Azaconazole
- CAS No.
- 60207-31-0
- Chemical Name:
- Azaconazole
- Synonyms
- RODEWOD;madurox;R-28644;Aids108350;azoconozole;SAFETRAY SL;AZACONAZOLE;AZOCONAZOLE;Aids-108350;Azaconazol, Vetranal
- CBNumber:
- CB3780871
- Molecular Formula:
- C12H11Cl2N3O2
- Molecular Weight:
- 300.14
- MDL Number:
- MFCD00865600
- MOL File:
- 60207-31-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 109.9° |
|---|---|
| Boiling point | 460.7±55.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| vapor pressure | 8.6 x l0-6 Pa (20 °C) |
| storage temp. | 0-6°C |
| Water Solubility | 300 mg l-1 (20 °C) |
| pka | 2.94±0.12(Predicted) |
| Henry's Law Constant | 5.1×104 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Major Application |
agriculture environmental |
| InChI | 1S/C12H11Cl2N3O2/c13-9-1-2-10(11(14)5-9)12(18-3-4-19-12)6-17-8-15-7-16-17/h1-2,5,7-8H,3-4,6H2 |
| InChIKey | AKNQMEBLVAMSNZ-UHFFFAOYSA-N |
| SMILES | Clc1ccc(c(Cl)c1)C3(Cn2cncn2)OCCO3 |
| CAS DataBase Reference | 60207-31-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 45683D94EU |
| EPA Substance Registry System | Azaconazole (60207-31-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 46 |
| WGK Germany | 1 |
| RTECS | XZ4605000 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Azaconazole price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CRM34045 | Azaconazole certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 60207-31-0 | 50 mg | $64.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 34045 | Azaconazole PESTANAL?, analytical standard | 60207-31-0 | 100mg | $73.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | CRM34045 | Azaconazole certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 60207-31-0 | 1 unit | $60.1 | 2025-07-31 | Buy |
| Biosynth | KCA20731 | Azaconazole | 60207-31-0 | 1000mg | $1010 | 2026-06-04 | Buy |
| Crysdot | CD30000019 | 1-((2-(2,4-Dichlorophenyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole 95+% | 60207-31-0 | 1g | $772 | 2026-05-27 | Buy |
Azaconazole Chemical Properties,Uses,Production
Description
Azaconazole is a sterol biosynthesis inhibitor with fungicidal action. It is moderately soluble in water, relatively volatile and may be persistent in aquatic systems. Azaconazole is moderately toxic to mammals but is not expected to bioaccumulate. It is moderately toxic to birds, fish and aquatic invertebrates.
Originator
Azaconazole,Chemical
Uses
Fungicide for cultivation on wood; preservative for composite wood products.
Uses
Azaconazole is particularly active against wood-destroying and sapstain fungi. It is also used as a disinfectant in mushroom cultivation and on storage boxes for fruit and vegetables.
Definition
ChEBI: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2,4-dichlorophenyl and 1,2,4-triazol-1-ylmethyl groups. A fungicide used mainly in ornamental crops to control canker and other diseases. Azaconazole is moderately toxic to mammals but is not expected to bioaccumulate. It is moderately toxic to birds, fish and aquatic invertebrates.
Production Methods
Azaconazole is synthesised through a multi-step process involving the alkylation of 4-amino-4H-1,2,4-triazole. The production begins with the preparation of key intermediates, notably 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone. This compound is formed by reacting 2,4-dichlorophenyl precursors with triazole derivatives under controlled conditions. The final step involves coupling this intermediate with additional reagents to yield azaconazole.
Manufacturing Process
A stirred and cooled (0°C) solution of 1-(2,4-diaminophenyl)-1-ethanone in a
concentrated hydrochloric acid solution, water and acetic acid was diazotated
with a solution of sodium nitrite in water. After stirring at 0°C, the whole was
poured onto a solution of copper (I) chloride in a concentrated hydrochloric
acid solution while stirring. The mixture was heated at 60°C. After cooling to
room temperature, the product was extracted twice with 2,2'-oxybispropane.
The combined extracts were washed successively with water, a diluted sodium
hydroxide solution and again twice with water, dried, filtered and evaporated,
yielding 1-(2,4-dichlorophenyl)-1-ethanone.
1-(2,4-Dichlorophenyl)-1-ethanon were dissolved in 1,2-ethanediol at heating.
While stirring bromine were added dropwise, without external heating. After
stirring at room temperature, 4-methylbenzenesulfonic acid and benzene were
added. The whole was stirred and refluxed overnight with water-separator.
The reaction mixture was evaporated and the residue was taken up in 2,2'-
oxybispropane. The resulting solution was washed successively once with a
dilute sodium hydroxide solution and 3 times with water, dried, filtered and
evaporated. The residue was distilled, yielding 2-(bromomethyl)-2-(2,4-
dichlorophenyl)-1,3-dioxolane.
6.9 parts of 1H-1,2,4-triazole in 150 parts of dimethylformamide were added
to a stirred solution of 2.3 parts of sodium in 120 parts of methanol. The
methanol was removed at normal pressure until the internal temperature of
130°C was reached. Then, 25 parts of 2-(bromomethyl)-2-(2,4-
dichlorophenyl)-1,3-dioxolane were added. The reaction-mixture was stirred
and refluxed for 3 h. It was allowed to cool to room temperature and poured
onto water. The precipitated product was filtered off, yielding 12 parts of 1-[2-
(2,4-dichlorophenyl)-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole, melting
point 109.9°C (crystallized from diisopropylether, activated charcoal).
Therapeutic Function
Antifungal
Mechanism of action
Sterol biosynthesis inhibitor
Metabolic pathway
Little published dormation is available on the metabolism of azaconazole.
Degradation
Azaconazole is stable to light under normal storage conditions (but not in ketonic solvents). It is stable at temperatures up to 220 °C.
Pesticide Type
Fungicide
Azaconazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| TianJin Alta Scientific Co., Ltd. | 022-65378550-8551 | contact@altascientific.com | China | 2772 | 58 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| Nanjing Abix Biochemical Technology Co., Ltd. | 025-87193546 18652950785; | chemweiao@163.com | China | 9009 | 60 |
| Shanghai Xilong Biochemical Technology Co., Ltd. | 021-52907766-8042 | China | 9928 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
View Lastest Price from Azaconazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-19 | Azaconazole
60207-31-0
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- Azaconazole
60207-31-0
- $3.00
- 98%
- Career Henan Chemical Co
