Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester
- CAS No.
- 212650-43-6
- Chemical Name:
- Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester
- Synonyms
- 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID;4-Boc-3-morpholinecarboxylic acid;4-Boc-morpholine-3-carboxylic acid;4-N-BOC-3-MORPHOLINECARBOXYLIC ACID;(R/S)-BOC-3-CARBOXYMORPHOLINE;N-Boc-morpholine-3-carboxylic acid;N-Boc-Morpholine-2-carboxylic acid;4-N-Boc-Morpholine-3-carboxylic acid;Morpholine-3,4-dicarboxylic acid 4-tert-butyl;4-tert-Butoxymethyl-morpholine-3-carboxylic acid
- CBNumber:
- CB3739349
- Molecular Formula:
- C10H17NO5
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD02683057
- MOL File:
- 212650-43-6.mol
- MSDS File:
- SDS
| Boiling point | 369℃ |
|---|---|
| Density | 1.230 |
| Flash point | 177℃ |
| storage temp. | 2-8°C |
| pka | 3.53±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13) |
| InChIKey | KVXXEKIGMOEPSA-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCOCC1C(O)=O |
| CAS DataBase Reference | 212650-43-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-51-36 |
| Safety Statements | 26-36/37/39 |
Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 66848 | N-BOC-MORPHOLINE-3CARBOXYLIC ACID 97% | 212650-43-6 | 1G | $25 | 2026-04-30 | Buy |
| AstaTech | 66848 | N-BOC-MORPHOLINE-3CARBOXYLIC ACID 97% | 212650-43-6 | 5G | $69 | 2026-04-30 | Buy |
| AstaTech | 66848 | N-BOC-MORPHOLINE-3CARBOXYLIC ACID 97% | 212650-43-6 | 25G | $278 | 2026-04-30 | Buy |
| Matrix Scientific | 072642 | 4-Boc-3-Morpholinecarboxylic acid | 212650-43-6 | 1.00g | $347 | 2026-05-18 | Buy |
| Matrix Scientific | 072642 | 4-Boc-3-Morpholinecarboxylic acid | 212650-43-6 | 5.00g | $998 | 2026-05-18 | Buy |
Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester Chemical Properties, Uses, Production
Uses
Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester is an organic heterocyclic compound that can be used in decarboxylation arylation reactions to prepare other compounds. It is also used as a synthetic intermediate component in the preparation of substances such as thienopyrrole compounds, pyridine derivatives and cyclised acetamide derivatives.
Synthesis
77873-76-8
24424-99-5
212650-43-6
The general procedure for the synthesis of 4-Boc-3-morpholinecarboxylic acid from 3-morpholinecarboxylic acid and di-tert-butyl dicarbonate is as follows: di-tert-butyl dicarbonate (3.33 g, 15.3 mmol) was slowly added to acetone (5 mL) and water (0 mL) containing morpholine-3-carboxylic acid (1.7 g, 10.2 mmol), potassium carbonate (7.04 g, 51 mmol) in a 0°C in a mixed solution. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction solution was diluted with water (50 mL) and extracted with ether (2 x 50 mL). The aqueous phase was acidified with 2M aqueous hydrochloric acid (100 mL) and then extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the white solid product 4-Boc-3-morpholinecarboxylic acid (1.98 g, 84% yield). The product was characterized by 1H NMR (CDCl3), δ (ppm): 4.46 (m, 2H), 3.80 (m, 3H), 3.53 (m, 1H), 3.31 (m, 1H), 1.48 (d, 9H).
References
[1] Patent: WO2005/80386, 2005, A1. Location in patent: Page/Page column 40
[2] Angewandte Chemie - International Edition, 2018,
[3] Angew. Chem., 2018, vol. 130, # 44, p. 14768 - 14773,6
[4] Patent: WO2009/67233, 2009, A1. Location in patent: Page/Page column 46-47
Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai ZiHao Pharmaceutical Co., Ltd. | 021-13482410-12 13482410112; | 362383684@qq.com | China | 751 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Chengdu jingzhihuacheng Chemical Technology Co., Ltd. | 028-028-37664989 15900794981 | jingzhichem@163.com | China | 536 | 55 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1846 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
212650-43-6
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2019-07-06 | MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
212650-43-6
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
212650-43-6
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
212650-43-6
- $1.00
- 98%
- Career Henan Chemical Co
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