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DELTORPHIN II

DELTORPHIN II Structure
DELTORPHIN II structure
CAS No.
122752-16-3
Chemical Name:
DELTORPHIN II
Synonyms
DADELT II;Declostatin;DELTORPHIN B;Deltorphin 2;DELTORPHIN II;Deltorphin 2(TFA);ala(2)-deltorphini;DAla2]Deltorphin B;DELTORPHIN 2?, >98%;Y-{d-Ala}-FEVVG-NH2
CBNumber:
CB3759219
Molecular Formula:
C38H54N8O10
Molecular Weight:
782.88
MDL Number:
MFCD00080072
MOL File:
122752-16-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:31
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DELTORPHIN II Properties

Boiling point 1256.2±65.0 °C(Predicted)
Density 1.272±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble to 1 mg/ml in 10% acetonitrile
form solid
pka 4.43±0.10(Predicted)
color White
biological source synthetic (organic)
Water Solubility Soluble to 1 mg/ml in water
InChIKey NUNBRHVOPFWRRG-RCEFDBTISA-N
SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)C)C(=O)NCC(N)=O
UNSPSC Code 12352209
NACRES NA.32

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

DELTORPHIN II price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T0675 [D-Ala2]-Deltorphin II ≥97% (HPLC) 122752-16-3 1mg $128 2026-04-30 Buy
Usbiological 255085 [D-Ala2]-Deltorphin II Asreported 122752-16-3 1mg $339 2026-06-03 Buy
Biosynth VAC-00826 [D-Ala2] Deltorphin II 5mg $229.9 2026-06-05 Buy
Biosynth VAC-00826 [D-Ala2] Deltorphin II 10mg $390.3 2026-06-05 Buy
Biosynth VAC-00826 [D-Ala2] Deltorphin II 25mg $689.75 2026-06-05 Buy
Product number Packaging Price Buy
T0675 1mg $128 Buy
255085 1mg $339 Buy
VAC-00826 5mg $229.9 Buy
VAC-00826 10mg $390.3 Buy
VAC-00826 25mg $689.75 Buy

DELTORPHIN II Chemical Properties, Uses, Production

Uses

[D-Ala2]-Deltorphin II (cas# 122752-16-3) is a useful research chemical.Deltorphin II is one of the naturally occurring peptides with high affinity and selectivity for δ-opioid binding sites. Deltorphin II showed even higher affinity for δ-opioid receptors than previously characterized deltorphins. Also, Deltorphin II were identified as new transport substrates of OATP-A

Definition

ChEBI: Deltorphin B is a peptide.

Biological Activity

[d-ala2]-deltorphin ii (dadelt ii) is a natural agonist of δ opioid receptor with ki or ic50 value of 0.41 nm [1, 2].opioid receptors are most abundant in the central nervous system, but are also localized in many peripheral tissues in mammalian organisms. there are three types of opioid receptors that are well-defined; the μ, δ and κ receptors [2].[d-pen2, d-pen5]enkephalin (dpdpe) is a second highly selective agonist of δ [3]. treatment with dpdpe at 1 m for as short as 3 min significantly diminished the inhibition of the opioid receptor in ng108-15 cells to cyclic amp production. that means neuronal delta opioid receptor underwent acute desensitization. this desensitization was temporally parallel to the phosphorylation of delta opioid receptor 3 min. after agonist stimulation [4].i.c.v. administration of dadelt ii from 0.38-12.78 nm resulted in a dose- and time-related antinociception. 10 min after the administration of dadelt ii, the maximal antinociceptive response was seen. until 60 min after the administration of dadelt ii, effects were detected. these antinociceptive effects of i.c.v. dadelt ii were antagonized by the selective δ antagonist, ici 174,864 [3]. after supraspinal and spinal administration in rats intracerebroventricularly, dadelt ii at 0.2, 1, 10 μg/rat in a dose-related fashion inhibited diarrhea and colonic bead expulsion but did not show any effect on the rate of small intestine transit. spinal administration of dadelt ii at the same dose produced similar results. naltrindole is a selective antagonist of the δ opioid receptor. subcutaneous pretreatment with naltrindole at 1 and 10 mg/kg antagonized effects of dadelt ii partially and completely, respectively [1].

Biochem/physiol Actions

Selective δ2 opioid receptor agonist

storage

Store at -20°C

References

[1]. broccardo m, improta g. antidiarrheal and colonic antipropulsive effects of spinal and supraspinal administration of the natural δ opioid receptor agonist,[d-ala2] deltorphin ii, in the rat. european journal of pharmacology, 1992, 218(1): 69-73.
[2]. janecka a, fichna j, janecki t. opioid receptors and their ligands. current topics in medicinal chemistry, 2004, 4(1): 1-17.
[3]. jiang q, mosberg hi, porreca f. antinociceptive effects of [d-ala2] deltorphin ii, a highly selective δ agonist in vivo. life sciences, 1990, 47(11): pl43-pl47.
[4]. cai y, zhang y, wu y, et al. δ opioid receptor in neuronal cells undergoes acute and homologous desensitization. biochemical and biophysical research communications, 1996, 219(2): 342-347.

DELTORPHIN II Preparation Products And Raw materials

Raw materials

Preparation Products

DELTORPHIN II Suppliers

Global Suppliers ( 133)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1010 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Cellmano Biotech Limited 55
MedChemexpress LLC 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Sigma-Aldrich 80
Shanghai YuanYe Biotechnology Co., Ltd. 60
Nanjing Leon Biological Technology Co., Ltd. 55

View Latest Price from DELTORPHIN II manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DELTORPHIN II pictures 2025-08-22 DELTORPHIN II
122752-16-3
 1GRAM 99% 20 TONS Dingwang Technology (Wuhan) Co., Ltd.
DELTORPHIN II pictures 2025-06-20 DELTORPHIN II
122752-16-3
 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
  • DELTORPHIN II pictures
  • DELTORPHIN II
    122752-16-3
  • $0.00
  • 99%
  • Dingwang Technology (Wuhan) Co., Ltd.

122752-16-3 (DELTORPHIN II) Related Search:

Bismuth hydroxide nitrate oxide, BiO5.1 Deltorphin II, (2-D-Ala), [tyrosyl-3,5-3H]- DELTORPHIN I DELTORPHIN deltorphin II, Ile(5,6)-
Deltorphin II [D-Ala2] Deltorphin II (Deltorphin B) DELTORPHIN II

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M.W. 782.89 C38H54N8O10 [D-Ala2,Glu4]deltorphin C [D-Ala2,Glu4]Deltorphin II DADELT II H-TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2 DELTORPHIN B DELTORPHIN II [D-ALA2]-DELTORPHIN II TYR-D-ALA-PHE-GLU-VAL-VAL-GLY AMIDE TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2 ala(2)-deltorphini deltorphin II, Ala(2)- Deltorphin 2 Deltorphin 2(TFA) Deltorphin 2,[D-Ala2]-Deltorphin II, >98% DELTORPHIN 2?, >98% Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-glutamyl-L-valyl-L-valyl- D-Ala2]-Deltorphin II >=97% (HPLC) Declostatin Y-{d-Ala}-FEVVG-NH2 Deltorphin 2(TFA)|||[D-Ala2]-Deltorphin II Deltorphin II TFA Salt [D-Ala2]-Deltorphin II, Selective delta opioid receptor agonist Deltorphin B - 1 mg [D-Ala2]-Deltorphin II DAla2]Deltorphin B 122752-16-3 C38H54N8O10 Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Opioid Peptides Other Opioid Peptides Opioid receptor and opioid-like receptor