H-Cys-4-abz-Met-OH
- CAS No.
- 156707-43-6
- Chemical Name:
- H-Cys-4-abz-Met-OH
- Synonyms
- FTI II;FTASE INHIBITOR II;H-Cys-4-abz-Met-OH;FTase Inhibitor II（TFA salt）;CYSTEINE-(4-AMINOBENOZYL)METHIONINE;N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine;L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]-;(2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid
- CBNumber:
- CB3777453
- Molecular Formula:
- C15H21N3O4S2
- Molecular Weight:
- 371.48
- MDL Number:
- MFCD00798742
- MOL File:
- 156707-43-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
H-Cys-4-abz-Met-OH price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16607 | FTase Inhibitor II ≥80% | 156707-43-6 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16607 | FTase Inhibitor II ≥80% | 156707-43-6 | 5mg | $168 | 2024-03-01 | Buy |
| Biosynth | FC109033 | H-Cys-4-Abz-Met-OH | 156707-43-6 | 10mg | $900 | 2026-06-04 | Buy |
| Biosynth | FC109033 | H-Cys-4-Abz-Met-OH | 156707-43-6 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FC109033 | H-Cys-4-Abz-Met-OH | 156707-43-6 | 25mg | $1030.75 | 2026-06-04 | Buy |
H-Cys-4-abz-Met-OH Chemical Properties, Uses, Production
Uses
FTase Inhibitor II acts as a cell permeable analog of farnesyl pyrophosphate (FPP) that potently inhibits FTase. Possible cancer therapeutic agent
Biological Activity
ftase inhibitor ii is a potent farnesyl transferase inhibitor.protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.
in vitro
previous study found that cells were treated with ftase inhibitor ii and two ggtase inhibitors (ggti-286 and ggti-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μm of the drugs were added to the culture. in addition, when cells were treated with a combination of ggti-2147 and ftase inhibitor ii, ranging from 0.1 nm to 100 μm, cell growth was not affected. additionally, in the presence of both 50 μm ftase inhibitor ii and 50 μm ggti-2147, the ftase and ggtase i enzyme activities were abolished [1].
References
[1] v. manne, c. s. ricca, j. g. brown, et al. ras farnesylation as a target for novel antitumor agents: potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. drug development research 34, 121-137 (1995).
H-Cys-4-abz-Met-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-Cys-4-abz-Met-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4726 | 58 |
| Nanjing NingFan Pharm-Tech CO. LTD. | 17368696818 | China | 1976 | 58 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
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