ChemicalBook >> CAS DataBase List >>HEXANOIC ANHYDRIDE

HEXANOIC ANHYDRIDE

HEXANOIC ANHYDRIDE structure

CAS No.: 2051-49-2

Chemical Name:: HEXANOIC ANHYDRIDE

Synonyms: CAPROIC ANHYDRIDE;N-HEXANOIC ANHYDRIDE;hexanoylhexanoate;N-HEXOIC ANHYDRIDE;Capronic anhydride;Hexanoyl anhydride;n-Capriocanhydride;HEXANOIC ANHYDRIDE;N-CAPROIC ANHYDRIDE;N-CAPRONIC ANHYDRIDE

CBNumber:: CB3766110

Molecular Formula:: C12H22O3

Molecular Weight:: 214.3

MDL Number:: MFCD00009509

MOL File:: 2051-49-2.mol

MSDS File:: SDS

Last updated:2026-07-01 20:51:29

Request For Quotation

HEXANOIC ANHYDRIDE Properties

Melting point	-40 °C
Boiling point	246-248 °C (lit.)
Density	0.928 g/mL at 20 °C (lit.)
vapor pressure	2.9Pa at 25℃
refractive index	n20/D 1.428(lit.)
Flash point	>230 °F
storage temp.	Store below +30°C.
solubility	ethanol: soluble1g/10 mL, clear, colorless
form	Liquid
color	Clear colorless to light yellow
explosive limit	0.7%(V)
Water Solubility	Hydrolyzes in water.
Sensitive	Moisture Sensitive
BRN	1776561
InChI	1S/C12H22O3/c1-3-5-7-9-11(13)15-12(14)10-8-6-4-2/h3-10H2,1-2H3
InChIKey	PKHMTIRCAFTBDS-UHFFFAOYSA-N
SMILES	CCCCCC(=O)OC(=O)CCCCC
LogP	4.45 at 25℃
CAS DataBase Reference	2051-49-2(CAS DataBase Reference)
FDA UNII	GG70Y8LTBY
EPA Substance Registry System	Hexanoic acid, anhydride (2051-49-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29159000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

REACH Registrations

Active

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

HEXANOIC ANHYDRIDE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	194530	Hexanoic anhydride 97%	2051-49-2	50g	$51.7	2026-04-30	Buy
Sigma-Aldrich	21580	Hexanoic anhydride purum, ≥97.0% (GC)	2051-49-2	250ML	$78.1	2026-04-30	Buy
Sigma-Aldrich	194530	Hexanoic anhydride 97%	2051-49-2	250g	$101	2026-04-30	Buy
Sigma-Aldrich	21580	Hexanoic anhydride purum, ≥97.0% (GC)	2051-49-2	50mL	$33	2023-06-20	Buy
TCI Chemical	C0021	Hexanoic Anhydride >96.0%(GC)	2051-49-2	25mL	$17	2026-04-30	Buy

Product number	Packaging	Price	Buy
194530	50g	$51.7	Buy
21580	250ML	$78.1	Buy
194530	250g	$101	Buy
21580	50mL	$33	Buy
C0021	25mL	$17	Buy

HEXANOIC ANHYDRIDE Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Hexanoic anhydride has been used in:

green synthesis of esters of acyclovir (acyclovir prodrugs)
preparation of hexanoyl-modified chitosan nanoparticles and chitosan-based polymeric surfactants via N-acylation of chitosans

Uses

Hexanoic anhydride was used in:

green synthesis of esters of acyclovir (acyclovir prodrugs)
preparation of hexanoyl-modified chitosan nanoparticles
preparation of chitosan-based polymeric surfactants via N-acylation of chitosans

Uses

Hexanoic Anhydride, is used as a reactant in the total synthesis of acremomannolipin A via steroselective β-mannosylation of 4,6,-O-benzylidene-protected mannosyl sulfoxide with a D-mannitol derivative.

