE METHYL ESTER HCL;L-ALANINE METHYL ESTER HYDROCHLORIDE SALT;(S)-Methyl 2-aMinopropanoate hydrochloride;L-alanina;anine methyL
- CBNumber:
- CB7715055
- Molecular Formula:
- C4H10ClNO2
- Molecular Weight:
- 139.58
- MDL Number:
- MFCD00063663
- MOL File:
- 2491-20-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 109-111 °C(lit.) |
|---|---|
| alpha | 7 º (c=2, CH3OH 24 ºC) |
| refractive index | 6.5 ° (C=2, MeOH) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Powder |
| color | White to off-white |
| optical activity | [α]25/D +7.0°, c = 1.6 in methanol |
| Water Solubility | Soluble in Water (100 mg/ml). |
| Sensitive | Hygroscopic |
| BRN | 3594033 |
| Major Application | peptide synthesis |
| InChI | InChI=1/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/s3 |
| InChIKey | IYUKFAFDFHZKPI-OQFXAWDINA-N |
| SMILES | C(=O)(OC)[C@@H](N)C.Cl |&1:4,r| |
| CAS DataBase Reference | 2491-20-5(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
L-Alanine methyl ester hydrochloride price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 330639 | L-Alanine methyl ester hydrochloride 99% | 2491-20-5 | 5g | $42.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 330639 | L-Alanine methyl ester hydrochloride 99% | 2491-20-5 | 25g | $123 | 2026-04-30 | Buy |
| Sigma-Aldrich | S378909 | ALANINE METHYL ESTER HYDROCHLORIDE AldrichCPR | 2491-20-5 | 250MG | $159 | 2022-05-15 | Buy |
| TCI Chemical | A1466 | L-Alanine Methyl Ester Hydrochloride >98.0%(T) | 2491-20-5 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | A1466 | L-Alanine Methyl Ester Hydrochloride >98.0%(T) | 2491-20-5 | 25g | $72 | 2026-04-30 | Buy |
L-Alanine methyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
L-Alanine methyl ester hydrochloride is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
56-41-7
2491-20-5
The general procedure for the synthesis of (S)-alanine methyl ester hydrochloride (1a) from methanol and L-alanine was as follows: 15 mL of anhydrous methanol was first added to a round-bottomed flask according to the literature (Xing et al., 2012). At -15 °C, 2.16 mL of SOCl2 (0.03 mol) was slowly added dropwise to methanol and the reaction was maintained at 0 °C for 1 hour. Another round bottom flask was taken and 14 mL of anhydrous methanol and 1.4 mL (0.019 mol) of SOCl2 was added followed by 1.118 g of L-alanine and heated to reflux for 1.5 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure, and the pre-prepared SOCl2 solution was poured into the reaction flask and refluxing was continued for 1.5 h to give product 1a (100% yield). Since the hydrochloric acid generated by the reaction was not favorable for the subsequent steps, NaHCO3 was added to the reaction flask at the end of reflux to neutralize the acidity until no bubbles were generated. Finally, the solution was concentrated to obtain 1b (100% yield). Fusaric acid (4) was dissolved with 1b in 15 mL of dichloromethane in a round-bottomed flask with homogeneous stirring, followed by the addition of excess catalysts dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), and refluxed for 24 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by preparative HPLC (25-45% CH3CN/H2O, 20 min) to afford the product 1c (52% yield).
References
[1] Phytochemistry Letters, 2018, vol. 26, p. 50 - 54
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 36, p. 11683 - 11687
[3] Angew. Chem., 2018, vol. 130, # 36, p. 11857 - 11861,5
[4] Journal of Organic Chemistry, 2008, vol. 73, # 7, p. 2898 - 2901
[5] Tetrahedron Asymmetry, 2009, vol. 20, # 9, p. 1036 - 1039
L-Alanine methyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Xinkang Pharmaceutical Chemical Co., Ltd | 027-027-59308705 18871579363 | 1248680011@qq.com | China | 9279 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9618 | 58 |
| Hubei Hengluyuan Technology co.ltd | 027-88188016 18717196322 | 1764683941@qq.com | China | 5944 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 15558396803 | sales@nbinno.com | China | 135 | 58 |
| Awesome （Beijing）TechnologyCo.,Ltd. | 18201687790 18201687790 | yunbo12291229@163.com | China | 137 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
View Lastest Price from L-Alanine methyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | L-Ala-Ome.Hcl
2491-20-5
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-09-02 | L-Alanine methyl ester hydrochloride
2491-20-5
|
$2.00-5.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | L-Alanine methyl ester hydrochloride
2491-20-5
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- L-Ala-Ome.Hcl
2491-20-5
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Alanine methyl ester hydrochloride
2491-20-5
- $2.00-5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- L-Alanine methyl ester hydrochloride
2491-20-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
L-Alanine methyl ester hydrochloride Spectrum
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