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ChemicalBook >> CAS DataBase List >>2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Structure
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- structure
CAS No.
326823-27-2
Chemical Name:
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-
Synonyms
PNU292137;PNU-292137;PNU 292137;2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-
CBNumber:
CB38366194
Molecular Formula:
C18H17N3O
Molecular Weight:
291.35
MDL Number:
MOL File:
326823-27-2.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Properties

Boiling point 621.7±50.0 °C(Predicted)
Density 1.343±0.06 g/cm3(Predicted)
pka 13.44±0.10(Predicted)
FDA UNII 64H5U84UFB

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0080966 PNU-292137 99.95% 326823-27-2 5mg $287 2026-06-04 Buy
ChemScene CS-0080966 PNU-292137 99.95% 326823-27-2 10mg $460 2026-06-04 Buy
ChemScene CS-0080966 PNU-292137 99.95% 326823-27-2 25mg $877 2026-06-04 Buy
ChemScene CS-0080966 PNU-292137 99.95% 326823-27-2 50mg $1360 2026-06-04 Buy
ChemScene CS-0080966 PNU-292137 99.95% 326823-27-2 100mg $2112 2026-06-04 Buy
Product number Packaging Price Buy
CS-0080966 5mg $287 Buy
CS-0080966 10mg $460 Buy
CS-0080966 25mg $877 Buy
CS-0080966 50mg $1360 Buy
CS-0080966 100mg $2112 Buy

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Chemical Properties, Uses, Production

Uses

PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model[1].

IC 50

CDK2/cyclinA: 37 nM (IC50); CDK2/cyclin E: 92 nM (IC50); Cdk5/p25: 114 nM (IC50); CDK1/cyclinB: 270 nM (IC50); CDK4/cyclinD1: >10000 nM (IC50); GSK-3β: 1905 nM (IC50); ERK-2: 4600 nM (IC50)

References

[1] Paolo Pevarello, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 2004 Jun 17;47(13):3367-80. DOI:10.1021/jm031145u

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9780 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PNU-292137 pictures 2026-05-11 PNU-292137
326823-27-2
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • PNU-292137 pictures
  • PNU-292137
    326823-27-2
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

326823-27-2 (2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-) Related Search:

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GSK-3326595

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2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- PNU 292137 PNU292137 PNU-292137 326823-27-2