Dimethyl malonate
- CAS No.
- 108-59-8
- Chemical Name:
- Dimethyl malonate
- Synonyms
- DMM;METHYL MALONATE;MALONIC ACID DIMETHYL ESTER;Dimethyl propanedioate;dimthyl malonate;DIMETHYL MALONAT;dimethyl1,3-propanedioate;MINA-009;Malonic acid d;Dimethyl malote
- CBNumber:
- CB3776436
- Molecular Formula:
- C5H8O4
- Molecular Weight:
- 132.11
- MDL Number:
- MFCD00008460
- MOL File:
- 108-59-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -62 °C (lit.) |
|---|---|
| Boiling point | 180-181 °C (lit.) |
| Density | 1.156 g/mL at 25 °C (lit.) |
| vapor density | >1 (vs air) |
| vapor pressure | 0.15 hPa (20 °C) |
| refractive index |
n |
| FLAVIS Number | 09.558 | Dimethyl malonate |
| Flash point | 194 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: miscible |
| pka | 11.80±0.46(Predicted) |
| form | Liquid |
| color | Clear colorless |
| Odor | fruity |
| explosive limit | 1.3-17.4%(V) |
| Water Solubility | negligible |
| Merck | 14,6096 |
| BRN | 774261 |
| Henry's Law Constant | 3.8×101 mol/(m3Pa) at 25℃, Katrib et al. (2003) |
| Dielectric constant | 10.4(20℃) |
| Stability | Stable. Incompatible with strong oxidizing agents. Flammable. |
| InChI | 1S/C5H8O4/c1-8-4(6)3-5(7)9-2/h3H2,1-2H3 |
| InChIKey | BEPAFCGSDWSTEL-UHFFFAOYSA-N |
| SMILES | COC(=O)CC(=O)OC |
| LogP | -0.05 at 20-25℃ and pH6.4 |
| CAS DataBase Reference | 108-59-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | EM8Y79998C |
| NIST Chemistry Reference | Propanedioic acid, dimethyl ester(108-59-8) |
| EPA Substance Registry System | Dimethyl malonate (108-59-8) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | NA1993 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | OO0950000 | |||||||||
| Autoignition Temperature | 440 °C | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | CBL | |||||||||
| HS Code | 29171910 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Toxicity | LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Excepted Quantities | Non-Hazardous | |||||||||
| NFPA 704 |
|
Dimethyl malonate price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 100mL | $38.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 500mL | $71 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 1L | $139 | 2026-04-30 | Buy |
| Sigma-Aldrich | 136441 | Dimethyl malonate 98% | 108-59-8 | 1kg | $128 | 2026-04-30 | Buy |
| TCI Chemical | M0030 | Dimethyl Malonate >98.0%(GC) | 108-59-8 | 25g | $32 | 2026-04-30 | Buy |
Dimethyl malonate Chemical Properties,Uses,Production
Description
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.
Chemical Properties
liquid
Chemical Properties
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.
Uses
It is used in fragrances and some artificial flavorings .
Uses
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.
Application
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
Production Methods
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.
General Description
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Hongjia Chemical Co., Ltd | 15253128188; 15253128188 | 315203407@qq.com | China | 69 | 58 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Weifang Weimeng Chemical Co., Ltd. | QQ 1340191485 15105445095 | weimengchem@163.com | China | 482 | 58 |
| Guangzhou Yuanda New Material Co., Ltd. | 19849939632; 19849939632 | 2470479589@qq.com | China | 4273 | 58 |
| Shandong fengpan New Material Co., Ltd | 18560028598 | 2584792069@qq.com | China | 77 | 58 |
| Nantong Ru Tong Chemical Co., Ltd | 18962933129 18962933129 | 1031672739@qq.com | China | 18 | 58 |
| Shanghai Yanze Chemical Co., Ltd | 19901447308 19962611955 | 260924549@qq.com | China | 2151 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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View Lastest Price from Dimethyl malonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | Dimethyl malonate
108-59-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Dimethyl malonate
108-59-8
|
1KG | 99.5% | 1000mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2026-09-02 | Dimethyl malonate
108-59-8
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- Dimethyl malonate
108-59-8
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Dimethyl malonate
108-59-8
- $0.00
- 99.5%
- Jinan Finer Chemical Co., Ltd
-
- Dimethyl malonate
108-59-8
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
108-59-8(Dimethyl malonate)Related Search:
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