Preparation

To an ice-cooled flask containing 116 gm (1.0 mole) of n-caproic acid is added 21.0-23.10 gm (0.5-0.55 mole) of ketene at a rate of 0.45 mole/hr. The reaction mixture is fractionally distilled at atmospheric pressure to afford a forecut of acetone, acetic acid, and acetic anhydride. The oil bath is raised to 220°C over a 1-hr period, kept there for 3 hr to ensure complete removal of acetic acid, and then cooled. The distillation is continued under reduced pressure to afford 86-95 gm (80-87%), b.p. 109- 112°C (3 mm Hg) and b.p. 118-121°C (6 mm Hg).
Preparation of n-Caproic Anhydride

Flammability and Explosibility

Not classified

HEXANOIC ANHYDRIDE Preparation Products And Raw materials

Raw materials

Hexanoic acid ketene

Preparation Products

GERANYL CAPROATE N-OCTYL CAPROATE N-CAPROIC ACID ISOPROPYL ESTER Hexanamide PENTYL HEXANOATE

HEXANOIC ANHYDRIDE Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou KOYE Chemical Co.,LTD.	519-81882581 18602584369	Lydia@kwchem.com	China	114	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Beijing Donghualituo Techonlogy Development Co.,Ltd.	010-88425576	sales@dhltchem.com	China	793	59
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57

Supplier	Advantage
Changzhou KOYE Chemical Co.,LTD.	58
J & K SCIENTIFIC LTD.	76
Beijing Donghualituo Techonlogy Development Co.,Ltd.	59
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Adamas Reagent, Ltd.	59
Shandong Xiya Chemical Co., Ltd	57
Syntechem Co.,Ltd	57

View Lastest Price from HEXANOIC ANHYDRIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Hexanoic anhydride 2051-49-2	$1.00	1kg	99%	500000MT	Handan Huajun chemicals Co.,Ltd
2026-09-11	Hexanoic Anhydride 2051-49-2	$1.00	1kg	99.0%GC	500000MT	Handan Huajun chemicals Co.,Ltd
2026-06-30	HEXANOIC ANHYDRIDE 2051-49-2		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Hexanoic anhydride
2051-49-2
$1.00
99%
Handan Huajun chemicals Co.,Ltd

Hexanoic Anhydride
2051-49-2
$1.00
99.0%GC
Handan Huajun chemicals Co.,Ltd

HEXANOIC ANHYDRIDE
2051-49-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

HEXANOIC ANHYDRIDE Spectrum

HEXANOIC ANHYDRIDE(2051-49-2)MS HEXANOIC ANHYDRIDE(2051-49-2)¹HNMR HEXANOIC ANHYDRIDE(2051-49-2)¹³CNMR HEXANOIC ANHYDRIDE(2051-49-2)IR1 HEXANOIC ANHYDRIDE(2051-49-2)IR2 HEXANOIC ANHYDRIDE(2051-49-2)Raman

2051-49-2(HEXANOIC ANHYDRIDE)Related Search:

OCTANOPHENONE METHYL PROPYL SULFIDE 1-Mercaptooctane BEHENIC ANHYDRIDE N-CAPRYLIC ANHYDRIDE

2-ETHYLHEXANOIC ANHYDRIDE OLEIC ANHYDRIDE NONANOIC ANHYDRIDE LAURIC ANHYDRIDE HEPTANOIC ANHYDRIDE

STEARIC ANHYDRIDE RUBRATOXIN B HEXANOIC ANHYDRIDE MYRISTIC ANHYDRIDE DECANOIC ANHYDRIDE

Palmitic anhydride ELAIDIC ANHYDRIDE LINOLEIC ANHYDRIDE

1of4

N-BUTYLACETIC ANHYDRIDE N-CAPRONIC ANHYDRIDE N-CAPROIC ANHYDRIDE N-HEXANOIC ANHYDRIDE N-HEXOIC ANHYDRIDE PENTYLFORMIC ANHYDRIDE N-CAPROICANHYDRIDE=HEXANOICANHYDRIDE Bis(hexanoic)anhydride Biscaproic anhydride Bishexanoic anhydride Dihexanoic anhydride Hexanoic anhydride,97% Hexanoic anhydride, 97% 250GR Hexanoic anhydride, 97% 50GR Hexanoic acid,1,1'-anhydride Hexanoic anhydride 97% Caproic acid anhydride Capronic acid anhydride Capronic anhydride hexanoicacid,anhydride Hexanoicacidanhydride Hexanoyl anhydride n-Capriocanhydride n-Hexanoic acid anhydride HEXANOIC ANHYDRIDE 6-benzamido-2-bromohexanoic acid Hexanoic Anhydride > hexanoylhexanoate HEXANOIC ANHYDRIDE ISO 9001：2015 REACH High Quality HEXANOIC ANHYDRIDE CAS 2051-49-2 with Free sample CAPROIC ANHYDRIDE 2051-49-2 C12H22O3 CH3CH24CO2O C5H11CO2O Carboxylic Acid Anhydrides Carbonyl Compounds Building Blocks Organic Building Blocks Pharmaceutical Intermediates